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• W1828609470 abstract "A growing amount of data supporting the pathogenic role of the IL-23/IL-17 axis in inflammatory/autoimmune disorders has provided the rationale to target the system for therapeutic purpose. Several compounds have been and are currently under intense investigation in psoriasis and psoriatic arthritis (PsA) yielding impressive results.In this review article, we provide an overview of currently available data on the IL-23/IL-17 system as a target for treatment for psoriasis and PsA. We searched MEDLINE for articles on drug therapy for psoriasis and PsA published between 1 January 2010 and 31 May 2015. One of these agents, ustekinumab, has been recently approved for the treatment of psoriasis and PsA, and a number of IL-23/IL-17-targeted compounds under investigation in these diseases.As our knowledge of the role of the IL-23/IL-17 axis in the pathogenesis of psoriasis and PsA deepens, it enables the development of more targeted therapies in the management of these conditions. Early data on IL-23/IL-17 targeting drugs appear promising, although incomplete. Given the key role IL-23/IL-17 in host defence, the safety profile of targeted drugs should be thoroughly assessed in future studies." @default.
• W1828609470 created "2016-06-24" @default.
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• W1828609470 creator A5085831029 @default.
• W1828609470 date "2015-09-07" @default.
• W1828609470 modified "2023-09-30" @default.
• W1828609470 title "Targeting the IL-23/IL-17 axis for the treatment of psoriasis and psoriatic arthritis" @default.
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• W1828609470 doi "https://doi.org/10.1517/14712598.2015.1084284" @default.
• W1828609470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26653110" @default.
• W1828609470 hasPublicationYear "2015" @default.
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