Matches in SemOpenAlex for { <https://semopenalex.org/work/W1830681812> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1830681812 endingPage "1195" @default.
- W1830681812 startingPage "1186" @default.
- W1830681812 abstract "Mouse thymic virus (TA) is a herpesvirus which produces extensive necrosis of the thymus of newborn mice 7 to 14 days after infection. Infectious virus can be recovered from the thymus for only 10 days after infection, with highest titers occurring between days 5 and 7. In mice 5 days old or less, TA infects thymus cells and produces massive necrosis. TA also infects the salivary glands and persists as a chronic infection. Newborn mice infected with TA have no detectable humoral immune response. Infected adult mice respond, and humoral antibody is detected 7 days after infection. Titers are maintained for months thereafter. Regardless of the age of the mice inoculated with TA, persistent infection was established in the salivary glands, but no evidence for thymus involvement was observed when adults were infected. TA does not cross-react serologically by immunofluorescent, complement fixation, or virus neutralization tests with mouse cytomegalovirus; however, interestingly, the epidemiology of the two herpesviruses are similar. Both mouse cytomegalovirus and TA were isolated from the same animals in populations of laboratory and wild mice. Evidence of infection with mouse cytomegalovirus and TA were most apparent by virus isolations, since humoral antibody responses are rarely observed. All strains of mice tested were susceptible to TA infection. However, in some strains maximum necrosis occurred at 7 days, compared with 10 to 14 days for other strains. The difference in age susceptibility and the target tissue of thymus in newborn mice suggests that TA is a model herpesvirus for studying the effects of viral infections on humoral and cell-mediated immunological functions." @default.
- W1830681812 created "2016-06-24" @default.
- W1830681812 creator A5010818380 @default.
- W1830681812 creator A5059717477 @default.
- W1830681812 creator A5072827787 @default.
- W1830681812 creator A5073880802 @default.
- W1830681812 date "1979-12-01" @default.
- W1830681812 modified "2023-10-16" @default.
- W1830681812 title "Biology of Mouse Thymic Virus, a Herpesvirus of Mice, and the Antigenic Relationship to Mouse Cytomegalovirus" @default.
- W1830681812 cites W1500995897 @default.
- W1830681812 cites W1893963658 @default.
- W1830681812 cites W1923629265 @default.
- W1830681812 cites W1926735004 @default.
- W1830681812 cites W1984631465 @default.
- W1830681812 cites W2089882065 @default.
- W1830681812 doi "https://doi.org/10.1128/iai.26.3.1186-1195.1979" @default.
- W1830681812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/414745" @default.
- W1830681812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/231008" @default.
- W1830681812 hasPublicationYear "1979" @default.
- W1830681812 type Work @default.
- W1830681812 sameAs 1830681812 @default.
- W1830681812 citedByCount "31" @default.
- W1830681812 countsByYear W18306818122012 @default.
- W1830681812 countsByYear W18306818122017 @default.
- W1830681812 countsByYear W18306818122019 @default.
- W1830681812 countsByYear W18306818122020 @default.
- W1830681812 countsByYear W18306818122022 @default.
- W1830681812 crossrefType "journal-article" @default.
- W1830681812 hasAuthorship W1830681812A5010818380 @default.
- W1830681812 hasAuthorship W1830681812A5059717477 @default.
- W1830681812 hasAuthorship W1830681812A5072827787 @default.
- W1830681812 hasAuthorship W1830681812A5073880802 @default.
- W1830681812 hasBestOaLocation W18306818121 @default.
- W1830681812 hasConcept C147483822 @default.
- W1830681812 hasConcept C152669594 @default.
- W1830681812 hasConcept C159047783 @default.
- W1830681812 hasConcept C159654299 @default.
- W1830681812 hasConcept C203014093 @default.
- W1830681812 hasConcept C2522874641 @default.
- W1830681812 hasConcept C2776409557 @default.
- W1830681812 hasConcept C2777662283 @default.
- W1830681812 hasConcept C2777732132 @default.
- W1830681812 hasConcept C2780727368 @default.
- W1830681812 hasConcept C32611913 @default.
- W1830681812 hasConcept C45189115 @default.
- W1830681812 hasConcept C86803240 @default.
- W1830681812 hasConcept C8891405 @default.
- W1830681812 hasConceptScore W1830681812C147483822 @default.
- W1830681812 hasConceptScore W1830681812C152669594 @default.
- W1830681812 hasConceptScore W1830681812C159047783 @default.
- W1830681812 hasConceptScore W1830681812C159654299 @default.
- W1830681812 hasConceptScore W1830681812C203014093 @default.
- W1830681812 hasConceptScore W1830681812C2522874641 @default.
- W1830681812 hasConceptScore W1830681812C2776409557 @default.
- W1830681812 hasConceptScore W1830681812C2777662283 @default.
- W1830681812 hasConceptScore W1830681812C2777732132 @default.
- W1830681812 hasConceptScore W1830681812C2780727368 @default.
- W1830681812 hasConceptScore W1830681812C32611913 @default.
- W1830681812 hasConceptScore W1830681812C45189115 @default.
- W1830681812 hasConceptScore W1830681812C86803240 @default.
- W1830681812 hasConceptScore W1830681812C8891405 @default.
- W1830681812 hasIssue "3" @default.
- W1830681812 hasLocation W18306818121 @default.
- W1830681812 hasLocation W18306818122 @default.
- W1830681812 hasLocation W18306818123 @default.
- W1830681812 hasOpenAccess W1830681812 @default.
- W1830681812 hasPrimaryLocation W18306818121 @default.
- W1830681812 hasRelatedWork W1747302766 @default.
- W1830681812 hasRelatedWork W2017332981 @default.
- W1830681812 hasRelatedWork W2074696208 @default.
- W1830681812 hasRelatedWork W2106142500 @default.
- W1830681812 hasRelatedWork W2113217993 @default.
- W1830681812 hasRelatedWork W2324560112 @default.
- W1830681812 hasRelatedWork W2413664062 @default.
- W1830681812 hasRelatedWork W2422270368 @default.
- W1830681812 hasRelatedWork W2529535941 @default.
- W1830681812 hasRelatedWork W4378628186 @default.
- W1830681812 hasVolume "26" @default.
- W1830681812 isParatext "false" @default.
- W1830681812 isRetracted "false" @default.
- W1830681812 magId "1830681812" @default.
- W1830681812 workType "article" @default.