Matches in SemOpenAlex for { <https://semopenalex.org/work/W1830449750> ?p ?o ?g. }
- W1830449750 abstract "Background Acute kidney injury (AKI) is common in patients undergoing cardiac surgery among whom it is associated with poor outcomes, prolonged hospital stays and increased mortality. Statin drugs can produce more than one effect independent of their lipid lowering effect, and may improve kidney injury through inhibition of postoperative inflammatory responses. Objectives This review aimed to look at the evidence supporting the benefits of perioperative statins for AKI prevention in hospitalised adults after surgery who require cardiac bypass. The main objectives were to 1) determine whether use of statins was associated with preventing AKI development; 2) determine whether use of statins was associated with reductions in in‐hospital mortality; 3) determine whether use of statins was associated with reduced need for RRT; and 4) determine any adverse effects associated with the use of statins. Search methods We searched the Cochrane Renal Group's Specialised Register to 13 January 2015 through contact with the Trials' Search Co‐ordinator using search terms relevant to this review. Selection criteria Randomised controlled trials (RCTs) that compared administration of statin therapy with placebo or standard clinical care in adult patients undergoing surgery requiring cardiopulmonary bypass and reporting AKI, serum creatinine (SCr) or need for renal replacement therapy (RRT) as an outcome were eligible for inclusion. All forms and dosages of statins in conjunction with any duration of pre‐operative therapy were considered for inclusion in this review. Data collection and analysis All authors extracted data independently and assessments were cross‐checked by a second author. Likewise, assessment of study risk of bias was initially conducted by one author and then by a second author to ensure accuracy. Disagreements were arbitrated among authors until consensus was reached. Authors from two of the included studies provided additional data surrounding post‐operative SCr as well as need for RRT. Meta‐analyses were used to assess the outcomes of AKI, SCr and mortality rate. Data for the outcomes of RRT and adverse effects were not pooled. Adverse effects taken into account were those reported by the authors of included studies. Main results We included seven studies (662 participants) in this review. All except one study was assessed as being at high risk of bias. Three studies assessed atorvastatin, three assessed simvastatin and one investigated rosuvastatin. All studies collected data during the immediate perioperative period only; data collection to hospital discharge and postoperative biochemical data collection ranged from 24 hours to 7 days. Overall, pre‐operative statin treatment was not associated with a reduction in postoperative AKI, need for RRT, or mortality. Only two studies (195 participants) reported postoperative SCr level. In those studies, patients allocated to receive statins had lower postoperative SCr concentrations compared with those allocated to no drug treatment/placebo (MD 21.2 µmol/L, 95% CI ‐31.1 to ‐11.1). Adverse effects were adequately reported in only one study; no difference was found between the statin group compared to placebo. Authors' conclusions Analysis of currently available data did not suggest that preoperative statin use is associated with decreased incidence of AKI in adults after surgery who required cardiac bypass. Although a significant reduction in SCr was seen postoperatively in people treated with statins, this result was driven by results from a single study, where SCr was considered as a secondary outcome. The results of the meta‐analysis should be interpreted with caution; few studies were included in subgroup analyses, and significant differences in methodology exist among the included studies. Large high quality RCTs are required to establish the safety and efficacy of statins to prevent AKI after cardiac surgery." @default.
- W1830449750 created "2016-06-24" @default.
- W1830449750 creator A5014950352 @default.
- W1830449750 creator A5025132502 @default.
- W1830449750 creator A5041138678 @default.
- W1830449750 date "2015-03-11" @default.
- W1830449750 modified "2023-09-27" @default.
- W1830449750 title "HMG CoA reductase inhibitors (statins) for preventing acute kidney injury after surgical procedures requiring cardiac bypass" @default.
- W1830449750 cites W1489604524 @default.
- W1830449750 cites W169075001 @default.
- W1830449750 cites W1723736510 @default.
- W1830449750 cites W1963791423 @default.
- W1830449750 cites W1963865655 @default.
- W1830449750 cites W1964120803 @default.
- W1830449750 cites W1965386391 @default.
