Matches in SemOpenAlex for { <https://semopenalex.org/work/W1827831627> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1827831627 endingPage "21" @default.
- W1827831627 startingPage "21" @default.
- W1827831627 abstract "The formation of acyl-CoA by the action of acyl-CoA synthetases plays a crucial role in membrane lipid turnover, including the plasma membrane of erythrocytes. In human, five Acyl-CoA Synthetase Long-chain (ACSL) genes have been identified with as many as 3 different transcript variants for each.Acyl-CoA Synthetase Long-chain member 6 (ACSL6) is responsible for activation of long-chain fatty acids in erythrocytes. Two additional transcript variants were also isolated from brain and testis. We report the expression in reticulocytes of two new variants and of the one isolated from brain. All three represented different spliced variants of a mutually exclusive exon pair. They encode a slightly different short motif which contains a conserved structural domain, the fatty acid Gate domain. The motifs differ in the presence of either the aromatic residue phenylalanine (Phe) or tyrosine (Tyr). Based on homology, two new isoforms for the closely related ACSL1 were predicted and characterized. One represented a switch of the Phe- to the Tyr-Gate domain motif, the other resulted from the exclusion of both. Swapping of this motif also appears to be common in all mammalian ACSL member 1 and 6 homologs.We propose that a Phe to Tyr substitution or deletion of the Gate domain, is the structural reason for the conserved alternative splicing that affects these motifs. Our findings support our hypothesis that this region is structurally important to define the activity of these enzymes." @default.
- W1827831627 created "2016-06-24" @default.
- W1827831627 creator A5047162260 @default.
- W1827831627 creator A5076972857 @default.
- W1827831627 date "2006-01-01" @default.
- W1827831627 modified "2023-10-15" @default.
- W1827831627 cites W125791290 @default.
- W1827831627 cites W1970458460 @default.
- W1827831627 cites W1979794194 @default.
- W1827831627 cites W2034111644 @default.
- W1827831627 cites W2034767282 @default.
- W1827831627 cites W2037500862 @default.
- W1827831627 cites W2044742054 @default.
- W1827831627 cites W2046118162 @default.
- W1827831627 cites W2058498817 @default.
- W1827831627 cites W2065112197 @default.
- W1827831627 cites W2073636275 @default.
- W1827831627 cites W2093656658 @default.
- W1827831627 cites W2104216656 @default.
- W1827831627 cites W2107903949 @default.
- W1827831627 cites W2112323767 @default.
- W1827831627 cites W2129941226 @default.
- W1827831627 cites W2154582742 @default.
- W1827831627 cites W4230932396 @default.
- W1827831627 cites W204525688 @default.
- W1827831627 doi "https://doi.org/10.1186/1471-2199-7-21" @default.
- W1827831627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1543647" @default.
- W1827831627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16834775" @default.
- W1827831627 hasPublicationYear "2006" @default.
- W1827831627 type Work @default.
- W1827831627 sameAs 1827831627 @default.
- W1827831627 citedByCount "34" @default.
- W1827831627 countsByYear W18278316272012 @default.
- W1827831627 countsByYear W18278316272013 @default.
- W1827831627 countsByYear W18278316272014 @default.
- W1827831627 countsByYear W18278316272015 @default.
- W1827831627 countsByYear W18278316272016 @default.
- W1827831627 countsByYear W18278316272017 @default.
- W1827831627 countsByYear W18278316272020 @default.
- W1827831627 countsByYear W18278316272021 @default.
- W1827831627 countsByYear W18278316272022 @default.
- W1827831627 countsByYear W18278316272023 @default.
- W1827831627 crossrefType "journal-article" @default.
- W1827831627 hasAuthorship W1827831627A5047162260 @default.
- W1827831627 hasAuthorship W1827831627A5076972857 @default.
- W1827831627 hasBestOaLocation W18278316271 @default.
- W1827831627 hasConcept C104317684 @default.
- W1827831627 hasConcept C132677234 @default.
- W1827831627 hasConcept C181199279 @default.
- W1827831627 hasConcept C194583182 @default.
- W1827831627 hasConcept C2776165026 @default.
- W1827831627 hasConcept C36823959 @default.
- W1827831627 hasConcept C53345823 @default.
- W1827831627 hasConcept C54355233 @default.
- W1827831627 hasConcept C54458228 @default.
- W1827831627 hasConcept C55493867 @default.
- W1827831627 hasConcept C67705224 @default.
- W1827831627 hasConcept C86803240 @default.
- W1827831627 hasConceptScore W1827831627C104317684 @default.
- W1827831627 hasConceptScore W1827831627C132677234 @default.
- W1827831627 hasConceptScore W1827831627C181199279 @default.
- W1827831627 hasConceptScore W1827831627C194583182 @default.
- W1827831627 hasConceptScore W1827831627C2776165026 @default.
- W1827831627 hasConceptScore W1827831627C36823959 @default.
- W1827831627 hasConceptScore W1827831627C53345823 @default.
- W1827831627 hasConceptScore W1827831627C54355233 @default.
- W1827831627 hasConceptScore W1827831627C54458228 @default.
- W1827831627 hasConceptScore W1827831627C55493867 @default.
- W1827831627 hasConceptScore W1827831627C67705224 @default.
- W1827831627 hasConceptScore W1827831627C86803240 @default.
- W1827831627 hasIssue "1" @default.
- W1827831627 hasLocation W18278316271 @default.
- W1827831627 hasLocation W18278316272 @default.
- W1827831627 hasLocation W18278316273 @default.
- W1827831627 hasLocation W18278316274 @default.
- W1827831627 hasOpenAccess W1827831627 @default.
- W1827831627 hasPrimaryLocation W18278316271 @default.
- W1827831627 hasRelatedWork W2012312817 @default.
- W1827831627 hasRelatedWork W2023199111 @default.
- W1827831627 hasRelatedWork W2081598294 @default.
- W1827831627 hasRelatedWork W2090969926 @default.
- W1827831627 hasRelatedWork W2321791250 @default.
- W1827831627 hasRelatedWork W2564462691 @default.
- W1827831627 hasRelatedWork W2797310082 @default.
- W1827831627 hasRelatedWork W2904939684 @default.
- W1827831627 hasRelatedWork W4213427798 @default.
- W1827831627 hasRelatedWork W4385462331 @default.
- W1827831627 hasVolume "7" @default.
- W1827831627 isParatext "false" @default.
- W1827831627 isRetracted "false" @default.
- W1827831627 magId "1827831627" @default.
- W1827831627 workType "article" @default.