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- W1829671334 abstract "Chronic obstructive pulmonary disease (COPD) includes a range of changes ranging from chronic bronchitis to emphysema. We evaluated if integration of lung function tests and computed tomography (CT) scan allows a better characterization of patient with COPD. 23 patients (5 females) underwent lung function test and six-minute walk test (6mWT). We used a third-generation, continuous-rotation helical 64-rows CT scanner with volume acquisition to measure extent of emphysema (per cent and absolute value) at full inspiration and at the end of forced expiration. The extent of emphysema corresponding to lung volume with attenuation between -950 and -1024 HU at TLC [Emphysema Index TLC (EITLC)] and RV [Emphysema Index RV (EIRV)] was evaluated. EITLC was 1.21 ± 0.96 L whereas EIRV was equal to 0.76 ± 0.57 L and CT measurements of lung volumes were directly related to static lung volumes. Both EITLC and EIRV were related to the ratios FEV 1 /FVC, FEV 1 (% of predicted), TGV, RV and TLC. Emphysema extent was explained by multiple regression model: EIRV = – 2.12 + 0.02 × ΔAaO 2 + 0.29 × TGV + 0.05 × Expiratory time + 0.28 × Sex (r 2 = 0.75, p = 0.0001) EITLC = – 3.00 + 0.04 × ΔAaO 2 + 0.38 × TLC + 0.31 × Sex (r 2 = 0.49, p = 0.0064). Patients with both EITLC and EIRV > median value of each index showed the emphysema extent related to FEV 1 /FVC, FEF 25-75% and mean SpO 2 during 6mWT. Emphysema, assessed by CT scan, could be explained by lung function measurements reflecting lung hyperinflation and the impairment of pulmonary gas exchange. Emphysema extent, indipendent of lung volume, is related to indices of expiratory flow limitation." @default.
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- W1829671334 date "2012-09-01" @default.
- W1829671334 modified "2023-09-29" @default.
- W1829671334 title "A functional and radiological multiparametric approach to the study of parenchymal features of chronic obstructive pulmonary disease" @default.
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