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- W1830893491 abstract "ABSTRACT An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum , is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania ( Viannia ) panamensis . A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis -induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm 2 , 15 min), twice a week for 3 weeks." @default.
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- W1830893491 date "2015-09-01" @default.
- W1830893491 modified "2023-10-18" @default.
- W1830893491 title "Development of a Novel Formulation with Hypericin To Treat Cutaneous Leishmaniasis Based on Photodynamic Therapy in<i>In Vitro</i>and<i>In Vivo</i>Studies" @default.
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- W1830893491 doi "https://doi.org/10.1128/aac.00545-15" @default.
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