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• W1827885532 endingPage "C1652" @default.
• W1827885532 startingPage "C1640" @default.
• W1827885532 abstract "Reactive oxygen species (ROS) play an important role in the pathogenesis of many human diseases, including the acute respiratory distress syndrome, Parkinson's disease, pulmonary fibrosis, and Alzheimer's disease. In mammalian cells, several genes known to be induced during the immediate early response to growth factors, including the protooncogenes c-fos and c-myc, have also been shown to be induced by ROS. We show that members of the STAT family of transcription factors, including STAT1 and STAT3, are activated in fibroblasts and A-431 carcinoma cells in response to H2O2. This activation occurs within 5 min, can be inhibited by antioxidants, and does not require protein synthesis. STAT activation in these cell lines is oxidant specific and does not occur in response to superoxide- or nitric oxide-generating stimuli. Buthionine sulfoximine, which depletes intracellular glutathione, also activates the STAT pathway. Moreover, H2O2 stimulates the activity of the known STAT kinases JAK2 and TYK2. Activation of STATs by platelet-derived growth factor (PDGF) is significantly inhibited by N-acetyl-L-cysteine and diphenylene iodonium, indicating that ROS production contributes to STAT activation in response to PDGF. These findings indicate that the JAK-STAT pathway responds to intracellular ROS and that PDGF uses ROS as a second messenger to regulate STAT activation." @default.
• W1827885532 created "2016-06-24" @default.
• W1827885532 creator A5032138489 @default.
• W1827885532 creator A5043413337 @default.
• W1827885532 creator A5051301255 @default.
• W1827885532 creator A5061038965 @default.
• W1827885532 date "1998-12-01" @default.
• W1827885532 modified "2023-10-18" @default.
• W1827885532 title "Activation of the JAK-STAT pathway by reactive oxygen species" @default.
• W1827885532 cites W127609430 @default.
• W1827885532 cites W1480352152 @default.
• W1827885532 cites W1495457417 @default.
• W1827885532 cites W1521367633 @default.
• W1827885532 cites W1539475327 @default.
• W1827885532 cites W1552058470 @default.
• W1827885532 cites W1553277501 @default.
• W1827885532 cites W1568529372 @default.
• W1827885532 cites W1569934864 @default.
• W1827885532 cites W1577403013 @default.
• W1827885532 cites W1659855560 @default.
• W1827885532 cites W1805982011 @default.
• W1827885532 cites W1859005920 @default.
• W1827885532 cites W1949973946 @default.
• W1827885532 cites W1965398762 @default.
• W1827885532 cites W1966551570 @default.
• W1827885532 cites W1969979508 @default.
• W1827885532 cites W1971334092 @default.
• W1827885532 cites W1972603313 @default.
• W1827885532 cites W1979034912 @default.
• W1827885532 cites W1979676829 @default.
• W1827885532 cites W1980632540 @default.
• W1827885532 cites W1981799488 @default.
• W1827885532 cites W1984903682 @default.
• W1827885532 cites W1994479081 @default.
• W1827885532 cites W1996176524 @default.
• W1827885532 cites W1996510577 @default.
• W1827885532 cites W1997935194 @default.
• W1827885532 cites W2003962192 @default.
• W1827885532 cites W2008506838 @default.
• W1827885532 cites W2011342890 @default.
• W1827885532 cites W2012219330 @default.
• W1827885532 cites W2012438019 @default.
• W1827885532 cites W2012744796 @default.
• W1827885532 cites W2016826417 @default.
• W1827885532 cites W2020263041 @default.
• W1827885532 cites W2027286533 @default.
• W1827885532 cites W2030570585 @default.
• W1827885532 cites W2030828553 @default.
• W1827885532 cites W2030865745 @default.
• W1827885532 cites W2032674547 @default.
• W1827885532 cites W2034974668 @default.
• W1827885532 cites W2040328392 @default.
• W1827885532 cites W2041187882 @default.
• W1827885532 cites W2042218061 @default.
• W1827885532 cites W2042360374 @default.
• W1827885532 cites W2043803403 @default.
• W1827885532 cites W2048569323 @default.
• W1827885532 cites W2050465795 @default.
• W1827885532 cites W2051316659 @default.
• W1827885532 cites W2057093252 @default.
• W1827885532 cites W2061587634 @default.
• W1827885532 cites W2061903251 @default.
• W1827885532 cites W2067804511 @default.
• W1827885532 cites W2072569792 @default.
• W1827885532 cites W2074664341 @default.
• W1827885532 cites W2077880395 @default.
• W1827885532 cites W2078499692 @default.
• W1827885532 cites W2083802827 @default.
• W1827885532 cites W2086715846 @default.
• W1827885532 cites W2089878597 @default.
• W1827885532 cites W2090105988 @default.
• W1827885532 cites W2091386218 @default.
• W1827885532 cites W2092217194 @default.
• W1827885532 cites W2093392246 @default.
• W1827885532 cites W2099308977 @default.
• W1827885532 cites W2100869656 @default.
• W1827885532 cites W2101244702 @default.
• W1827885532 cites W2101283727 @default.
• W1827885532 cites W2104251051 @default.
• W1827885532 cites W2107631090 @default.
• W1827885532 cites W2112106256 @default.
• W1827885532 cites W2114375471 @default.
• W1827885532 cites W211546640 @default.
• W1827885532 cites W2119210469 @default.
• W1827885532 cites W2121954647 @default.
• W1827885532 cites W2132633540 @default.
• W1827885532 cites W2137872043 @default.
• W1827885532 cites W2140786721 @default.
• W1827885532 cites W2158748165 @default.
• W1827885532 cites W2160584487 @default.
• W1827885532 cites W2163046152 @default.
• W1827885532 cites W2163856919 @default.
• W1827885532 cites W2164355279 @default.
• W1827885532 cites W2169907805 @default.
• W1827885532 cites W2171759277 @default.
• W1827885532 cites W2172907597 @default.
• W1827885532 cites W2204123985 @default.
• W1827885532 doi "https://doi.org/10.1152/ajpcell.1998.275.6.c1640" @default.

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