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• W1826718054 abstract "The present study investigated the route and degree of uptake of 2 ionizable pharmaceuticals (diclofenac and fluoxetine) and 1 ionizable compound used in personal care products (triclosan) into the sediment-dwelling worm Lumbriculus variegatus. Studies were done on complete worms (“feeding”) and worms where the head was absent (“nonfeeding”) using 14C-labeled ingredients. Biota sediment accumulation factors (BSAF), based on uptake of 14C, for feeding worms increased in the order fluoxetine (0.3) < diclofenac (0.5) < triclosan (9), which is correlated with a corresponding increase in log octanol–water partition coefficient. Biota sediment accumulation factor estimates are representative of maximum values because the degree of biotransformation in the worms was not quantified. Although no significant differences were seen between the uptake of diclofenac and that of fluoxetine in feeding and nonfeeding worms, uptake of the more hydrophobic antimicrobial, triclosan, into the feeding worms was significantly greater than that in the nonfeeding worms, with the 48-h BSAF for feeding worms being 36% higher than that for the nonfeeding worms. The results imply that dietary uptake contributes to the uptake of triclosan, which may be a result of the high hydrophobicity of the compound. Models that estimate exposure of ionizable substances may need to consider uptake from both the water column and food, particularly when assessing risks from dynamic exposures to organic contaminants. Environ Toxicol Chem 2016;35:836–842. © 2015 SETAC" @default.
• W1826718054 created "2016-06-24" @default.
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• W1826718054 date "2015-07-02" @default.
• W1826718054 modified "2023-09-30" @default.
• W1826718054 title "Routes of uptake of diclofenac, fluoxetine, and triclosan into sediment-dwelling worms" @default.
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• W1826718054 doi "https://doi.org/10.1002/etc.3020" @default.
• W1826718054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25892588" @default.
• W1826718054 hasPublicationYear "2015" @default.
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