Matches in SemOpenAlex for { <https://semopenalex.org/work/W1830337612> ?p ?o ?g. }
- W1830337612 abstract "Newborn animal studies and pilot studies in humans suggest that mild hypothermia following peripartum hypoxia-ischaemia in newborn infants may reduce neurological sequelae without adverse effects.To determine the effect of therapeutic hypothermia in encephalopathic asphyxiated newborn infants on mortality, long-term neurodevelopmental disability and clinically important side effects.We used the standard search strategy of the Cochrane Neonatal Review Group as outlined in The Cochrane Library (Issue 2, 2007). Randomised controlled trials evaluating therapeutic hypothermia in term and late preterm newborns with hypoxic ischaemic encephalopathy were identified by searching the Oxford Database of Perinatal Trials, the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, 2007, Issue 2), MEDLINE (1966 to June 2007), previous reviews including cross-references, abstracts, conferences, symposia proceedings, expert informants and journal handsearching. We updated this search in May 2012.We included randomised controlled trials comparing the use of therapeutic hypothermia with standard care in encephalopathic term or late preterm infants with evidence of peripartum asphyxia and without recognisable major congenital anomalies. The primary outcome measure was death or long-term major neurodevelopmental disability. Other outcomes included adverse effects of cooling and 'early' indicators of neurodevelopmental outcome.Four review authors independently selected, assessed the quality of and extracted data from the included studies. Study authors were contacted for further information. Meta-analyses were performed using risk ratios (RR) and risk differences (RD) for dichotomous data, and weighted mean difference for continuous data with 95% confidence intervals (CI).We included 11 randomised controlled trials in this updated review, comprising 1505 term and late preterm infants with moderate/severe encephalopathy and evidence of intrapartum asphyxia. Therapeutic hypothermia resulted in a statistically significant and clinically important reduction in the combined outcome of mortality or major neurodevelopmental disability to 18 months of age (typical RR 0.75 (95% CI 0.68 to 0.83); typical RD -0.15, 95% CI -0.20 to -0.10); number needed to treat for an additional beneficial outcome (NNTB) 7 (95% CI 5 to 10) (8 studies, 1344 infants). Cooling also resulted in statistically significant reductions in mortality (typical RR 0.75 (95% CI 0.64 to 0.88), typical RD -0.09 (95% CI -0.13 to -0.04); NNTB 11 (95% CI 8 to 25) (11 studies, 1468 infants) and in neurodevelopmental disability in survivors (typical RR 0.77 (95% CI 0.63 to 0.94), typical RD -0.13 (95% CI -0.19 to -0.07); NNTB 8 (95% CI 5 to 14) (8 studies, 917 infants). Some adverse effects of hypothermia included an increase sinus bradycardia and a significant increase in thrombocytopenia.There is evidence from the 11 randomised controlled trials included in this systematic review (N = 1505 infants) that therapeutic hypothermia is beneficial in term and late preterm newborns with hypoxic ischaemic encephalopathy. Cooling reduces mortality without increasing major disability in survivors. The benefits of cooling on survival and neurodevelopment outweigh the short-term adverse effects. Hypothermia should be instituted in term and late preterm infants with moderate-to-severe hypoxic ischaemic encephalopathy if identified before six hours of age. Further trials to determine the appropriate techniques of cooling, including refinement of patient selection, duration of cooling and method of providing therapeutic hypothermia, will refine our understanding of this intervention." @default.
- W1830337612 created "2016-06-24" @default.
- W1830337612 creator A5029171157 @default.
- W1830337612 creator A5037734812 @default.
- W1830337612 creator A5041821959 @default.
- W1830337612 creator A5042556466 @default.
- W1830337612 creator A5065060309 @default.
- W1830337612 creator A5072261551 @default.
- W1830337612 date "2013-01-31" @default.
- W1830337612 modified "2023-10-09" @default.
- W1830337612 title "Cooling for newborns with hypoxic ischaemic encephalopathy" @default.
- W1830337612 cites W1486686246 @default.
- W1830337612 cites W1527576760 @default.
- W1830337612 cites W1534609067 @default.
