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- W1827831253 endingPage "885" @default.
- W1827831253 startingPage "872" @default.
- W1827831253 abstract "Strychnine stands out from the group of classical natural products as one of the first complex compounds to be isolated in pure form and an extreme challenge to be structurally characterized. It has played a central role in natural product total syntheses and the surge in the development of innovative synthetic methods for many decades. Recently, we have accomplished one of the shortest formal total syntheses of strychnine (in ten steps and 14% overall yield or even shorter in eight steps and 10% overall yield). The evolution of a productive synthetic strategy, as well as the synthetic challenges tackled, are described here in detail, including examples of related transformations. The successful synthetic strategy was inspired by the premise that the core structure could be derived from simple aromatic indole precursors by a reductive SmI2 -induced ketyl-aryl coupling. Other key reactions included a diastereoselective reduction and a regioselective elimination protocol. Altogether one of the shortest syntheses of iso-strychnine and hence of strychnine was established." @default.
- W1827831253 created "2016-06-24" @default.
- W1827831253 creator A5077129737 @default.
- W1827831253 creator A5081413658 @default.
- W1827831253 date "2015-07-29" @default.
- W1827831253 modified "2023-10-17" @default.
- W1827831253 title "Strychnine as Target, Samarium Diiodide as Tool: A Personal Story" @default.
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