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• W1830796224 endingPage "e0134576" @default.
• W1830796224 startingPage "e0134576" @default.
• W1830796224 abstract "In June 2013, the first human infection by avian influenza A(H6N1) virus was reported in Taiwan. This incident raised the concern for possible human epidemics and pandemics from H6 viruses. In this study, we performed structural and functional investigation on the hemagglutinin (HA) proteins of the human-infecting A/Taiwan/2/2013(H6N1) (TW H6) virus and an avian A/chicken/Guangdong/S1311/2010(H6N6) (GD H6) virus that transmitted efficiently in guinea pigs. Our results revealed that in the presence of HA1 Q226, the triad of HA1 S137, E190 and G228 in GD H6 HA allows the binding to both avian- and human-like receptors with a slight preference for avian receptors. Its conservation among the majority of H6 HAs provides an explanation for the broader host range of this subtype. Furthermore, the triad of N137, V190 and S228 in TW H6 HA may alleviate the requirement for a hydrophobic residue at HA1 226 of H2 and H3 HAs when binding to human-like receptors. Consequently, TW H6 HA has a slight preference for human receptors, thus may represent an intermediate towards a complete human adaptation. Importantly, the triad observed in TW H6 HA is detected in 74% H6 viruses isolated from Taiwan in the past 14 years, suggesting an elevated threat of H6 viruses from this region to human health. The novel roles of the triad at HA1 137, 190 and 228 of H6 HA in binding to receptors revealed here may also be used by other HA subtypes to achieve human adaptation, which needs to be further tested in laboratory and closely monitored in field surveillance." @default.
• W1830796224 created "2016-06-24" @default.
• W1830796224 creator A5043205706 @default.
• W1830796224 creator A5071316360 @default.
• W1830796224 creator A5087269358 @default.
• W1830796224 date "2015-07-30" @default.
• W1830796224 modified "2023-09-28" @default.
• W1830796224 title "Structural and Functional Studies of Influenza Virus A/H6 Hemagglutinin" @default.
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• W1830796224 doi "https://doi.org/10.1371/journal.pone.0134576" @default.
• W1830796224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4520562" @default.
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• W1830796224 hasPublicationYear "2015" @default.
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