Matches in SemOpenAlex for { <https://semopenalex.org/work/W1830763485> ?p ?o ?g. }
- W1830763485 abstract "We describe the clinical and therapeutic course of a 51-year-old woman with HER-2+ breast cancer who developed leptomeningeal (LM) and spinal cord metastases after 8 years of stable disease on combination therapy with intravenous (IV) trastuzumab. Due to progressive CNS disease, intrathecal (IT) trastuzumab was introduced to enhance HER-2+ therapy into the CSF space. A combination HER-2+ targeted approach achieved clinical remission with stable disease in our patient 46 months after she was diagnosed with LM metastases. However, spinal cord C-1 metastasis was not fully controlled with IT trastuzumab, ultimately leading to the patient's respiratory compromise. In our patient, IT trastuzumab immunotherapy improved prognosis and was an effective strategy to manage HER-2+ LM disease. Given alone or alongside other anti-HER-2+ therapeutics with sufficient CNS penetration, IT trastuzumab could extend the lifespan of patients with leptomeningeal and CNS metastases." @default.
- W1830763485 created "2016-06-24" @default.
- W1830763485 creator A5008512032 @default.
- W1830763485 creator A5015491002 @default.
- W1830763485 creator A5023485078 @default.
- W1830763485 creator A5029952866 @default.
- W1830763485 creator A5031883615 @default.
- W1830763485 creator A5072177145 @default.
- W1830763485 creator A5074420570 @default.
- W1830763485 date "2015-09-15" @default.
- W1830763485 modified "2023-10-16" @default.
- W1830763485 title "Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient" @default.
- W1830763485 cites W1528402523 @default.
- W1830763485 cites W1967089539 @default.
- W1830763485 cites W1984274637 @default.
- W1830763485 cites W1985981664 @default.
- W1830763485 cites W1987326983 @default.
- W1830763485 cites W1991199939 @default.
- W1830763485 cites W1991228426 @default.
- W1830763485 cites W1992137963 @default.
- W1830763485 cites W1998488881 @default.
- W1830763485 cites W1998694514 @default.
- W1830763485 cites W2005834616 @default.
- W1830763485 cites W2013669698 @default.
- W1830763485 cites W2027373277 @default.
- W1830763485 cites W2040935952 @default.
- W1830763485 cites W2045324973 @default.
- W1830763485 cites W2046356965 @default.
- W1830763485 cites W2095156669 @default.
- W1830763485 cites W2099657378 @default.
- W1830763485 cites W2099711117 @default.
- W1830763485 cites W2115759102 @default.
- W1830763485 cites W2127714076 @default.
- W1830763485 cites W2146384083 @default.
- W1830763485 cites W2159459001 @default.
- W1830763485 cites W2161708183 @default.
- W1830763485 cites W2162453644 @default.
- W1830763485 cites W2165824128 @default.
- W1830763485 cites W2167121370 @default.
- W1830763485 cites W4232529261 @default.
- W1830763485 cites W4239989216 @default.
- W1830763485 cites W4361867966 @default.
- W1830763485 doi "https://doi.org/10.1186/s40425-015-0084-y" @default.
- W1830763485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4570757" @default.
- W1830763485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26380087" @default.
- W1830763485 hasPublicationYear "2015" @default.
- W1830763485 type Work @default.
- W1830763485 sameAs 1830763485 @default.
- W1830763485 citedByCount "26" @default.
- W1830763485 countsByYear W18307634852016 @default.
- W1830763485 countsByYear W18307634852017 @default.
- W1830763485 countsByYear W18307634852018 @default.
- W1830763485 countsByYear W18307634852019 @default.
- W1830763485 countsByYear W18307634852020 @default.
- W1830763485 countsByYear W18307634852021 @default.
- W1830763485 countsByYear W18307634852022 @default.
- W1830763485 crossrefType "journal-article" @default.
- W1830763485 hasAuthorship W1830763485A5008512032 @default.
- W1830763485 hasAuthorship W1830763485A5015491002 @default.
- W1830763485 hasAuthorship W1830763485A5023485078 @default.
- W1830763485 hasAuthorship W1830763485A5029952866 @default.
- W1830763485 hasAuthorship W1830763485A5031883615 @default.
- W1830763485 hasAuthorship W1830763485A5072177145 @default.
- W1830763485 hasAuthorship W1830763485A5074420570 @default.
- W1830763485 hasBestOaLocation W18307634851 @default.
- W1830763485 hasConcept C118552586 @default.
- W1830763485 hasConcept C121608353 @default.
- W1830763485 hasConcept C126322002 @default.
- W1830763485 hasConcept C143998085 @default.
- W1830763485 hasConcept C2775930923 @default.
- W1830763485 hasConcept C2777701055 @default.
- W1830763485 hasConcept C2778231337 @default.
- W1830763485 hasConcept C2779013556 @default.
- W1830763485 hasConcept C2779134260 @default.
- W1830763485 hasConcept C2779786085 @default.
- W1830763485 hasConcept C2780775167 @default.
- W1830763485 hasConcept C530470458 @default.
- W1830763485 hasConcept C71924100 @default.
- W1830763485 hasConceptScore W1830763485C118552586 @default.
- W1830763485 hasConceptScore W1830763485C121608353 @default.
- W1830763485 hasConceptScore W1830763485C126322002 @default.
- W1830763485 hasConceptScore W1830763485C143998085 @default.
- W1830763485 hasConceptScore W1830763485C2775930923 @default.
- W1830763485 hasConceptScore W1830763485C2777701055 @default.
- W1830763485 hasConceptScore W1830763485C2778231337 @default.
- W1830763485 hasConceptScore W1830763485C2779013556 @default.
- W1830763485 hasConceptScore W1830763485C2779134260 @default.
- W1830763485 hasConceptScore W1830763485C2779786085 @default.
- W1830763485 hasConceptScore W1830763485C2780775167 @default.
- W1830763485 hasConceptScore W1830763485C530470458 @default.
- W1830763485 hasConceptScore W1830763485C71924100 @default.
- W1830763485 hasIssue "1" @default.
- W1830763485 hasLocation W18307634851 @default.
- W1830763485 hasLocation W18307634852 @default.
- W1830763485 hasLocation W18307634853 @default.
- W1830763485 hasLocation W18307634854 @default.
- W1830763485 hasOpenAccess W1830763485 @default.
- W1830763485 hasPrimaryLocation W18307634851 @default.
- W1830763485 hasRelatedWork W1722328147 @default.
- W1830763485 hasRelatedWork W188069312 @default.