Matches in SemOpenAlex for { <https://semopenalex.org/work/W1830541750> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1830541750 endingPage "174" @default.
- W1830541750 startingPage "165" @default.
- W1830541750 abstract "Traditional clinical monitoring of children with epilepsy does not appear to be sufficiently sensitive to cognitive functioning and behavioral problems. Although subtle, these changes may alter a child's ability to perform well in school and in society. Physicians must prevent seizures without producing intolerable side effects, and ways of more appropriately assessing these side effects must be developed. In this double-blind, counter-balanced, crossover study of 21 children, the effects of phenobarbital and valproic acid on cognitive functioning and behavior were measured. There was no difference in seizure control between the drugs, and each medication was maintained in the therapeutic range for 6 months (mean phenobarbital level, 21.2 µg/mL; mean valproic acid level, 94.1 µg/mL). Children were treated with each drug for 6 months. Differences between the drugs were seen on measurements of cognitive function and behavior. On four tests of neuropsychologic function, children performed significantly less well while receiving phenobarbital (P < .01). There was no evidence that the patients were sedated or less able to perform continuous performance tasks while receiving phenobarbital. Parental assessment of behavior indicated significantly worse behavior with the phenobarbital regimen for three items (P < .01) and children were measureably more hyperactive (P < .05). Routine clinical assessment of the patients did not reveal differences between the drugs with respect to routine laboratory measurements or side effects as assessed by history or physical examination. Although children may appear to tolerate a medication without clinically apparent problems, subtle but significant changes in intellectual function and behavior may be occurring. Additional, more sensitive, methods of monitoring patients while receiving these drugs is necessary." @default.
- W1830541750 created "2016-06-24" @default.
- W1830541750 creator A5003996532 @default.
- W1830541750 creator A5005981281 @default.
- W1830541750 creator A5010841709 @default.
- W1830541750 creator A5027095571 @default.
- W1830541750 creator A5046006279 @default.
- W1830541750 creator A5068158685 @default.
- W1830541750 creator A5080327570 @default.
- W1830541750 date "1987-08-01" @default.
- W1830541750 modified "2023-10-18" @default.
- W1830541750 title "Psychologic and Behavioral Effects of Antiepileptic Drugs in Children: A Double-Blind Comparison Between Phenobarbital and Valproic Acid" @default.
- W1830541750 doi "https://doi.org/10.1542/peds.80.2.165" @default.
- W1830541750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3112727" @default.
- W1830541750 hasPublicationYear "1987" @default.
- W1830541750 type Work @default.
- W1830541750 sameAs 1830541750 @default.
- W1830541750 citedByCount "201" @default.
- W1830541750 countsByYear W18305417502012 @default.
- W1830541750 countsByYear W18305417502013 @default.
- W1830541750 countsByYear W18305417502014 @default.
- W1830541750 countsByYear W18305417502015 @default.
- W1830541750 countsByYear W18305417502016 @default.
- W1830541750 countsByYear W18305417502017 @default.
- W1830541750 countsByYear W18305417502018 @default.
- W1830541750 countsByYear W18305417502019 @default.
- W1830541750 countsByYear W18305417502020 @default.
- W1830541750 countsByYear W18305417502021 @default.
- W1830541750 countsByYear W18305417502022 @default.
- W1830541750 countsByYear W18305417502023 @default.
- W1830541750 crossrefType "journal-article" @default.
- W1830541750 hasAuthorship W1830541750A5003996532 @default.
- W1830541750 hasAuthorship W1830541750A5005981281 @default.
- W1830541750 hasAuthorship W1830541750A5010841709 @default.
- W1830541750 hasAuthorship W1830541750A5027095571 @default.
- W1830541750 hasAuthorship W1830541750A5046006279 @default.
- W1830541750 hasAuthorship W1830541750A5068158685 @default.
- W1830541750 hasAuthorship W1830541750A5080327570 @default.
- W1830541750 hasConcept C118552586 @default.
- W1830541750 hasConcept C126322002 @default.
- W1830541750 hasConcept C169900460 @default.
- W1830541750 hasConcept C187212893 @default.
- W1830541750 hasConcept C2777172819 @default.
- W1830541750 hasConcept C2778186239 @default.
- W1830541750 hasConcept C2778793413 @default.
- W1830541750 hasConcept C2780035454 @default.
- W1830541750 hasConcept C2781413609 @default.
- W1830541750 hasConcept C42219234 @default.
- W1830541750 hasConcept C71924100 @default.
- W1830541750 hasConcept C98274493 @default.
- W1830541750 hasConceptScore W1830541750C118552586 @default.
- W1830541750 hasConceptScore W1830541750C126322002 @default.
- W1830541750 hasConceptScore W1830541750C169900460 @default.
- W1830541750 hasConceptScore W1830541750C187212893 @default.
- W1830541750 hasConceptScore W1830541750C2777172819 @default.
- W1830541750 hasConceptScore W1830541750C2778186239 @default.
- W1830541750 hasConceptScore W1830541750C2778793413 @default.
- W1830541750 hasConceptScore W1830541750C2780035454 @default.
- W1830541750 hasConceptScore W1830541750C2781413609 @default.
- W1830541750 hasConceptScore W1830541750C42219234 @default.
- W1830541750 hasConceptScore W1830541750C71924100 @default.
- W1830541750 hasConceptScore W1830541750C98274493 @default.
- W1830541750 hasIssue "2" @default.
- W1830541750 hasLocation W18305417501 @default.
- W1830541750 hasLocation W18305417502 @default.
- W1830541750 hasOpenAccess W1830541750 @default.
- W1830541750 hasPrimaryLocation W18305417501 @default.
- W1830541750 hasRelatedWork W1595520662 @default.
- W1830541750 hasRelatedWork W1999268383 @default.
- W1830541750 hasRelatedWork W2010374445 @default.
- W1830541750 hasRelatedWork W2040964477 @default.
- W1830541750 hasRelatedWork W2404590016 @default.
- W1830541750 hasRelatedWork W2411816691 @default.
- W1830541750 hasRelatedWork W2790254114 @default.
- W1830541750 hasRelatedWork W2931431712 @default.
- W1830541750 hasRelatedWork W4205439529 @default.
- W1830541750 hasRelatedWork W1564693549 @default.
- W1830541750 hasVolume "80" @default.
- W1830541750 isParatext "false" @default.
- W1830541750 isRetracted "false" @default.
- W1830541750 magId "1830541750" @default.
- W1830541750 workType "article" @default.