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- W1827734958 abstract "Publisher Summary This chapter provides an introduction and ecological aspects, pharmacological effects of polyamine toxins in invertebrates, pharmacological effects of polyamine toxins in vertebrates, structure-activity relationship studies, and perspectives of polyamine toxins from spiders and wasps. Spiders, which normally prey exclusively on insects, are considered among the dominant predators of most terrestrial ecosystems. Venom constituents can be divided simply into proteins and nonproteins. The proteinaceous toxins range in size from a few thousand to several thousand kilodaltons. The venom of more highly evolved spiders, notably the orb-weaving spiders in the family Araneidae, contains low-molecular-weight polyamine toxins. Polyamine toxins from spiders and wasps are potent antagonists of receptors for the excitatory amino acid (EAA) glutamate in invertebrates and vertebrates. As such, polyamine toxins represent new chemical leads for the development of insecticide and human therapeutic products, for example, N-methyl-D-aspartate receptors have been implicated in a variety of CNS disorders, including epilepsy, ischemic cell death, neurodegeneration, analgesia, and anxiety." @default.
- W1827734958 created "2016-06-24" @default.
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- W1827734958 date "1995-01-01" @default.
- W1827734958 modified "2023-09-27" @default.
- W1827734958 title "Chapter 2 Pharmacology of Polyamine Toxins from Spiders and Wasps" @default.
- W1827734958 cites W11230068 @default.
- W1827734958 cites W1557004700 @default.
- W1827734958 cites W1660861487 @default.
- W1827734958 cites W1964030958 @default.
- W1827734958 cites W1966553679 @default.
- W1827734958 cites W1969730354 @default.
- W1827734958 cites W1971671517 @default.
- W1827734958 cites W1972183007 @default.
- W1827734958 cites W1973949367 @default.
- W1827734958 cites W1977702888 @default.
- W1827734958 cites W1978247734 @default.
- W1827734958 cites W1979647308 @default.
- W1827734958 cites W1980360827 @default.
- W1827734958 cites W1985965709 @default.
- W1827734958 cites W1987460091 @default.
- W1827734958 cites W1990744618 @default.
- W1827734958 cites W1993903576 @default.
- W1827734958 cites W1994839817 @default.
- W1827734958 cites W1997559402 @default.
- W1827734958 cites W2001566678 @default.
- W1827734958 cites W2005807247 @default.
- W1827734958 cites W2012586761 @default.
- W1827734958 cites W2018154074 @default.
- W1827734958 cites W2018615582 @default.
- W1827734958 cites W2019059770 @default.
- W1827734958 cites W2020137064 @default.
- W1827734958 cites W2021565687 @default.
- W1827734958 cites W2025025590 @default.
- W1827734958 cites W2029508498 @default.
- W1827734958 cites W2032440072 @default.
- W1827734958 cites W2033250487 @default.
- W1827734958 cites W2035479527 @default.
- W1827734958 cites W2037423018 @default.
- W1827734958 cites W2038343233 @default.
- W1827734958 cites W2039364163 @default.
- W1827734958 cites W2039592913 @default.
- W1827734958 cites W2046029023 @default.
- W1827734958 cites W2047730283 @default.
- W1827734958 cites W2049321118 @default.
- W1827734958 cites W2049511526 @default.
- W1827734958 cites W2051950544 @default.
- W1827734958 cites W2052018605 @default.
- W1827734958 cites W2054461985 @default.
- W1827734958 cites W2054896141 @default.
- W1827734958 cites W2059600758 @default.
- W1827734958 cites W2061932481 @default.
- W1827734958 cites W2067917297 @default.
- W1827734958 cites W2076331416 @default.
- W1827734958 cites W2076657950 @default.
- W1827734958 cites W2077120617 @default.
- W1827734958 cites W2077776190 @default.
- W1827734958 cites W2078204790 @default.
- W1827734958 cites W2078771258 @default.
- W1827734958 cites W2081799398 @default.
- W1827734958 cites W2082371076 @default.
- W1827734958 cites W2083647519 @default.
- W1827734958 cites W2083879788 @default.
- W1827734958 cites W2084029736 @default.
- W1827734958 cites W2086900577 @default.
- W1827734958 cites W2089153445 @default.
- W1827734958 cites W2090247833 @default.
- W1827734958 cites W2092860293 @default.
- W1827734958 cites W2094885571 @default.
- W1827734958 cites W2095358033 @default.
- W1827734958 cites W2098449047 @default.
- W1827734958 cites W2111324043 @default.
- W1827734958 cites W2131980720 @default.
- W1827734958 cites W2132115645 @default.
- W1827734958 cites W2141660740 @default.
- W1827734958 cites W2146881390 @default.
- W1827734958 cites W2157410636 @default.
- W1827734958 cites W2157449230 @default.
- W1827734958 cites W2164359216 @default.
- W1827734958 cites W2181020825 @default.
- W1827734958 cites W2197878426 @default.
- W1827734958 cites W2308715930 @default.
- W1827734958 cites W2335199455 @default.
- W1827734958 cites W2470334616 @default.
- W1827734958 cites W2767552274 @default.
- W1827734958 cites W2951418192 @default.
- W1827734958 cites W319665486 @default.
- W1827734958 cites W4300883403 @default.
- W1827734958 cites W2069443138 @default.
- W1827734958 cites W985525309 @default.
- W1827734958 doi "https://doi.org/10.1016/s0099-9598(08)60286-2" @default.
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