Matches in SemOpenAlex for { <https://semopenalex.org/work/W1826939892> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1826939892 endingPage "G744" @default.
- W1826939892 startingPage "G737" @default.
- W1826939892 abstract "The functional significance of the presence of opioid peptides in enzymatic digestion of food proteins remains uncertain. The effect of natural beta-casomorphins (beta-CMs), beta-CM-5 and beta-CM-4-NH2 (morphiceptine), and the analogue beta-[D-Ala2,4,Tyr5]CM-5-NH2 were studied in isolated rabbit ileum mounted in Ussing chambers. All three peptides caused a naloxone-reversible reduction in short-circuit current (Isc) after addition at a concentration of 10(-4) M to the serosal side of the tissue. After addition to the mucosal side, only the analogue beta-[D-Ala2,4,Tyr5]CM-5-NH2 reduced Isc. Natural beta-CMs were degraded by the intestinal mucosa, and no intact transepithelial passage was detected for these peptides, whereas beta-[D-Ala2,4,Tyr5]CM-5-NH2 was demonstrated to cross the epithelium intact when added at a concentration of 10(-3) M in the mucosal reservoir (mucosal-to-serosal flux = 3.5 +/- 1.2 nmol.h-1.cm-2). These results show that both natural beta-CMs and the protected analogue have an opiate activity on intestinal electrolyte transport. Their action from the luminal side of the intestine seems to depend on the transfer of the intact peptides from the luminal to the blood side of the tissue where opiate receptors are located. This action is prevented by luminal hydrolysis of the natural peptides." @default.
- W1826939892 created "2016-06-24" @default.
- W1826939892 creator A5009679710 @default.
- W1826939892 creator A5011388504 @default.
- W1826939892 creator A5015731288 @default.
- W1826939892 creator A5087738489 @default.
- W1826939892 date "1987-12-01" @default.
- W1826939892 modified "2023-10-17" @default.
- W1826939892 title "Opiate activity and transepithelial passage of intact beta-casomorphins in rabbit ileum" @default.
- W1826939892 doi "https://doi.org/10.1152/ajpgi.1987.253.6.g737" @default.
- W1826939892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3425715" @default.
- W1826939892 hasPublicationYear "1987" @default.
- W1826939892 type Work @default.
- W1826939892 sameAs 1826939892 @default.
- W1826939892 citedByCount "22" @default.
- W1826939892 countsByYear W18269398922012 @default.
- W1826939892 countsByYear W18269398922020 @default.
- W1826939892 countsByYear W18269398922021 @default.
- W1826939892 crossrefType "journal-article" @default.
- W1826939892 hasAuthorship W1826939892A5009679710 @default.
- W1826939892 hasAuthorship W1826939892A5011388504 @default.
- W1826939892 hasAuthorship W1826939892A5015731288 @default.
- W1826939892 hasAuthorship W1826939892A5087738489 @default.
- W1826939892 hasConcept C126322002 @default.
- W1826939892 hasConcept C134018914 @default.
- W1826939892 hasConcept C170493617 @default.
- W1826939892 hasConcept C185592680 @default.
- W1826939892 hasConcept C199360897 @default.
- W1826939892 hasConcept C202751555 @default.
- W1826939892 hasConcept C2776174256 @default.
- W1826939892 hasConcept C2777226302 @default.
- W1826939892 hasConcept C2777803847 @default.
- W1826939892 hasConcept C2778140631 @default.
- W1826939892 hasConcept C2778750930 @default.
- W1826939892 hasConcept C2779932011 @default.
- W1826939892 hasConcept C2781063702 @default.
- W1826939892 hasConcept C41008148 @default.
- W1826939892 hasConcept C55493867 @default.
- W1826939892 hasConcept C71924100 @default.
- W1826939892 hasConcept C86803240 @default.
- W1826939892 hasConcept C88016717 @default.
- W1826939892 hasConcept C98274493 @default.
- W1826939892 hasConceptScore W1826939892C126322002 @default.
- W1826939892 hasConceptScore W1826939892C134018914 @default.
- W1826939892 hasConceptScore W1826939892C170493617 @default.
- W1826939892 hasConceptScore W1826939892C185592680 @default.
- W1826939892 hasConceptScore W1826939892C199360897 @default.
- W1826939892 hasConceptScore W1826939892C202751555 @default.
- W1826939892 hasConceptScore W1826939892C2776174256 @default.
- W1826939892 hasConceptScore W1826939892C2777226302 @default.
- W1826939892 hasConceptScore W1826939892C2777803847 @default.
- W1826939892 hasConceptScore W1826939892C2778140631 @default.
- W1826939892 hasConceptScore W1826939892C2778750930 @default.
- W1826939892 hasConceptScore W1826939892C2779932011 @default.
- W1826939892 hasConceptScore W1826939892C2781063702 @default.
- W1826939892 hasConceptScore W1826939892C41008148 @default.
- W1826939892 hasConceptScore W1826939892C55493867 @default.
- W1826939892 hasConceptScore W1826939892C71924100 @default.
- W1826939892 hasConceptScore W1826939892C86803240 @default.
- W1826939892 hasConceptScore W1826939892C88016717 @default.
- W1826939892 hasConceptScore W1826939892C98274493 @default.
- W1826939892 hasIssue "6" @default.
- W1826939892 hasLocation W18269398921 @default.
- W1826939892 hasLocation W18269398922 @default.
- W1826939892 hasOpenAccess W1826939892 @default.
- W1826939892 hasPrimaryLocation W18269398921 @default.
- W1826939892 hasRelatedWork W1873301473 @default.
- W1826939892 hasRelatedWork W1996287736 @default.
- W1826939892 hasRelatedWork W2021860689 @default.
- W1826939892 hasRelatedWork W2025620937 @default.
- W1826939892 hasRelatedWork W2039496949 @default.
- W1826939892 hasRelatedWork W2040166858 @default.
- W1826939892 hasRelatedWork W2048277806 @default.
- W1826939892 hasRelatedWork W2061034372 @default.
- W1826939892 hasRelatedWork W2072002913 @default.
- W1826939892 hasRelatedWork W2410789196 @default.
- W1826939892 hasVolume "253" @default.
- W1826939892 isParatext "false" @default.
- W1826939892 isRetracted "false" @default.
- W1826939892 magId "1826939892" @default.
- W1826939892 workType "article" @default.