FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1828984543> ?p ?o ?g. }

• W1828984543 abstract "Retinoic acid-inducible gene I (RIG-I) initiates a rapid innate immune response upon detection and binding to viral ribonucleic acid (RNA). This signal activation occurs only when pathogenic RNA is identified, despite the ability of RIG-I to bind endogenous RNA while surveying the cytoplasm. Here we show that ATP binding and hydrolysis by RIG-I play a key role in the identification of viral targets and the activation of signaling. Using biochemical and cell-based assays together with mutagenesis, we show that ATP binding, and not hydrolysis, is required for RIG-I signaling on viral RNA. However, we show that ATP hydrolysis does provide an important function by recycling RIG-I and promoting its dissociation from non-pathogenic RNA. This activity provides a valuable proof-reading mechanism that enhances specificity and prevents an antiviral response upon encounter with host RNA molecules." @default.
• W1828984543 created "2016-06-24" @default.
• W1828984543 creator A5007909912 @default.
• W1828984543 creator A5036389559 @default.
• W1828984543 creator A5076813961 @default.
• W1828984543 date "2015-09-15" @default.
• W1828984543 modified "2023-09-24" @default.
• W1828984543 title "Establishing the role of ATP for the function of the RIG-I innate immune sensor" @default.
• W1828984543 cites W124504601 @default.
• W1828984543 cites W1532807229 @default.
• W1828984543 cites W1965892231 @default.
• W1828984543 cites W1966759986 @default.
• W1828984543 cites W1972784345 @default.
• W1828984543 cites W1973610263 @default.
• W1828984543 cites W1990478192 @default.
• W1828984543 cites W1995707457 @default.
• W1828984543 cites W2007991349 @default.
• W1828984543 cites W2008972769 @default.
• W1828984543 cites W2011383767 @default.
• W1828984543 cites W2011507014 @default.
• W1828984543 cites W2012206989 @default.
• W1828984543 cites W2016194523 @default.
• W1828984543 cites W2017515700 @default.
• W1828984543 cites W2017866593 @default.
• W1828984543 cites W2022687771 @default.
• W1828984543 cites W2024536332 @default.
• W1828984543 cites W2032948492 @default.
• W1828984543 cites W2039294169 @default.
• W1828984543 cites W2040058302 @default.
• W1828984543 cites W2041281845 @default.
• W1828984543 cites W2049424828 @default.
• W1828984543 cites W2053476949 @default.
• W1828984543 cites W2053665358 @default.
• W1828984543 cites W2055342217 @default.
• W1828984543 cites W2057990302 @default.
• W1828984543 cites W2073518639 @default.
• W1828984543 cites W2082586879 @default.
• W1828984543 cites W2089054288 @default.
• W1828984543 cites W2089922680 @default.
• W1828984543 cites W2091362446 @default.
• W1828984543 cites W2096688350 @default.
• W1828984543 cites W2113287929 @default.
• W1828984543 cites W2118980569 @default.
• W1828984543 cites W2123957786 @default.
• W1828984543 cites W2125566625 @default.
• W1828984543 cites W2127832771 @default.
• W1828984543 cites W2135182337 @default.
• W1828984543 cites W2138408665 @default.
• W1828984543 cites W2141137217 @default.
• W1828984543 cites W2149613931 @default.
• W1828984543 cites W2149930662 @default.
• W1828984543 cites W2150058561 @default.
• W1828984543 cites W2156869719 @default.
• W1828984543 cites W2158217876 @default.
• W1828984543 cites W2159829473 @default.
• W1828984543 cites W2160434954 @default.
• W1828984543 cites W2163325684 @default.
• W1828984543 cites W4243831105 @default.
• W1828984543 doi "https://doi.org/10.7554/elife.09391" @default.
• W1828984543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4622095" @default.
• W1828984543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26371557" @default.
• W1828984543 hasPublicationYear "2015" @default.
• W1828984543 type Work @default.
• W1828984543 sameAs 1828984543 @default.
• W1828984543 citedByCount "51" @default.
• W1828984543 countsByYear W18289845432015 @default.
• W1828984543 countsByYear W18289845432016 @default.
• W1828984543 countsByYear W18289845432017 @default.
• W1828984543 countsByYear W18289845432018 @default.
• W1828984543 countsByYear W18289845432019 @default.
• W1828984543 countsByYear W18289845432020 @default.
• W1828984543 countsByYear W18289845432021 @default.
• W1828984543 countsByYear W18289845432022 @default.
• W1828984543 countsByYear W18289845432023 @default.
• W1828984543 crossrefType "journal-article" @default.
• W1828984543 hasAuthorship W1828984543A5007909912 @default.
• W1828984543 hasAuthorship W1828984543A5036389559 @default.
• W1828984543 hasAuthorship W1828984543A5076813961 @default.
• W1828984543 hasBestOaLocation W18289845431 @default.
• W1828984543 hasConcept C104317684 @default.
• W1828984543 hasConcept C136449434 @default.
• W1828984543 hasConcept C141315368 @default.
• W1828984543 hasConcept C170493617 @default.
• W1828984543 hasConcept C181199279 @default.
• W1828984543 hasConcept C23265538 @default.
• W1828984543 hasConcept C2776954689 @default.
• W1828984543 hasConcept C55493867 @default.
• W1828984543 hasConcept C67705224 @default.
• W1828984543 hasConcept C86803240 @default.
• W1828984543 hasConcept C95444343 @default.
• W1828984543 hasConceptScore W1828984543C104317684 @default.
• W1828984543 hasConceptScore W1828984543C136449434 @default.
• W1828984543 hasConceptScore W1828984543C141315368 @default.
• W1828984543 hasConceptScore W1828984543C170493617 @default.
• W1828984543 hasConceptScore W1828984543C181199279 @default.
• W1828984543 hasConceptScore W1828984543C23265538 @default.
• W1828984543 hasConceptScore W1828984543C2776954689 @default.
• W1828984543 hasConceptScore W1828984543C55493867 @default.
• W1828984543 hasConceptScore W1828984543C67705224 @default.
• W1828984543 hasConceptScore W1828984543C86803240 @default.

• next