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- W1830586809 abstract "Akt is a regulator of cell proliferation, tumorigenesis and apoptosis. This study evaluated the incidence of Akt activation in a subset of neuroendocrine tumors (NETs) and its correlation to clinical pathological parameters.A subset of 46 samples from patients with enteropancreatic NETs (26 male and 20 female) were selected for evaluation. The tissue slides were stained with a mouse monoclonal antiphospho-Akt antibody using the avidin-biotin-complex method.The tumors were from the small (n = 18) and large bowel (n = 9) and from the pancreas (n = 16). Activation of Akt was detected in 61% (28/46) of cases. No statistical correlation was found between the p-Akt score and tumor grade (p = 0.72), tumor size (p = 0.72) and the presence of metastases (p = 0.52).This study shows activation of Akt in a subset of enteropancreatic NET for the first time. This finding suggests a role of p-Akt in NET carcinogenesis." @default.
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- W1830586809 date "2010-12-01" @default.
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- W1830586809 title "Activation of the serine/theronine protein kinase Akt in enteropancreatic neuroendocrine tumors." @default.
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