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• W1827173896 endingPage "472" @default.
• W1827173896 startingPage "472" @default.
• W1827173896 abstract "The goal of this study was to examine the effect of Sargassum coreanum extract (SCE) on blood glucose concentration and insulin resistance in C57BL-KsJ-db/db mice.For 6 weeks, male C57BL/KsJ-db/db mice were administrated SCE (0.5%, w/w), and rosiglitazone (0.005%, w/w).A supplement of the SCE for 6 weeks induced a significant reduction in blood glucose and glycosylated hemoglobin concentrations, and it improved hyperinsulinemia compared to the diabetic control db/db mice. The glucokinase activity in the hepatic glucose metabolism increased in the SCE-supplemented db/db mice, while phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities in the SCE-supplemented db/db mice were significantly lower than those in the diabetic control db/db mice. The homeostatic index of insulin resistance was lower in the SCE-supplemented db/db mice than in the diabetic control db/db mice.These results suggest that a supplement of the SCE lowers the blood glucose concentration by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance." @default.
• W1827173896 created "2016-06-24" @default.
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• W1827173896 date "2015-01-01" @default.
• W1827173896 modified "2023-09-26" @default.
• W1827173896 title "<i>Sargassum coreanum</i>extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice" @default.
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• W1827173896 doi "https://doi.org/10.4162/nrp.2015.9.5.472" @default.
• W1827173896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4575959" @default.
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