- W1830337612 cites W1555612507 @default.
- W1830337612 cites W1714706046 @default.
- W1830337612 cites W1789686003 @default.
- W1830337612 cites W1872204733 @default.
- W1830337612 cites W1928024896 @default.
- W1830337612 cites W1937626966 @default.
- W1830337612 cites W1966923759 @default.
- W1830337612 cites W1969790007 @default.
- W1830337612 cites W1970880133 @default.
- W1830337612 cites W1971193926 @default.
- W1830337612 cites W1971744347 @default.
- W1830337612 cites W1975348053 @default.
- W1830337612 cites W1976395601 @default.
- W1830337612 cites W1976908086 @default.
- W1830337612 cites W1977111115 @default.
- W1830337612 cites W1978708942 @default.
- W1830337612 cites W1980357894 @default.
- W1830337612 cites W1981082943 @default.
- W1830337612 cites W1981276673 @default.
- W1830337612 cites W1981284566 @default.
- W1830337612 cites W1981994271 @default.
- W1830337612 cites W1982944697 @default.
- W1830337612 cites W1983937404 @default.
- W1830337612 cites W1984776205 @default.
- W1830337612 cites W1985848675 @default.
- W1830337612 cites W1987085784 @default.
- W1830337612 cites W1988031743 @default.
- W1830337612 cites W1988501897 @default.
- W1830337612 cites W1990734989 @default.
- W1830337612 cites W1991417152 @default.
- W1830337612 cites W1991576959 @default.
- W1830337612 cites W1992444302 @default.
- W1830337612 cites W1999634864 @default.
- W1830337612 cites W1999737807 @default.
- W1830337612 cites W2009585592 @default.
- W1830337612 cites W2010778898 @default.
- W1830337612 cites W2010904472 @default.
- W1830337612 cites W2011918192 @default.
- W1830337612 cites W2011953489 @default.
- W1830337612 cites W2014642268 @default.
- W1830337612 cites W2015623336 @default.
- W1830337612 cites W2016619395 @default.
- W1830337612 cites W2017140936 @default.
- W1830337612 cites W2017617663 @default.
- W1830337612 cites W2017805386 @default.
- W1830337612 cites W2017952790 @default.
- W1830337612 cites W2022331728 @default.
- W1830337612 cites W2023252093 @default.
- W1830337612 cites W2025091395 @default.
- W1830337612 cites W2028541880 @default.
- W1830337612 cites W2029553801 @default.
- W1830337612 cites W2033493240 @default.
- W1830337612 cites W2037729618 @default.
- W1830337612 cites W2038900954 @default.
- W1830337612 cites W2041646472 @default.
- W1830337612 cites W2045180954 @default.
- W1830337612 cites W2046570531 @default.
- W1830337612 cites W2048517237 @default.
- W1830337612 cites W2049774717 @default.
- W1830337612 cites W2053288742 @default.
- W1830337612 cites W2053525930 @default.
- W1830337612 cites W2055235177 @default.
- W1830337612 cites W2056367822 @default.
- W1830337612 cites W2056393180 @default.
- W1830337612 cites W2061893690 @default.
- W1830337612 cites W2062339571 @default.
- W1830337612 cites W2066017472 @default.
- W1830337612 cites W2069398669 @default.
- W1830337612 cites W2070313257 @default.
- W1830337612 cites W2071497357 @default.
- W1830337612 cites W2073903257 @default.
- W1830337612 cites W2077652064 @default.
- W1830337612 cites W2081331892 @default.
- W1830337612 cites W2082205679 @default.
- W1830337612 cites W2086492121 @default.
- W1830337612 cites W2088288408 @default.
- W1830337612 cites W2089561431 @default.
- W1830337612 cites W2089648703 @default.
- W1830337612 cites W2090425187 @default.
- W1830337612 cites W2091555142 @default.
- W1830337612 cites W2092644972 @default.
- W1830337612 cites W2093157760 @default.
- W1830337612 cites W2098951649 @default.
- W1830337612 cites W2101845946 @default.
- W1830337612 cites W2104098750 @default.
- W1830337612 cites W2104961660 @default.