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- W1830452011 abstract "The oxidative metabolism of remote phagocytes has been studied during the course of an acute nonspecific inflammation in the mouse. The bone marrow cells (BMC) from mice bearing a polyacrylamide-microbead-induced granuloma (Biogels P4 and P100) show a transient striking decrease of their chemiluminescence (CL) response to opsonized zymosan. This decreased oxidative response occurs between the third and 72nd hr, with a minimum observed at the 24th hr. Bone marrow granulocytes are assessed to represent the main chemiluminescent BMC compartment, using complement-mediated cytotoxicity assays with a monoclonal antimouse granulocyte antibody. Biogel P4-treated mice, but not Biogel P100-treated ones, show at the 24th hr a significantly decreased percentage of segmented bone marrow granulocytes (-45%, P less than .001). The accurate mechanisms involved in this transient suppression of stimulus-induced CL produced by BMC remain to be elucidated." @default.
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- W1830452011 date "1987-07-01" @default.
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- W1830452011 title "Transient Suppression of the Zymosan-Induced Chemiluminescence Produced by Bone Marrow Cells During a Subcutaneous Nonspecific Inflammation in the Mouse" @default.
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- W1830452011 doi "https://doi.org/10.1002/jlb.42.1.76" @default.
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