Matches in SemOpenAlex for { <https://semopenalex.org/work/W1830481063> ?p ?o ?g. }
- W1830481063 endingPage "383001" @default.
- W1830481063 startingPage "383001" @default.
- W1830481063 abstract "The unconstrained genomic DNA of bacteria forms a coil, whose volume exceeds 1000 times the volume of the cell. Since prokaryotes lack a membrane-bound nucleus, in sharp contrast with eukaryotes, the DNA may consequently be expected to occupy the whole available volume when constrained to fit in the cell. Still, it has been known for more than half a century that the DNA is localized in a well-defined region of the cell, called the nucleoid, which occupies only 15% to 25% of the total volume. Although this problem has focused the attention of many scientists in recent decades, there is still no certainty concerning the mechanism that enables such a dramatic compaction. The goal of this Topical Review is to take stock of our knowledge on this question by listing all possible compaction mechanisms with the proclaimed desire to clarify the physical principles they are based upon and discuss them in the light of experimental results and the results of simulations based on coarse-grained models. In particular, the fundamental differences between ψ-condensation and segregative phase separation and between the condensation by small and long polycations are highlighted. This review suggests that the importance of certain mechanisms, like supercoiling and the architectural properties of DNA-bridging and DNA-bending nucleoid proteins, may have been overestimated, whereas other mechanisms, like segregative phase separation and the self-association of nucleoid proteins, as well as the possible role of the synergy of two or more mechanisms, may conversely deserve more attention." @default.
- W1830481063 created "2016-06-24" @default.
- W1830481063 creator A5028173735 @default.
- W1830481063 date "2015-09-08" @default.
- W1830481063 modified "2023-10-18" @default.
- W1830481063 title "Compaction of bacterial genomic DNA: clarifying the concepts" @default.
- W1830481063 cites W1529084957 @default.
- W1830481063 cites W1530522271 @default.
- W1830481063 cites W1533307088 @default.
- W1830481063 cites W1544358773 @default.
- W1830481063 cites W1544991224 @default.
- W1830481063 cites W1659688442 @default.
- W1830481063 cites W1717833723 @default.
- W1830481063 cites W1783552201 @default.
- W1830481063 cites W1965227623 @default.
- W1830481063 cites W1968243053 @default.
- W1830481063 cites W1968512108 @default.
- W1830481063 cites W1968532116 @default.
- W1830481063 cites W1969057307 @default.
- W1830481063 cites W1969114710 @default.
- W1830481063 cites W1971904715 @default.
- W1830481063 cites W1972337026 @default.
- W1830481063 cites W1973174294 @default.
- W1830481063 cites W1975497257 @default.
- W1830481063 cites W1977359391 @default.
- W1830481063 cites W1982937229 @default.
- W1830481063 cites W1983758346 @default.
- W1830481063 cites W1984203911 @default.
- W1830481063 cites W1984381000 @default.
- W1830481063 cites W1984894450 @default.
- W1830481063 cites W1985356820 @default.
- W1830481063 cites W1989470875 @default.
- W1830481063 cites W1992793825 @default.
- W1830481063 cites W1992821930 @default.
- W1830481063 cites W1993045940 @default.
- W1830481063 cites W1997526447 @default.
- W1830481063 cites W1998904980 @default.
- W1830481063 cites W1999119928 @default.
- W1830481063 cites W2001118497 @default.
- W1830481063 cites W2001162607 @default.
- W1830481063 cites W2002645780 @default.
- W1830481063 cites W2004388607 @default.
- W1830481063 cites W2008015588 @default.
- W1830481063 cites W2009843662 @default.
- W1830481063 cites W2018639243 @default.
- W1830481063 cites W2021071879 @default.
- W1830481063 cites W2025267562 @default.
- W1830481063 cites W2027661730 @default.
- W1830481063 cites W2028488968 @default.
- W1830481063 cites W2032284903 @default.
- W1830481063 cites W2033816749 @default.
- W1830481063 cites W2035362991 @default.
- W1830481063 cites W2036203264 @default.
- W1830481063 cites W2037321511 @default.
- W1830481063 cites W2037451631 @default.
- W1830481063 cites W2038222404 @default.
- W1830481063 cites W2040654367 @default.
- W1830481063 cites W2042354277 @default.
- W1830481063 cites W2043341935 @default.
- W1830481063 cites W2043750755 @default.
- W1830481063 cites W2051822822 @default.
- W1830481063 cites W2052498582 @default.
- W1830481063 cites W2052948676 @default.
- W1830481063 cites W2053163492 @default.
- W1830481063 cites W2053328000 @default.
- W1830481063 cites W2054875985 @default.
- W1830481063 cites W2058403397 @default.
- W1830481063 cites W2060758841 @default.
- W1830481063 cites W2061678008 @default.
- W1830481063 cites W2063985312 @default.
- W1830481063 cites W2064863523 @default.
- W1830481063 cites W2066101808 @default.
- W1830481063 cites W2066206042 @default.
- W1830481063 cites W2067229943 @default.
- W1830481063 cites W2067855092 @default.
- W1830481063 cites W2070287692 @default.
- W1830481063 cites W2077442638 @default.
- W1830481063 cites W2081531625 @default.
- W1830481063 cites W2081987320 @default.
- W1830481063 cites W2083278118 @default.
- W1830481063 cites W2086107380 @default.
- W1830481063 cites W2089529435 @default.
- W1830481063 cites W2089689970 @default.
- W1830481063 cites W2097557319 @default.
- W1830481063 cites W2102834112 @default.
- W1830481063 cites W2105110539 @default.
- W1830481063 cites W2105976857 @default.
- W1830481063 cites W2109339776 @default.
- W1830481063 cites W2109811392 @default.
- W1830481063 cites W2114884496 @default.
- W1830481063 cites W2119109353 @default.
- W1830481063 cites W2123419409 @default.
- W1830481063 cites W2127552033 @default.
- W1830481063 cites W2136440044 @default.
- W1830481063 cites W2137419453 @default.
- W1830481063 cites W2139004845 @default.
- W1830481063 cites W2141544847 @default.
- W1830481063 cites W2150990196 @default.