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• W1827508716 abstract "Recurrent pathogenic mutations in IDH1 and IDH2 at the conserved amino acid sites IDH1-R132, IDH2-R140 and IDH2-R172 occur in ~20% of patients with acute myeloid leukemia (AML).1 A recent analysis of AML patients at our institution identified IDH1/2 mutations in 20% (n=167) of 826 AML patients, with IDH1/2 mutations occurring most frequently in the setting of diploid karyotype or other intermediate-risk cytogenetics, particularly trisomy 8 (77 vs 53%, P<0.0005). AML patients with IDH1/2 mutations were overall less likely to have a diagnosis of therapy-related AML (8 vs 17%, P=0.003).2" @default.
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• W1827508716 date "2015-07-31" @default.
• W1827508716 modified "2023-10-15" @default.
• W1827508716 title "IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression" @default.
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• W1827508716 doi "https://doi.org/10.1038/leu.2015.211" @default.
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