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- W1828504265 abstract "Roller compaction is a dry granulation process for producing granules from fine powders in order to improve the flowability and homogeneity of pharmaceutical formulations. The flow properties of powder blends will determine how fast they can be fed into the compaction zone and how well they can be densified. In this study, the flow properties of a mixture of microcrystalline cellulose and lactose were varied by changing the concentrations systematically and the flow properties were measured using a ring shear tester, from which the flowability and frictional properties were determined. The produced powder blends were then fed into a laboratory-scale instrumented roller compactor, the flow behaviour was recorded using a video camera and the density distributions of produced ribbons were also characterized. It has been found that there is a good correlation between the flow/no-flow situations during the roller compaction and the flowability measured from the shear cell testing. In particular, for the processing condition considered in this study, the powder blends classified as free flowing pass through the roll gaps freely and cannot be compacted, while the blends classified as easy flowing can be compressed. In addition, it has also found that the density distribution along the ribbon width is dominated by how the powder is fed into the compaction zone." @default.
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- W1828504265 date "2011-01-01" @default.
- W1828504265 modified "2023-09-26" @default.
- W1828504265 title "The Influence of Flow Properties on Roll Compaction behaviour of Pharmaceutical Blends" @default.
- W1828504265 doi "https://doi.org/10.1039/9781849735148-00142" @default.
- W1828504265 hasPublicationYear "2011" @default.
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