Matches in SemOpenAlex for { <https://semopenalex.org/work/W1831381323> ?p ?o ?g. }
- W1831381323 endingPage "1377" @default.
- W1831381323 startingPage "1368" @default.
- W1831381323 abstract "Abstract Background Chronic pain of neuropathic nature after spinal cord injury ( SCI ) is common and its underlying mechanisms are poorly understood. Genes, as well as sex, have been implicated, but not thoroughly investigated in experimental genetic models for complex traits. We have previously found that inbred D ark‐ A gouti ( DA ) rats develop more severe SCI pain‐like behaviour than a major histocompatibility complex‐congenic Piebald Virol Glaxo ( PVG )‐ RT 1 av1 strain in a model of photochemically induced SCI . Methods In this study, a genome‐wide linkage study in an F 2 cross between the susceptible DA and resistant PVG ‐ RT 1 av1 strains was performed in order to explore the influence of genes and sex for SCI pain. Results A consistent finding was that female rats in parental, F 1 and F 2 generations displayed increased pain sensitivity at testing before injury and also developed mechanical hypersensitivity more rapidly and to a greater extent than male rats. In addition, we could identify three quantitative trait loci ( QTLs ) associated with pain‐like behaviour: a sex‐specific QTL on chromosome 2, one on chromosome 15 and on chromosome 6. Animals carrying DA alleles at each of these loci were more susceptible to development of mechanical hypersensitivity compared with rats with PVG alleles. Conclusion This is the first whole genome QTL mapping of neuropathic pain‐like behaviour in a model of SCI . The results provide strong support for a significant genetic and sex component in development of pain after SCI and provide the basis for further genetic dissection and positional cloning of the underlying genes." @default.
- W1831381323 created "2016-06-24" @default.
- W1831381323 creator A5015275115 @default.
- W1831381323 creator A5028058399 @default.
- W1831381323 creator A5038990969 @default.
- W1831381323 creator A5040789499 @default.
- W1831381323 creator A5052603062 @default.
- W1831381323 creator A5055926195 @default.
- W1831381323 creator A5056388603 @default.
- W1831381323 creator A5081657251 @default.
- W1831381323 date "2012-04-04" @default.
- W1831381323 modified "2023-10-16" @default.
- W1831381323 title "Genetic and sex influence on neuropathic pain‐like behaviour after spinal cord injury in the rat" @default.
- W1831381323 cites W1534204769 @default.
- W1831381323 cites W1967162890 @default.
- W1831381323 cites W1968371711 @default.
- W1831381323 cites W1971259292 @default.
- W1831381323 cites W1972130920 @default.
- W1831381323 cites W1974535150 @default.
- W1831381323 cites W1981251766 @default.
- W1831381323 cites W1982115147 @default.
- W1831381323 cites W1983979046 @default.
- W1831381323 cites W1986237413 @default.
- W1831381323 cites W1988319415 @default.
- W1831381323 cites W1990906777 @default.
- W1831381323 cites W1997479959 @default.
- W1831381323 cites W1998798962 @default.
- W1831381323 cites W2000492372 @default.
- W1831381323 cites W2000518252 @default.
- W1831381323 cites W2011934595 @default.
- W1831381323 cites W2017006044 @default.
- W1831381323 cites W2028185828 @default.
- W1831381323 cites W2031447224 @default.
- W1831381323 cites W2036920764 @default.
- W1831381323 cites W2041731718 @default.
- W1831381323 cites W2051341512 @default.
- W1831381323 cites W2058553345 @default.
- W1831381323 cites W2059819603 @default.
- W1831381323 cites W2064610122 @default.
- W1831381323 cites W2069484052 @default.
- W1831381323 cites W2073162601 @default.
- W1831381323 cites W2082241876 @default.
- W1831381323 cites W2083833406 @default.
- W1831381323 cites W2085502426 @default.
- W1831381323 cites W2087617104 @default.
- W1831381323 cites W2089947119 @default.
- W1831381323 cites W2097639794 @default.
- W1831381323 cites W2101010807 @default.
- W1831381323 cites W2104335028 @default.
- W1831381323 cites W2116053845 @default.
- W1831381323 cites W2116805033 @default.
- W1831381323 cites W2123941730 @default.
- W1831381323 cites W2125860227 @default.
- W1831381323 cites W2135540915 @default.
- W1831381323 cites W2135946349 @default.
- W1831381323 cites W2136961324 @default.
- W1831381323 cites W2139898757 @default.
- W1831381323 cites W2149756965 @default.
- W1831381323 cites W2168132586 @default.
- W1831381323 cites W2493658357 @default.
- W1831381323 doi "https://doi.org/10.1002/j.1532-2149.2012.00144.x" @default.
- W1831381323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22473909" @default.
- W1831381323 hasPublicationYear "2012" @default.
- W1831381323 type Work @default.
- W1831381323 sameAs 1831381323 @default.
- W1831381323 citedByCount "22" @default.
- W1831381323 countsByYear W18313813232013 @default.
- W1831381323 countsByYear W18313813232014 @default.
- W1831381323 countsByYear W18313813232015 @default.
- W1831381323 countsByYear W18313813232017 @default.
- W1831381323 countsByYear W18313813232018 @default.
- W1831381323 countsByYear W18313813232019 @default.
- W1831381323 countsByYear W18313813232020 @default.
- W1831381323 countsByYear W18313813232021 @default.
- W1831381323 countsByYear W18313813232022 @default.
- W1831381323 countsByYear W18313813232023 @default.
- W1831381323 crossrefType "journal-article" @default.
- W1831381323 hasAuthorship W1831381323A5015275115 @default.
- W1831381323 hasAuthorship W1831381323A5028058399 @default.
- W1831381323 hasAuthorship W1831381323A5038990969 @default.
- W1831381323 hasAuthorship W1831381323A5040789499 @default.
- W1831381323 hasAuthorship W1831381323A5052603062 @default.
- W1831381323 hasAuthorship W1831381323A5055926195 @default.
- W1831381323 hasAuthorship W1831381323A5056388603 @default.
- W1831381323 hasAuthorship W1831381323A5081657251 @default.
- W1831381323 hasConcept C104317684 @default.
- W1831381323 hasConcept C142870003 @default.
- W1831381323 hasConcept C169760540 @default.
- W1831381323 hasConcept C180754005 @default.
- W1831381323 hasConcept C207936829 @default.
- W1831381323 hasConcept C2777107010 @default.
- W1831381323 hasConcept C2778334475 @default.
- W1831381323 hasConcept C2780775167 @default.
- W1831381323 hasConcept C2781118164 @default.
- W1831381323 hasConcept C30481170 @default.
- W1831381323 hasConcept C54355233 @default.
- W1831381323 hasConcept C71924100 @default.
- W1831381323 hasConcept C81941488 @default.