- W1830449750 cites W1967300023 @default.
- W1830449750 cites W1968410222 @default.
- W1830449750 cites W1969354980 @default.
- W1830449750 cites W1969965827 @default.
- W1830449750 cites W1974190701 @default.
- W1830449750 cites W1974650692 @default.
- W1830449750 cites W1976105077 @default.
- W1830449750 cites W1977644047 @default.
- W1830449750 cites W1977822602 @default.
- W1830449750 cites W1981609895 @default.
- W1830449750 cites W1984610769 @default.
- W1830449750 cites W1986328934 @default.
- W1830449750 cites W1989013715 @default.
- W1830449750 cites W1992982984 @default.
- W1830449750 cites W1994578999 @default.
- W1830449750 cites W2002332553 @default.
- W1830449750 cites W2005040494 @default.
- W1830449750 cites W2010565907 @default.
- W1830449750 cites W2013621779 @default.
- W1830449750 cites W2013852310 @default.
- W1830449750 cites W2014791644 @default.
- W1830449750 cites W2020280677 @default.
- W1830449750 cites W2020675649 @default.
- W1830449750 cites W2025712631 @default.
- W1830449750 cites W2026538502 @default.
- W1830449750 cites W2026670344 @default.
- W1830449750 cites W2028701043 @default.
- W1830449750 cites W2030475349 @default.
- W1830449750 cites W2033442603 @default.
- W1830449750 cites W2033956351 @default.
- W1830449750 cites W2040837356 @default.
- W1830449750 cites W2042220286 @default.
- W1830449750 cites W2042409206 @default.
- W1830449750 cites W2046590737 @default.
- W1830449750 cites W2051000150 @default.
- W1830449750 cites W2051861915 @default.
- W1830449750 cites W2054925118 @default.
- W1830449750 cites W2055439964 @default.
- W1830449750 cites W2057571412 @default.
- W1830449750 cites W2064820555 @default.
- W1830449750 cites W2066553825 @default.
- W1830449750 cites W2066574629 @default.
- W1830449750 cites W2067793131 @default.
- W1830449750 cites W2068012160 @default.
- W1830449750 cites W2071273488 @default.
- W1830449750 cites W2073008365 @default.
- W1830449750 cites W2073403364 @default.
- W1830449750 cites W2074265477 @default.
- W1830449750 cites W2077421021 @default.
- W1830449750 cites W2077447212 @default.
- W1830449750 cites W2080947535 @default.
- W1830449750 cites W2086682468 @default.
- W1830449750 cites W2090639306 @default.
- W1830449750 cites W2091875822 @default.
- W1830449750 cites W2091913907 @default.
- W1830449750 cites W2095079699 @default.
- W1830449750 cites W2096012161 @default.
- W1830449750 cites W2098961381 @default.
- W1830449750 cites W2099280799 @default.
- W1830449750 cites W2105701502 @default.
- W1830449750 cites W2107328434 @default.
- W1830449750 cites W2110431176 @default.
- W1830449750 cites W2111075987 @default.
- W1830449750 cites W2113101136 @default.
- W1830449750 cites W2113123117 @default.
- W1830449750 cites W2113266578 @default.
- W1830449750 cites W2118667643 @default.
- W1830449750 cites W2124752942 @default.
- W1830449750 cites W2125435699 @default.
- W1830449750 cites W2127719007 @default.
- W1830449750 cites W2132547422 @default.
- W1830449750 cites W2134865467 @default.
- W1830449750 cites W2135581707 @default.
- W1830449750 cites W2136191068 @default.
- W1830449750 cites W2139937737 @default.
- W1830449750 cites W2140591698 @default.
- W1830449750 cites W2144623639 @default.
- W1830449750 cites W2147800735 @default.
- W1830449750 cites W2149565359 @default.
- W1830449750 cites W2155132414 @default.
- W1830449750 cites W2155478202 @default.
- W1830449750 cites W2159111147 @default.
- W1830449750 cites W2159999748 @default.
- W1830449750 cites W2161089842 @default.
- W1830449750 cites W2164291537 @default.