FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1829804413> ?p ?o ?g. }

• W1829804413 endingPage "82" @default.
• W1829804413 startingPage "1571" @default.
• W1829804413 abstract "The purpose of this study was to determine whether the expression level of several metastasis-regulating genes correlates with the metastatic potential of human prostate cancer cells implanted into the prostate of nude mice. The steady-state mRNA expression levels for epidermal growth factor receptor (EGFR; growth), basic fibroblast growth factor (bFGF) and interleukin (IL)-8 (angiogenesis), 72-kd and 92-kd type IV collagenase (invasion), E-cadherin (adhesion), and multidrug resistance (mdr-1; drug resistance) were measured by Northern blot and colorimetric in situ hybridization techniques in human PC-3M cells and selected cell variants with different metastatic potentials. Highly metastatic cells growing in culture constitutively and uniformly expressed higher levels of bFGF, IL-8, type IV collagenase, and mdr-1 mRNA transcripts than parental PC-3M cells or low metastatic cells, which displayed a heterogeneous pattern of gene expression. Human prostate cancer cells implanted in nude mice at an ectopic site (subcutaneous) expressed lower levels of EGFR, mdr-1, bFGF, IL-8, and collagenase type IV than those implanted in an orthotopic site (prostate), indicating that the expression of these genes was dependent on the organ environment. Highly metastatic cells growing in the prostate expressed higher levels of EGFR, bFGF, type IV collagenase, and mdr-1 mRNA than low metastatic parental cells in the same site. These data demonstrate a direct correlation between the expression of several metastasis-related genes and the metastatic potential of human prostate cancer cells in nude mice and suggest that multiparametric in situ hybridization analyses can be used to identify the metastatic potential of individual patients' prostate cancers." @default.
• W1829804413 created "2016-06-24" @default.
• W1829804413 creator A5013263748 @default.
• W1829804413 creator A5028562396 @default.
• W1829804413 creator A5043200769 @default.
• W1829804413 creator A5062620521 @default.
• W1829804413 creator A5068197546 @default.
• W1829804413 creator A5070033360 @default.
• W1829804413 date "1997-05-01" @default.
• W1829804413 modified "2023-10-16" @default.
• W1829804413 title "Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique." @default.
• W1829804413 cites W1419228847 @default.
• W1829804413 cites W1462105164 @default.
• W1829804413 cites W1532257606 @default.
• W1829804413 cites W1543319034 @default.
• W1829804413 cites W1555589113 @default.
• W1829804413 cites W1583304743 @default.
• W1829804413 cites W1624649331 @default.
• W1829804413 cites W165132104 @default.
• W1829804413 cites W1714545534 @default.
• W1829804413 cites W1897539317 @default.
• W1829804413 cites W190857994 @default.
• W1829804413 cites W193395684 @default.
• W1829804413 cites W1980637945 @default.
• W1829804413 cites W1995249913 @default.
• W1829804413 cites W1995337883 @default.
• W1829804413 cites W1995368256 @default.
• W1829804413 cites W2014484252 @default.
• W1829804413 cites W2014669590 @default.
• W1829804413 cites W2015292449 @default.
• W1829804413 cites W2016444925 @default.
• W1829804413 cites W2030312997 @default.
• W1829804413 cites W2034713890 @default.
• W1829804413 cites W2047368249 @default.
• W1829804413 cites W2051030392 @default.
• W1829804413 cites W2051819610 @default.
• W1829804413 cites W2055326770 @default.
• W1829804413 cites W2063320563 @default.
• W1829804413 cites W2088130063 @default.
• W1829804413 cites W2095346194 @default.
• W1829804413 cites W2110656326 @default.
• W1829804413 cites W2111033200 @default.
• W1829804413 cites W2113060812 @default.
• W1829804413 cites W2113554746 @default.
• W1829804413 cites W2116161064 @default.
• W1829804413 cites W2120427107 @default.
• W1829804413 cites W2122322546 @default.
• W1829804413 cites W2122794487 @default.
• W1829804413 cites W2134232415 @default.
• W1829804413 cites W2144680000 @default.
• W1829804413 cites W2149734677 @default.
• W1829804413 cites W2164271213 @default.
• W1829804413 cites W2167065480 @default.
• W1829804413 cites W2167621975 @default.
• W1829804413 cites W2312223326 @default.
• W1829804413 cites W2397228914 @default.
• W1829804413 cites W2398023601 @default.
• W1829804413 cites W2406430560 @default.
• W1829804413 cites W2417120763 @default.
• W1829804413 cites W2425176011 @default.
• W1829804413 cites W2466472522 @default.
• W1829804413 cites W304005486 @default.
• W1829804413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1858224" @default.
• W1829804413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9137084" @default.
• W1829804413 hasPublicationYear "1997" @default.
• W1829804413 type Work @default.
• W1829804413 sameAs 1829804413 @default.
• W1829804413 citedByCount "81" @default.
• W1829804413 countsByYear W18298044132015 @default.
• W1829804413 countsByYear W18298044132018 @default.
• W1829804413 countsByYear W18298044132020 @default.
• W1829804413 countsByYear W18298044132021 @default.
• W1829804413 crossrefType "journal-article" @default.
• W1829804413 hasAuthorship W1829804413A5013263748 @default.
• W1829804413 hasAuthorship W1829804413A5028562396 @default.
• W1829804413 hasAuthorship W1829804413A5043200769 @default.
• W1829804413 hasAuthorship W1829804413A5062620521 @default.
• W1829804413 hasAuthorship W1829804413A5068197546 @default.
• W1829804413 hasAuthorship W1829804413A5070033360 @default.
• W1829804413 hasConcept C104317684 @default.
• W1829804413 hasConcept C121608353 @default.
• W1829804413 hasConcept C142724271 @default.
• W1829804413 hasConcept C150194340 @default.
• W1829804413 hasConcept C170493617 @default.
• W1829804413 hasConcept C177707886 @default.
• W1829804413 hasConcept C2775960820 @default.
• W1829804413 hasConcept C2776235491 @default.
• W1829804413 hasConcept C2777587049 @default.
• W1829804413 hasConcept C2779013556 @default.
• W1829804413 hasConcept C2780192828 @default.
• W1829804413 hasConcept C2780278673 @default.
• W1829804413 hasConcept C2780394083 @default.
• W1829804413 hasConcept C502942594 @default.
• W1829804413 hasConcept C54355233 @default.
• W1829804413 hasConcept C55493867 @default.
• W1829804413 hasConcept C71924100 @default.
• W1829804413 hasConcept C81439078 @default.
• W1829804413 hasConcept C81885089 @default.

• next