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• W1828738919 abstract "Reflectance confocal microscopy is successfully used in infant skin research. Infant skin structure, function, and composition are undergoing a maturation process. We aimed to uncover how the epidermal architecture and cellular topology change with time. Images were collected from three age groups of healthy infants between one and four years of age and adults. Cell centers were manually identified on the images at the stratum granulosum (SG) and stratum spinosum (SS) levels. Voronoi diagrams were used to calculate geometrical and topological parameters. Infant cell density is higher than that of adults and decreases with age. Projected cell area, cell perimeter, and average distance to the nearest neighbors increase with age but do so distinctly between the two layers. Structural entropy is different between the two strata, but remains constant with time. For all ages and layers, the distribution of the number of nearest neighbors is typical of a cooperator network architecture. The topological analysis provides evidence of the maturation process in infant skin. The differences between infant and adult are more pronounced in the SG than SS, while cell cooperation is evident in all cases of healthy skin examined." @default.
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• W1828738919 date "2015-09-11" @default.
• W1828738919 modified "2023-10-01" @default.
• W1828738919 title "Geometrical and topological analysis of<i>in vivo</i>confocal microscopy images reveals dynamic maturation of epidermal structures during the first years of life" @default.
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• W1828738919 doi "https://doi.org/10.1117/1.jbo.20.9.095004" @default.
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