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- W1828804799 abstract "Many microbial communities contain organized patterns of cell types, yet relatively little is known about the mechanism or function of this organization. In colonies of the budding yeast Saccharomyces cerevisiae, sporulation occurs in a highly organized pattern, with a top layer of sporulating cells sharply separated from an underlying layer of nonsporulating cells. A mutant screen identified the Mpk1 and Bck1 kinases of the cell-wall integrity (CWI) pathway as specifically required for sporulation in colonies. The CWI pathway was induced as colonies matured, and a target of this pathway, the Rlm1 transcription factor, was activated specifically in the nonsporulating cell layer, here termed feeder cells. Rlm1 stimulates permeabilization of feeder cells and promotes sporulation in an overlying cell layer through a cell-nonautonomous mechanism. The relative fraction of the colony apportioned to feeder cells depends on nutrient environment, potentially buffering sexual reproduction against suboptimal environments." @default.
- W1828804799 created "2016-06-24" @default.
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- W1828804799 date "2015-10-26" @default.
- W1828804799 modified "2023-10-02" @default.
- W1828804799 title "Cell Differentiation and Spatial Organization in Yeast Colonies: Role of Cell-Wall Integrity Pathway" @default.
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- W1828804799 doi "https://doi.org/10.1534/genetics.115.180919" @default.
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