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- W1828284507 abstract "Available data suggest that peripheral motion sensitivity in reduced illumination declines with age. OKN data can discriminate glaucoma patients from normals (Severt et al, 2000 Clinical and Experimental Ophthalmology 28 172 - 174). Here, we report age-related rather than disease-related differences in OKN. Vertical gratings of either 0.43 or 1.08 cycles deg-1 drifting at either 5 or 20 deg s-1 and presented at either 8% or 80% contrast were projected onto a large screen viewed at 1.5 m. Gratings were presented as (i) full field stimulation, (ii) central stimulation with gratings presented within a central Gaussian-blurred window of 15 deg diameter, and (iii) peripheral stimulation with gratings presented outside the central 15 deg. All conditions were randomly presented at two light levels: 'mesopic' (1.8 cd m-2) and 'photopic' (71.5 cd m-2). Each trial lasted 20 s, followed by a 25‚s period spent viewing a uniform grey field. Observers were required not to track specific stripes but rather to maintain central fixation. Eye movements were recorded with a 250 Hz SMI Eyelink system and slow phase velocities (SPVs) of the OKN in the last 15 s of each trial were collected. Participants were ten observers in each group: 'young' (mean = 32.3 years, SD = 5.98 years) and 'old' (mean = 65.6 years, SD = 6.53 years) with normal vision and free of ocular disease. There was no overall difference in SPV between the groups. However, for low-contrast, full-field, and high-velocity conditions, there was a significantly larger drop-off in SPV for the older group (photopic mean = 8.9 deg s-1 versus mesopic = 0.36 deg‚s-1) than the younger group (photopic mean = 5.6 deg s-1 versus mesopic = 2.14 deg‚s-1). Taken together, such conditions favour M-pathway sensitivity as determining the reflexive OKN response, suggesting a clear diminution in M-pathway sensitivity in the healthy aging eye. [Supported by Australian Research Council RIEF Grant 2374.]" @default.
- W1828284507 created "2016-06-24" @default.
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- W1828284507 date "2005-01-01" @default.
- W1828284507 modified "2023-09-26" @default.
- W1828284507 title "Mesopic light levels reveal a deficit in reflexive optokinetic nystagmus in older people" @default.
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