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- W1828454705 abstract "Thymic T cell selection mechanisms generate a cross-reactive, self-MHC restricted peripheral T cell pool. Affinity and avidity are of profound influence on this selection and the generation of immunity. Auto-reactive T cells can escape thymic deletion by lowering their avidity, and retain this ‘tuned’ state in the periphery. Upon activation, tuned T cells can cause autoimmunity, while immunotherapeutic strategies may be hampered by existing T cell tolerance. The regulation of T cell avidity and tuning therefore determines the balance between tolerance and autoimmunity and should be taken into account in the design of therapeutic strategies aimed at T cell reactivity." @default.
- W1828454705 created "2016-06-24" @default.
- W1828454705 creator A5067351821 @default.
- W1828454705 date "2010-01-01" @default.
- W1828454705 modified "2023-09-28" @default.
- W1828454705 title "Vitiligo pathogenesis and immunotherapy of melanoma" @default.
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