FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1830298985> ?p ?o ?g. }

• W1830298985 abstract "Exposure to coarse, fine, and ultrafine particles is associated with adverse population health impacts. We investigated whether size-fractionated particles collected repeatedly in the vicinity of industrial (steel mills and associated coking operations, wastewater treatment), high traffic, and residential areas display systematic differences in biological potency. Particulate matter (PM<0.1, PM0.1–0.5, PM0.5–2.5, PM2.5–10, PM>10) samples collected at sites within Windsor, Ontario, were screened for biological potency in human A549 lung epithelial and murine J774A.1 macrophage-like cells using cytotoxicity bioassays (cellular ATP, resazurin reduction, lactate dehydrogenase (LDH) release), cytokine production, and transcript profiles. Potency was determined from the slope of each dose-effect relationship. Cytotoxic potency varied across size fractions and within a fraction across sites and sampling periods, suggesting that particle composition, in addition to size and mass, affected particle toxicity. While ATP and LDH profiles showed some similarity, resazurin reduction (a measure of metabolic activity) exhibited a unique pattern of response, indicating that the cytotoxicity assays were sensitive to distinct particle characteristics. Chemical speciation varied in relation to prevailing winds, consistent with enrichment of source emissions (e.g. higher metal and polycyclic aromatic hydrocarbon content downwind of the industrial site). Notwithstanding this variability, site-dependent differences in particle toxicity were evident, including greater potency of coarse fractions at the industrial site and of ultrafine particles at the traffic site (Site × Size interactions, p < 0.05). Regression of potency against particle constituents revealed correlations between resazurin reduction, induction of metal-responsive genes, and metal content, which were particularly strong for the coarse fraction, and between cytokine release and endotoxin, suggesting that these factors were important drivers of biological effects that explain, at least in part, the contrasting potencies of particles compared on an equivalent mass basis. The data show that 1) particle potency and composition can exhibit significant temporal variation in relation to source contributions; 2) sources may differentially impact the potency of specific size fractions; and 3) particle constituents, notably metals and endotoxin, may elicit distinct biological responses. Together, the data are consistent with the notion that sources and composition, in addition to size and mass concentration, are relevant to particle toxicity." @default.
• W1830298985 created "2016-06-24" @default.
• W1830298985 creator A5002629392 @default.
• W1830298985 creator A5027156535 @default.
• W1830298985 creator A5038066341 @default.
• W1830298985 creator A5039057044 @default.
• W1830298985 creator A5039435796 @default.
• W1830298985 creator A5044365202 @default.
• W1830298985 creator A5065285323 @default.
• W1830298985 creator A5068493266 @default.
• W1830298985 creator A5079143156 @default.
• W1830298985 creator A5088466132 @default.
• W1830298985 date "2015-07-16" @default.
• W1830298985 modified "2023-10-18" @default.
• W1830298985 title "Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area" @default.
• W1830298985 cites W1901086431 @default.
• W1830298985 cites W1964319442 @default.
• W1830298985 cites W1966030782 @default.
• W1830298985 cites W1966479445 @default.
• W1830298985 cites W1971120393 @default.
• W1830298985 cites W1978883267 @default.
• W1830298985 cites W1982901502 @default.
• W1830298985 cites W1983370210 @default.
• W1830298985 cites W1990120448 @default.
• W1830298985 cites W2004602806 @default.
• W1830298985 cites W2007117895 @default.
• W1830298985 cites W2015541979 @default.
• W1830298985 cites W2017313954 @default.
• W1830298985 cites W2028844202 @default.
• W1830298985 cites W2029496372 @default.
• W1830298985 cites W2036849129 @default.
• W1830298985 cites W2041924905 @default.
• W1830298985 cites W2041999489 @default.
• W1830298985 cites W2042029960 @default.
• W1830298985 cites W2044841374 @default.
• W1830298985 cites W2052788174 @default.
• W1830298985 cites W2059344814 @default.
• W1830298985 cites W2071013498 @default.
• W1830298985 cites W2075211725 @default.
• W1830298985 cites W2084586550 @default.
• W1830298985 cites W2090636204 @default.
• W1830298985 cites W2093161332 @default.
• W1830298985 cites W2094319942 @default.
• W1830298985 cites W2096673955 @default.
• W1830298985 cites W2097183694 @default.
• W1830298985 cites W2098189516 @default.
• W1830298985 cites W2107277218 @default.
• W1830298985 cites W2117386936 @default.
• W1830298985 cites W2123371433 @default.
• W1830298985 cites W2125966967 @default.
• W1830298985 cites W2140513559 @default.
• W1830298985 cites W2142078907 @default.
• W1830298985 cites W2155118487 @default.
• W1830298985 cites W2159885030 @default.
• W1830298985 cites W2160000741 @default.
• W1830298985 cites W2161946971 @default.
• W1830298985 cites W2167905528 @default.
• W1830298985 cites W2192080449 @default.
• W1830298985 cites W220683005 @default.
• W1830298985 cites W2272751124 @default.
• W1830298985 cites W2318698569 @default.
• W1830298985 cites W2320920838 @default.
• W1830298985 cites W2334972472 @default.
• W1830298985 cites W2467625257 @default.
• W1830298985 cites W4241799670 @default.
• W1830298985 cites W4243700785 @default.
• W1830298985 cites W4249331499 @default.
• W1830298985 doi "https://doi.org/10.1186/s12989-015-0099-z" @default.
• W1830298985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4502610" @default.
• W1830298985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26178321" @default.
• W1830298985 hasPublicationYear "2015" @default.
• W1830298985 type Work @default.
• W1830298985 sameAs 1830298985 @default.
• W1830298985 citedByCount "74" @default.
• W1830298985 countsByYear W18302989852016 @default.
• W1830298985 countsByYear W18302989852017 @default.
• W1830298985 countsByYear W18302989852018 @default.
• W1830298985 countsByYear W18302989852019 @default.
• W1830298985 countsByYear W18302989852020 @default.
• W1830298985 countsByYear W18302989852021 @default.
• W1830298985 countsByYear W18302989852022 @default.
• W1830298985 countsByYear W18302989852023 @default.
• W1830298985 crossrefType "journal-article" @default.
• W1830298985 hasAuthorship W1830298985A5002629392 @default.
• W1830298985 hasAuthorship W1830298985A5027156535 @default.
• W1830298985 hasAuthorship W1830298985A5038066341 @default.
• W1830298985 hasAuthorship W1830298985A5039057044 @default.
• W1830298985 hasAuthorship W1830298985A5039435796 @default.
• W1830298985 hasAuthorship W1830298985A5044365202 @default.
• W1830298985 hasAuthorship W1830298985A5065285323 @default.
• W1830298985 hasAuthorship W1830298985A5068493266 @default.
• W1830298985 hasAuthorship W1830298985A5079143156 @default.
• W1830298985 hasAuthorship W1830298985A5088466132 @default.
• W1830298985 hasBestOaLocation W18302989851 @default.
• W1830298985 hasConcept C104488531 @default.
• W1830298985 hasConcept C107872376 @default.
• W1830298985 hasConcept C109316439 @default.
• W1830298985 hasConcept C147789679 @default.
• W1830298985 hasConcept C150032891 @default.
• W1830298985 hasConcept C178790620 @default.

• next