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• W1830002893 abstract "Colibactin is a potent genotoxin that induces DNA double-strand breaks; it is produced by Escherichia coli strains harboring a pks+ island. However, the structure of this compound remains elusive. Here, using transformation-associated recombination (TAR) cloning to perform heterologous expression, we took advantage of the significantly increased yield of colibactin pathway-related compounds to determine and isolate a series of vital (pre)colibactin intermediates. The chemical structures of compounds 8, 10 and 11 were identified by NMR and MSn analyses. The new 1H-pyrrolo[3,4-c]pyridine-3,6(2H,5H)-dione- and thiazole-containing compound 10 provides new insights regarding the biosynthetic pathway to (pre)colibactin and establishes foundations for future investigation of the intriguing (pre)colibactin structures and its modes of action." @default.
• W1830002893 created "2016-06-24" @default.
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• W1830002893 date "2015-06-26" @default.
• W1830002893 modified "2023-10-01" @default.
• W1830002893 title "Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway" @default.
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• W1830002893 doi "https://doi.org/10.1002/cbic.201500239" @default.
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