FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1827800528> ?p ?o ?g. }

• W1827800528 endingPage "425" @default.
• W1827800528 startingPage "415" @default.
• W1827800528 abstract "A systematic search for mutations affecting the retinotectal projection in zebrafish larvae was performed, as part of the large-scale Tubingen screen for homozygous diploid mutants in embryonic development. 2,746 inbred lines (F2 families) from males mutagenized with ethylnitroso urea were screened. In wild-type larvae, developing retinal axons travel along a stereotyped route to the contralateral optic tectum. Here, their terminals form a highly ordered retinotopic map. To detect deviations from this pattern, an axon tracing assay was developed that permits screening of large numbers of mutagenized fish. Two fluorescent tracer dyes (DiI and DiO) were injected at opposite poles of the eyes of day-5 aldehyde-fixed larvae. 12 hours later, retinal axons were labelled over their entire length, and could be observed through the intact skin. The assay procedure (aldehyde fixation, mounting, injection of dyes, microscopic analysis) took about 1 minute per fish. In total, 125,000 individual fish larvae were processed. During the screen, 114 mutations in approx. 35 genes were discovered. For the mutants subjected to complementation testing, the number of alleles per locus ranges from 1 to 15. The mutations affect distinct steps in the retinotectal pathway, from pathfinding between eye and tectum to map formation along the dorsal-ventral and the anterior-posterior axis of the tectum. Mutations that disturb axon pathfinding to the tectum for the most part do not disrupt retinotopic mapping, and vice versa. The majority of the mutants display associated defects in other tissues and die before day 10. These mutants provide new tools for studying the formation of neuronal maps. The results of this screen show that a large-scale genetic approach can be applied to relatively late and circumscribed developmental processes in the vertebrate brain." @default.
• W1827800528 created "2016-06-24" @default.
• W1827800528 creator A5012853684 @default.
• W1827800528 creator A5046141141 @default.
• W1827800528 creator A5051307830 @default.
• W1827800528 creator A5067248001 @default.
• W1827800528 creator A5069574773 @default.
• W1827800528 creator A5072765144 @default.
• W1827800528 date "1996-12-01" @default.
• W1827800528 modified "2023-10-14" @default.
• W1827800528 title "Genetic dissection of the retinotectal projection" @default.
• W1827800528 cites W1008603429 @default.
• W1827800528 cites W1491742607 @default.
• W1827800528 cites W1534550058 @default.
• W1827800528 cites W1541802623 @default.
• W1827800528 cites W172845629 @default.
• W1827800528 cites W1751159137 @default.
• W1827800528 cites W1827800528 @default.
• W1827800528 cites W1854866862 @default.
• W1827800528 cites W1859795936 @default.
• W1827800528 cites W1862715713 @default.
• W1827800528 cites W1862773335 @default.
• W1827800528 cites W1883029646 @default.
• W1827800528 cites W1887547583 @default.
• W1827800528 cites W1913092726 @default.
• W1827800528 cites W1947859348 @default.
• W1827800528 cites W1966855385 @default.
• W1827800528 cites W1977455576 @default.
• W1827800528 cites W1980094138 @default.
• W1827800528 cites W1990195067 @default.
• W1827800528 cites W1994713664 @default.
• W1827800528 cites W1998354909 @default.
• W1827800528 cites W1999751317 @default.
• W1827800528 cites W2000572318 @default.
• W1827800528 cites W2008506955 @default.
• W1827800528 cites W2009949333 @default.
• W1827800528 cites W2017567461 @default.
• W1827800528 cites W2018425216 @default.
• W1827800528 cites W2019357185 @default.
• W1827800528 cites W2026842644 @default.
• W1827800528 cites W2034577585 @default.
• W1827800528 cites W2038516092 @default.
• W1827800528 cites W2041700814 @default.
• W1827800528 cites W2043287884 @default.
• W1827800528 cites W2046837764 @default.
• W1827800528 cites W2046968637 @default.
• W1827800528 cites W2054244592 @default.
• W1827800528 cites W2054519508 @default.
• W1827800528 cites W2058047705 @default.
• W1827800528 cites W2060015752 @default.
• W1827800528 cites W2071877947 @default.
• W1827800528 cites W2077525498 @default.
• W1827800528 cites W2085287004 @default.
• W1827800528 cites W2095048477 @default.
• W1827800528 cites W2123938765 @default.
• W1827800528 cites W2125430316 @default.
• W1827800528 cites W2129076056 @default.
• W1827800528 cites W2131173110 @default.
• W1827800528 cites W2160103054 @default.
• W1827800528 cites W2162502007 @default.
• W1827800528 cites W2165936034 @default.
• W1827800528 cites W2338813932 @default.
• W1827800528 doi "https://doi.org/10.1242/dev.123.1.415" @default.
• W1827800528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9007259" @default.
• W1827800528 hasPublicationYear "1996" @default.
• W1827800528 type Work @default.
• W1827800528 sameAs 1827800528 @default.
• W1827800528 citedByCount "178" @default.
• W1827800528 countsByYear W18278005282012 @default.
• W1827800528 countsByYear W18278005282013 @default.
• W1827800528 countsByYear W18278005282014 @default.
• W1827800528 countsByYear W18278005282015 @default.
• W1827800528 countsByYear W18278005282016 @default.
• W1827800528 countsByYear W18278005282017 @default.
• W1827800528 countsByYear W18278005282018 @default.
• W1827800528 countsByYear W18278005282019 @default.
• W1827800528 countsByYear W18278005282020 @default.
• W1827800528 countsByYear W18278005282021 @default.
• W1827800528 countsByYear W18278005282022 @default.
• W1827800528 countsByYear W18278005282023 @default.
• W1827800528 crossrefType "journal-article" @default.
• W1827800528 hasAuthorship W1827800528A5012853684 @default.
• W1827800528 hasAuthorship W1827800528A5046141141 @default.
• W1827800528 hasAuthorship W1827800528A5051307830 @default.
• W1827800528 hasAuthorship W1827800528A5067248001 @default.
• W1827800528 hasAuthorship W1827800528A5069574773 @default.
• W1827800528 hasAuthorship W1827800528A5072765144 @default.
• W1827800528 hasConcept C104317684 @default.
• W1827800528 hasConcept C105702510 @default.
• W1827800528 hasConcept C109157449 @default.
• W1827800528 hasConcept C143065580 @default.
• W1827800528 hasConcept C169760540 @default.
• W1827800528 hasConcept C207177822 @default.
• W1827800528 hasConcept C2776878037 @default.
• W1827800528 hasConcept C2777093970 @default.
• W1827800528 hasConcept C2779480072 @default.
• W1827800528 hasConcept C2779530196 @default.
• W1827800528 hasConcept C2780827179 @default.

• next