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• W1831474080 abstract "The protein-coding regions of most vertebrate genes are split, giving rise to primary transcripts containing introns and exons; the latter must be spliced in the nucleus to form the mature mRNA, which then moves to the cytoplasm for translation. Pre-mRNA splicing, the process of intron removal and exon joining, represents an important function within the nucleus, and elucidation of the mechanisms of splicing has challenged researchers since the discovery of segmented genes. A surprising discovery was that many genes have the capacity to encode multiple protein products as a consequence of alternative splicing events. Thus, a great deal of interest centers around characterizing the mechanisms whereby multiple mRNAs can derive from a common pre-mRNA, especially those events which exhibit celland/or tissue-specific regulation. Important advances have been made recently, with the identification of trans-acting factors that can modulate splice site choice in vitro. However, much of this work stems directly from the tremendous progress that is being made in the characterization of the factors involved in constitutive splicing. The ability of whole cell and nuclear extracts to perform intron removal and exon ligation events has led to the rapid development of a detailed outline of the steps involved in mRNA splicing (reviewed by Green, 1991; Krainer and Maniatis, 1988; Sharp, 1987). Each intron is removed in a twostep process (Fig. 1). First, cleavage at the boundary between the intron and the exon upstream (the 5′ splice site or splice donor) occurs, with concomitant joining of the 5′ phosphate at the 5′ splice site to a 2′ hydroxyl of a residue within the intron, forming a branched nucleotide. This lariat intermediate undergoes cleavage at the junction between the intron and the downstream exon (the 3′ splice site or splice acceptor), with the coordinated ligation of the two free exons to form mature mRNA and the liberation of the lariat intron. In cases of alternative splicing, exons may have multiple 5′ or 3′ splice sites, may be entirely skipped, and introns may be retained; some examples are diagrammed in Fig. 2 (see also McKeown, 1992; Smith et al., 1989)." @default.
• W1831474080 created "2016-06-24" @default.
• W1831474080 creator A5038038114 @default.
• W1831474080 date "1994-01-01" @default.
• W1831474080 modified "2023-10-09" @default.
• W1831474080 title "Alternative pre-mrna splicing: Factors involved in splice site selection" @default.
• W1831474080 cites W131136481 @default.
• W1831474080 cites W1530353793 @default.
• W1831474080 cites W1545060567 @default.
• W1831474080 cites W1557189154 @default.
• W1831474080 cites W1567606707 @default.
• W1831474080 cites W1569911890 @default.
• W1831474080 cites W1647720439 @default.
• W1831474080 cites W1750913658 @default.
• W1831474080 cites W1888362621 @default.
• W1831474080 cites W1965208181 @default.
• W1831474080 cites W1966123525 @default.
• W1831474080 cites W1969039078 @default.
• W1831474080 cites W1971956957 @default.
• W1831474080 cites W1971981203 @default.
• W1831474080 cites W1975580175 @default.
• W1831474080 cites W1979455742 @default.
• W1831474080 cites W1979937918 @default.
• W1831474080 cites W1980428104 @default.
• W1831474080 cites W1982110415 @default.
• W1831474080 cites W1983271049 @default.
• W1831474080 cites W1985576809 @default.
• W1831474080 cites W1986297742 @default.
• W1831474080 cites W1988271866 @default.
• W1831474080 cites W1989109522 @default.
• W1831474080 cites W1993243592 @default.
• W1831474080 cites W2002944098 @default.
• W1831474080 cites W2003134182 @default.
• W1831474080 cites W2008913071 @default.
• W1831474080 cites W2008932218 @default.
• W1831474080 cites W2010443948 @default.
• W1831474080 cites W2013002081 @default.
• W1831474080 cites W2013955971 @default.
• W1831474080 cites W2014427312 @default.
• W1831474080 cites W2014791263 @default.
• W1831474080 cites W2015221277 @default.
• W1831474080 cites W2015415328 @default.
• W1831474080 cites W2023218737 @default.
• W1831474080 cites W2024170620 @default.
• W1831474080 cites W2024588724 @default.
• W1831474080 cites W2027183714 @default.
• W1831474080 cites W2031130109 @default.
• W1831474080 cites W2031156037 @default.
• W1831474080 cites W2039762550 @default.
• W1831474080 cites W2041847911 @default.
• W1831474080 cites W2043307368 @default.
• W1831474080 cites W2044522020 @default.
• W1831474080 cites W2046179244 @default.
• W1831474080 cites W2049847998 @default.
• W1831474080 cites W2050152103 @default.
• W1831474080 cites W2055492153 @default.
• W1831474080 cites W2057479447 @default.
• W1831474080 cites W2060249670 @default.
• W1831474080 cites W2061224677 @default.
• W1831474080 cites W2061772859 @default.
• W1831474080 cites W2066552951 @default.
• W1831474080 cites W2068898003 @default.
• W1831474080 cites W2069101074 @default.
• W1831474080 cites W2069252364 @default.
• W1831474080 cites W2076530408 @default.
• W1831474080 cites W2076944748 @default.
• W1831474080 cites W2079440494 @default.
• W1831474080 cites W2081201806 @default.
• W1831474080 cites W2082127202 @default.
• W1831474080 cites W2091955128 @default.
• W1831474080 cites W2094972420 @default.
• W1831474080 cites W2097531178 @default.
• W1831474080 cites W2100179968 @default.
• W1831474080 cites W2101679570 @default.
• W1831474080 cites W2103886753 @default.
• W1831474080 cites W2104788940 @default.
• W1831474080 cites W2122071753 @default.
• W1831474080 cites W2124947814 @default.
• W1831474080 cites W2125304732 @default.
• W1831474080 cites W2132978049 @default.
• W1831474080 cites W2133143001 @default.
• W1831474080 cites W2135466312 @default.
• W1831474080 cites W2139727828 @default.
• W1831474080 cites W214734757 @default.
• W1831474080 cites W2166724094 @default.
• W1831474080 cites W2166832632 @default.
• W1831474080 cites W2170255408 @default.
• W1831474080 cites W2173963963 @default.
• W1831474080 cites W4210987884 @default.
• W1831474080 cites W4236484150 @default.
• W1831474080 cites W4246499043 @default.
• W1831474080 cites W4379410178 @default.
• W1831474080 cites W92004496 @default.
• W1831474080 doi "https://doi.org/10.1242/jcs.107.1.1" @default.
• W1831474080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8175901" @default.
• W1831474080 hasPublicationYear "1994" @default.
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