FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1827006191> ?p ?o ?g. }

• W1827006191 endingPage "2773" @default.
• W1827006191 startingPage "2762" @default.
• W1827006191 abstract "Lactation is associated with increased bone turnover and rapid bone loss, which liberates skeletal calcium used for milk production. Previous studies suggested that an increase in the skeletal expression of receptor activator of nuclear factor kappa-light-chain-enhancer of activated B cells ligand (RANKL) coupled with a decrease in osteoprotegerin (OPG) levels likely triggered bone loss during lactation. In this study, we treated lactating mice with recombinant OPG to determine whether bone loss during lactation was dependent on RANKL signaling and whether resorption of the maternal skeleton was required to support milk production. OPG treatment lowered bone resorption rates and completely prevented bone loss during lactation but, surprisingly, did not decrease osteoclast numbers. In contrast, OPG was quite effective at lowering osteoblast numbers and inhibiting bone formation in lactating mice. Furthermore, treatment with OPG during lactation prevented the usual anabolic response associated with reversal of lactational bone loss after weaning. Preventing bone loss had no appreciable effect on milk production, milk calcium levels, or maternal calcium homeostasis when mice were on a standard diet. However, when dietary calcium was restricted, treatment with OPG caused maternal hypocalcemia, maternal death, and decreased milk production. These studies demonstrate that RANKL signaling is a requirement for bone loss during lactation, and suggest that osteoclast activity may be required to increase osteoblast numbers during lactation in preparation for the recovery of bone mass after weaning. These data also demonstrate that maternal bone loss is not absolutely required to supply calcium for milk production unless dietary calcium intake is inadequate." @default.
• W1827006191 created "2016-06-24" @default.
• W1827006191 creator A5019819711 @default.
• W1827006191 creator A5027842732 @default.
• W1827006191 creator A5056376224 @default.
• W1827006191 creator A5059432876 @default.
• W1827006191 creator A5062356491 @default.
• W1827006191 creator A5069142714 @default.
• W1827006191 creator A5070258179 @default.
• W1827006191 creator A5080866022 @default.
• W1827006191 date "2015-08-01" @default.
• W1827006191 modified "2023-10-13" @default.
• W1827006191 title "OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism" @default.
• W1827006191 cites W1485574354 @default.
• W1827006191 cites W1594128336 @default.
• W1827006191 cites W1963957178 @default.
• W1827006191 cites W1964264171 @default.
• W1827006191 cites W1964361842 @default.
• W1827006191 cites W1968799724 @default.
• W1827006191 cites W1974305386 @default.
• W1827006191 cites W1977409318 @default.
• W1827006191 cites W1979678145 @default.
• W1827006191 cites W1982063012 @default.
• W1827006191 cites W1985449982 @default.
• W1827006191 cites W1988188057 @default.
• W1827006191 cites W1995181362 @default.
• W1827006191 cites W1997880790 @default.
• W1827006191 cites W2000067978 @default.
• W1827006191 cites W2000647744 @default.
• W1827006191 cites W2004496677 @default.
• W1827006191 cites W2013908114 @default.
• W1827006191 cites W2035416199 @default.
• W1827006191 cites W2036279558 @default.
• W1827006191 cites W2037489361 @default.
• W1827006191 cites W2039712973 @default.
• W1827006191 cites W2041255757 @default.
• W1827006191 cites W2043485699 @default.
• W1827006191 cites W2048299560 @default.
• W1827006191 cites W2049467531 @default.
• W1827006191 cites W2050854526 @default.
• W1827006191 cites W2050870573 @default.
• W1827006191 cites W2051320963 @default.
• W1827006191 cites W2057649851 @default.
• W1827006191 cites W2070430161 @default.
• W1827006191 cites W2072253784 @default.
• W1827006191 cites W2072471551 @default.
• W1827006191 cites W2073303754 @default.
• W1827006191 cites W2078628715 @default.
• W1827006191 cites W2079993792 @default.
• W1827006191 cites W2085922591 @default.
• W1827006191 cites W2088025468 @default.
• W1827006191 cites W2112901782 @default.
• W1827006191 cites W2122145257 @default.
• W1827006191 cites W2126004400 @default.
• W1827006191 cites W2126989082 @default.
• W1827006191 cites W2129533800 @default.
• W1827006191 cites W2133227855 @default.
• W1827006191 cites W2133551420 @default.
• W1827006191 cites W2137510224 @default.
• W1827006191 cites W2139996507 @default.
• W1827006191 cites W2143252903 @default.
• W1827006191 cites W2144591040 @default.
• W1827006191 cites W2149936178 @default.
• W1827006191 doi "https://doi.org/10.1210/en.2015-1232" @default.
• W1827006191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4511126" @default.
• W1827006191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25961842" @default.
• W1827006191 hasPublicationYear "2015" @default.
• W1827006191 type Work @default.
• W1827006191 sameAs 1827006191 @default.
• W1827006191 citedByCount "24" @default.
• W1827006191 countsByYear W18270061912016 @default.
• W1827006191 countsByYear W18270061912017 @default.
• W1827006191 countsByYear W18270061912018 @default.
• W1827006191 countsByYear W18270061912019 @default.
• W1827006191 countsByYear W18270061912020 @default.
• W1827006191 countsByYear W18270061912021 @default.
• W1827006191 countsByYear W18270061912022 @default.
• W1827006191 countsByYear W18270061912023 @default.
• W1827006191 crossrefType "journal-article" @default.
• W1827006191 hasAuthorship W1827006191A5019819711 @default.
• W1827006191 hasAuthorship W1827006191A5027842732 @default.
• W1827006191 hasAuthorship W1827006191A5056376224 @default.
• W1827006191 hasAuthorship W1827006191A5059432876 @default.
• W1827006191 hasAuthorship W1827006191A5062356491 @default.
• W1827006191 hasAuthorship W1827006191A5069142714 @default.
• W1827006191 hasAuthorship W1827006191A5070258179 @default.
• W1827006191 hasAuthorship W1827006191A5080866022 @default.
• W1827006191 hasBestOaLocation W18270061911 @default.
• W1827006191 hasConcept C126322002 @default.
• W1827006191 hasConcept C134018914 @default.
• W1827006191 hasConcept C170033053 @default.
• W1827006191 hasConcept C170493617 @default.
• W1827006191 hasConcept C185592680 @default.
• W1827006191 hasConcept C202751555 @default.
• W1827006191 hasConcept C2776033226 @default.
• W1827006191 hasConcept C2776541429 @default.
• W1827006191 hasConcept C2776659692 @default.
• W1827006191 hasConcept C2776886416 @default.

• next