Matches in SemOpenAlex for { <https://semopenalex.org/work/W1828855860> ?p ?o ?g. }
- W1828855860 endingPage "8473" @default.
- W1828855860 startingPage "8454" @default.
- W1828855860 abstract "Urothelial carcinoma, or transitional cell carcinoma, is the most common urologic malignancy that carries significant morbidity, mortality, recurrence risk and associated health care costs. Despite use of current chemotherapies and immunotherapies, long-term remission in patients with muscle-invasive or metastatic disease remains low, and disease recurrence is common. The molecular chaperone Heat Shock Protein-90 (Hsp90) may offer an ideal treatment target, as it is a critical signaling hub in urothelial carcinoma pathogenesis and potentiates chemoradiation. Preclinical testing with Hsp90 inhibitors has demonstrated reduced proliferation, enhanced apoptosis and synergism with chemotherapies and radiation. Despite promising preclinical data, clinical trials utilizing Hsp90 inhibitors for other malignancies had modest efficacy. Therefore, we propose that Hsp90 inhibition would best serve as an adjuvant treatment in advanced muscle-invasive or metastatic bladder cancers to potentiate other therapies. An overview of bladder cancer biology, current treatments, molecular targeted therapies, and the role for Hsp90 inhibitors in the treatment of urothelial carcinoma is the focus of this review." @default.
- W1828855860 created "2016-06-24" @default.
- W1828855860 creator A5007706410 @default.
- W1828855860 creator A5053311104 @default.
- W1828855860 creator A5057529489 @default.
- W1828855860 creator A5058621466 @default.
- W1828855860 creator A5063624667 @default.
- W1828855860 creator A5087916724 @default.
- W1828855860 creator A5088733700 @default.
- W1828855860 date "2015-03-26" @default.
- W1828855860 modified "2023-10-01" @default.
- W1828855860 title "Targeting Hsp90 in urothelial carcinoma" @default.
- W1828855860 cites W1483015025 @default.
- W1828855860 cites W1484388505 @default.
- W1828855860 cites W1496226640 @default.
- W1828855860 cites W1498637512 @default.
- W1828855860 cites W1500178008 @default.
- W1828855860 cites W1519009312 @default.
- W1828855860 cites W1525939594 @default.
- W1828855860 cites W1585804517 @default.
- W1828855860 cites W1725351598 @default.
- W1828855860 cites W1760824447 @default.
- W1828855860 cites W1820014750 @default.
- W1828855860 cites W1920445779 @default.
- W1828855860 cites W1942792521 @default.
- W1828855860 cites W1964847767 @default.
- W1828855860 cites W1965060663 @default.
- W1828855860 cites W1966843521 @default.
- W1828855860 cites W1966900148 @default.
- W1828855860 cites W1968701629 @default.
- W1828855860 cites W1968916175 @default.
- W1828855860 cites W1970681090 @default.
- W1828855860 cites W1971864286 @default.
- W1828855860 cites W1973893663 @default.
- W1828855860 cites W1974206962 @default.
- W1828855860 cites W1975484594 @default.
- W1828855860 cites W1976446632 @default.
- W1828855860 cites W1976786926 @default.
- W1828855860 cites W1976980728 @default.
- W1828855860 cites W1978356732 @default.
- W1828855860 cites W1979129242 @default.
- W1828855860 cites W1980033613 @default.
- W1828855860 cites W1980477405 @default.
- W1828855860 cites W1981597970 @default.
- W1828855860 cites W1982431223 @default.
- W1828855860 cites W1983013270 @default.
- W1828855860 cites W1983287219 @default.
- W1828855860 cites W1984461083 @default.
- W1828855860 cites W1985532753 @default.
- W1828855860 cites W1985921501 @default.
- W1828855860 cites W1987343069 @default.
- W1828855860 cites W1988675578 @default.
- W1828855860 cites W1990058209 @default.
- W1828855860 cites W1991064094 @default.
- W1828855860 cites W1991166887 @default.
- W1828855860 cites W1992756057 @default.
- W1828855860 cites W1993302385 @default.
- W1828855860 cites W1993804787 @default.
- W1828855860 cites W1994679514 @default.
- W1828855860 cites W1995486038 @default.
- W1828855860 cites W1998650136 @default.
- W1828855860 cites W1999397700 @default.
- W1828855860 cites W2002033794 @default.
- W1828855860 cites W2002486813 @default.
- W1828855860 cites W2002851265 @default.
- W1828855860 cites W2003439582 @default.
- W1828855860 cites W2007644670 @default.
- W1828855860 cites W2011162195 @default.
- W1828855860 cites W2012045589 @default.
- W1828855860 cites W2012247982 @default.
- W1828855860 cites W2013592228 @default.
- W1828855860 cites W2014514145 @default.
- W1828855860 cites W2014728404 @default.
- W1828855860 cites W2015606149 @default.
- W1828855860 cites W2015811986 @default.
- W1828855860 cites W2016176308 @default.
- W1828855860 cites W2017054455 @default.
- W1828855860 cites W2018609378 @default.
- W1828855860 cites W2019156893 @default.
- W1828855860 cites W2021343953 @default.
- W1828855860 cites W2021440731 @default.
- W1828855860 cites W2022093187 @default.
- W1828855860 cites W2022254839 @default.
- W1828855860 cites W2022543147 @default.
- W1828855860 cites W2023493483 @default.
- W1828855860 cites W2026226025 @default.
- W1828855860 cites W2028250011 @default.
- W1828855860 cites W2028758612 @default.
- W1828855860 cites W2029132015 @default.
- W1828855860 cites W2029580578 @default.
- W1828855860 cites W2029761703 @default.
- W1828855860 cites W2030279640 @default.
- W1828855860 cites W2031041661 @default.
- W1828855860 cites W2031118938 @default.
- W1828855860 cites W2033775272 @default.
- W1828855860 cites W2035297454 @default.
- W1828855860 cites W2038441129 @default.
- W1828855860 cites W2039500562 @default.