FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1829681736> ?p ?o ?g. }

• W1829681736 endingPage "4651" @default.
• W1829681736 startingPage "4642" @default.
• W1829681736 abstract "O4(+) oligodendrocyte (OL) progenitors in the mammalian CNS are committed fully to terminal differentiation into myelin-forming cells. In the absence of other cell types in vitro, OL differentiation reproduces the in vivo development with a correct timing, suggesting the existence of an intrinsic regulatory mechanism that presently is unknown. We have examined the effect of two isoforms of the extracellular matrix (ECM) molecule tenascin-R (TN-R), which is expressed by OLs during the process of myelination, on the adhesion and maturation of OLs in vitro. Here we show that the substrate-bound molecules supported the adhesion of O4(+) OLs independently of the CNS region or age from which they were derived. At the molecular level this process was mediated by protein binding to membrane surface sulfatides (Sulf), as indicated by the interference of O4 antibody and Sulf with the attachment of OLs or other Sulf+ cells, erythrocytes, to TN-R substrates and by direct protein-glycolipid binding studies. In the absence of platelet-derived growth factor (PDGF), exogenous TN-R induced myelin gene expression and the upregulation of its own synthesis by cultured cells, resulting in a rapid terminal differentiation of O4(+) progenitors. Our findings strongly suggest that TN-R represents an intrinsic regulatory molecule that controls the timed OL differentiation by an autocrine mechanism and imply the relevance of TN-R for CNS myelination and remyelination." @default.
• W1829681736 created "2016-06-24" @default.
• W1829681736 creator A5004973809 @default.
• W1829681736 creator A5011096032 @default.
• W1829681736 creator A5052344781 @default.
• W1829681736 creator A5068992988 @default.
• W1829681736 date "1997-06-15" @default.
• W1829681736 modified "2023-10-13" @default.
• W1829681736 title "Tenascin-R Is an Intrinsic Autocrine Factor for Oligodendrocyte Differentiation and Promotes Cell Adhesion by a SulfatideMediated Mechanism" @default.
• W1829681736 cites W1442294086 @default.
• W1829681736 cites W1510804202 @default.
• W1829681736 cites W1517566746 @default.
• W1829681736 cites W1539286082 @default.
• W1829681736 cites W1900556344 @default.
• W1829681736 cites W1934567272 @default.
• W1829681736 cites W1944402964 @default.
• W1829681736 cites W1964698371 @default.
• W1829681736 cites W1964834956 @default.
• W1829681736 cites W1966064629 @default.
• W1829681736 cites W1966395272 @default.
• W1829681736 cites W1974967725 @default.
• W1829681736 cites W1978923081 @default.
• W1829681736 cites W1979286083 @default.
• W1829681736 cites W1979953624 @default.
• W1829681736 cites W1985495387 @default.
• W1829681736 cites W1987885030 @default.
• W1829681736 cites W1990286006 @default.
• W1829681736 cites W1991815902 @default.
• W1829681736 cites W1992245559 @default.
• W1829681736 cites W1993335728 @default.
• W1829681736 cites W1997188026 @default.
• W1829681736 cites W1999035185 @default.
• W1829681736 cites W1999217996 @default.
• W1829681736 cites W1999379822 @default.
• W1829681736 cites W2000698657 @default.
• W1829681736 cites W2004219852 @default.
• W1829681736 cites W2006289803 @default.
• W1829681736 cites W2006415052 @default.
• W1829681736 cites W2011122751 @default.
• W1829681736 cites W2011227243 @default.
• W1829681736 cites W2011557383 @default.
• W1829681736 cites W2017775259 @default.
• W1829681736 cites W2020653718 @default.
• W1829681736 cites W2030458862 @default.
• W1829681736 cites W2030517499 @default.
• W1829681736 cites W2031910383 @default.
• W1829681736 cites W2036746355 @default.
• W1829681736 cites W2041165891 @default.
• W1829681736 cites W2042285078 @default.
• W1829681736 cites W2043585611 @default.
• W1829681736 cites W2046434701 @default.
• W1829681736 cites W2047666780 @default.
• W1829681736 cites W2048070937 @default.
• W1829681736 cites W2050258368 @default.
• W1829681736 cites W2050601632 @default.
• W1829681736 cites W2051160606 @default.
• W1829681736 cites W2052623130 @default.
• W1829681736 cites W2054975262 @default.
• W1829681736 cites W2060413384 @default.
• W1829681736 cites W2069350223 @default.
• W1829681736 cites W2074164733 @default.
• W1829681736 cites W2078326745 @default.
• W1829681736 cites W2079806280 @default.
• W1829681736 cites W2081422555 @default.
• W1829681736 cites W2081560586 @default.
• W1829681736 cites W2083140708 @default.
• W1829681736 cites W2084214859 @default.
• W1829681736 cites W2084532990 @default.
• W1829681736 cites W2087733365 @default.
• W1829681736 cites W2089083607 @default.
• W1829681736 cites W2090226055 @default.
• W1829681736 cites W2092547298 @default.
• W1829681736 cites W2093794915 @default.
• W1829681736 cites W2109759840 @default.
• W1829681736 cites W2111570350 @default.
• W1829681736 cites W2112569801 @default.
• W1829681736 cites W2122175586 @default.
• W1829681736 cites W2131651845 @default.
• W1829681736 cites W2131990802 @default.
• W1829681736 cites W2143315617 @default.
• W1829681736 cites W2146121120 @default.
• W1829681736 cites W2149350602 @default.
• W1829681736 cites W2150010887 @default.
• W1829681736 cites W2151483980 @default.
• W1829681736 cites W2151630250 @default.
• W1829681736 cites W2153456852 @default.
• W1829681736 cites W2159425270 @default.
• W1829681736 cites W2165278466 @default.
• W1829681736 cites W2166012856 @default.
• W1829681736 cites W2221064544 @default.
• W1829681736 cites W2267370441 @default.
• W1829681736 cites W2329172261 @default.
• W1829681736 cites W2412174673 @default.
• W1829681736 cites W2416322327 @default.
• W1829681736 cites W4231341273 @default.
• W1829681736 cites W4236771118 @default.
• W1829681736 doi "https://doi.org/10.1523/jneurosci.17-12-04642.1997" @default.
• W1829681736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573339" @default.

• next