Matches in SemOpenAlex for { <https://semopenalex.org/work/W1830889110> ?p ?o ?g. }
- W1830889110 endingPage "471" @default.
- W1830889110 startingPage "465" @default.
- W1830889110 abstract "Neisseria meningitidis strain M986, which possesses a polyanionic sialic acid capsular polysaccharide, was resistant to the bactericidal effects of normal rabbit serum, but sensitive when immune serum and complement were present. An isogenic strain PRM102, deficient in the ability to produce capsular polysaccharide, was sensitive to normal serum. Strain M986, when grown under conditions of low pH or nutrient limitation, synthesized increased levels of capsular polysaccharide. This was accompanied by an increase in cell surface hydrophilicity and virulence for mice. Cells grown in low-pH, iron-limited medium synthesized the highest concentration of polysaccharide and exhibited the highest cell surface hydrophilicity and virulence among the cases examined. The increase in capsular polysaccharide was partly explained by a decrease in the specific activity of a membrane-bound cytidine monophosphate-N acetylneuraminic acid hydrolase. The results suggest that conditions of nutrient limitation and low pH exert profound effects on the physicochemical nature of the meningococcal cell surface which, in turn, cumulate in enhanced virulence of this organism for mice." @default.
- W1830889110 created "2016-06-24" @default.
- W1830889110 creator A5001267710 @default.
- W1830889110 creator A5018871756 @default.
- W1830889110 date "1985-02-01" @default.
- W1830889110 modified "2023-10-13" @default.
- W1830889110 title "Influence of nutrient limitation and low pH on serogroup B Neisseria meningitidis capsular polysaccharide levels: correlation with virulence for mice" @default.
- W1830889110 cites W1505627834 @default.
- W1830889110 cites W1520467939 @default.
- W1830889110 cites W1607590171 @default.
- W1830889110 cites W1611987859 @default.
- W1830889110 cites W1775749144 @default.
- W1830889110 cites W1792382657 @default.
- W1830889110 cites W1897825357 @default.
- W1830889110 cites W1905745227 @default.
- W1830889110 cites W1920360550 @default.
- W1830889110 cites W1928631547 @default.
- W1830889110 cites W1934958008 @default.
- W1830889110 cites W1944931308 @default.
- W1830889110 cites W1964717752 @default.
- W1830889110 cites W1970276449 @default.
- W1830889110 cites W2000559951 @default.
- W1830889110 cites W2003282939 @default.
- W1830889110 cites W2043666858 @default.
- W1830889110 cites W2046267384 @default.
- W1830889110 cites W2097416100 @default.
- W1830889110 cites W2098806472 @default.
- W1830889110 cites W2112369621 @default.
- W1830889110 cites W2114075164 @default.
- W1830889110 cites W2115350923 @default.
- W1830889110 cites W2118479026 @default.
- W1830889110 cites W2120054497 @default.
- W1830889110 cites W2129900948 @default.
- W1830889110 cites W2133421589 @default.
- W1830889110 cites W2136308359 @default.
- W1830889110 cites W2138677826 @default.
- W1830889110 cites W2139520281 @default.
- W1830889110 cites W2156556290 @default.
- W1830889110 cites W2157994568 @default.
- W1830889110 cites W2164569622 @default.
- W1830889110 cites W2168106585 @default.
- W1830889110 cites W2168140267 @default.
- W1830889110 cites W2170605332 @default.
- W1830889110 cites W2174693442 @default.
- W1830889110 cites W2176189313 @default.
- W1830889110 cites W2178729166 @default.
- W1830889110 cites W2197283467 @default.
- W1830889110 cites W4229712605 @default.
- W1830889110 cites W4242855391 @default.
- W1830889110 doi "https://doi.org/10.1128/iai.47.2.465-471.1985" @default.
- W1830889110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/263193" @default.
- W1830889110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2981773" @default.
- W1830889110 hasPublicationYear "1985" @default.
- W1830889110 type Work @default.
- W1830889110 sameAs 1830889110 @default.
- W1830889110 citedByCount "45" @default.
- W1830889110 countsByYear W18308891102014 @default.
- W1830889110 countsByYear W18308891102015 @default.
- W1830889110 countsByYear W18308891102017 @default.
- W1830889110 countsByYear W18308891102019 @default.
- W1830889110 countsByYear W18308891102023 @default.
- W1830889110 crossrefType "journal-article" @default.
- W1830889110 hasAuthorship W1830889110A5001267710 @default.
- W1830889110 hasAuthorship W1830889110A5018871756 @default.
- W1830889110 hasBestOaLocation W18308891101 @default.
- W1830889110 hasConcept C100817775 @default.
- W1830889110 hasConcept C104317684 @default.
- W1830889110 hasConcept C105702510 @default.
- W1830889110 hasConcept C125235067 @default.
- W1830889110 hasConcept C155292618 @default.
- W1830889110 hasConcept C203014093 @default.
- W1830889110 hasConcept C2777954195 @default.
- W1830889110 hasConcept C2778022156 @default.
- W1830889110 hasConcept C2778458888 @default.
- W1830889110 hasConcept C2780115458 @default.
- W1830889110 hasConcept C2781090273 @default.
- W1830889110 hasConcept C523546767 @default.
- W1830889110 hasConcept C54355233 @default.
- W1830889110 hasConcept C55493867 @default.
- W1830889110 hasConcept C58123911 @default.
- W1830889110 hasConcept C60987743 @default.
- W1830889110 hasConcept C86803240 @default.
- W1830889110 hasConcept C8891405 @default.
- W1830889110 hasConcept C89423630 @default.
- W1830889110 hasConceptScore W1830889110C100817775 @default.
- W1830889110 hasConceptScore W1830889110C104317684 @default.
- W1830889110 hasConceptScore W1830889110C105702510 @default.
- W1830889110 hasConceptScore W1830889110C125235067 @default.
- W1830889110 hasConceptScore W1830889110C155292618 @default.
- W1830889110 hasConceptScore W1830889110C203014093 @default.
- W1830889110 hasConceptScore W1830889110C2777954195 @default.
- W1830889110 hasConceptScore W1830889110C2778022156 @default.
- W1830889110 hasConceptScore W1830889110C2778458888 @default.
- W1830889110 hasConceptScore W1830889110C2780115458 @default.
- W1830889110 hasConceptScore W1830889110C2781090273 @default.
- W1830889110 hasConceptScore W1830889110C523546767 @default.
- W1830889110 hasConceptScore W1830889110C54355233 @default.
- W1830889110 hasConceptScore W1830889110C55493867 @default.