Matches in SemOpenAlex for { <https://semopenalex.org/work/W1831484906> ?p ?o ?g. }
- W1831484906 endingPage "217" @default.
- W1831484906 startingPage "212" @default.
- W1831484906 abstract "Inflammation plays a pivotal role in the pathogenesis of atherosclerosis. Interleukin (IL) 6 has many inflammatory functions, and the IL-6 -174 G/C promoter polymorphism appears to influence IL-6 levels. Findings of previous studies on the relation between this polymorphism and risk of cardiovascular diseases are inconsistent. We investigated this polymorphism in relation to risk of coronary heart disease (CHD) in a population-based study and meta-analysis.Participants (6434) of the Rotterdam Study were genotyped. Analyses on the relation between genotype and CHD were performed using Cox proportional hazards tests, and the association between genotype and plasma levels of IL-6 and C-reactive protein was investigated. All of the analyses were adjusted for age, sex, and common cardiovascular risk factors. A meta-analysis was performed, using a random effects model. No association between genotype and risk of CHD was observed. The polymorphism was not associated with IL-6 levels, but the C-allele was associated with higher C-reactive protein levels (P<0.01). Our meta-analysis did not show a significant association between the genotype and risk of CHD.We conclude that the polymorphism is not a suitable genetic marker for increased risk of CHD in subjects > or =55 years of age." @default.
- W1831484906 created "2016-06-24" @default.
- W1831484906 creator A5002923409 @default.
- W1831484906 creator A5017009749 @default.
- W1831484906 creator A5031530236 @default.
- W1831484906 creator A5039022390 @default.
- W1831484906 creator A5039611937 @default.
- W1831484906 creator A5050357804 @default.
- W1831484906 creator A5068004396 @default.
- W1831484906 creator A5070713168 @default.
- W1831484906 date "2006-01-01" @default.
- W1831484906 modified "2023-10-12" @default.
- W1831484906 title "Interleukin 6 −174 G/C Promoter Polymorphism and Risk of Coronary Heart Disease" @default.
- W1831484906 cites W1973293258 @default.
- W1831484906 cites W1978298539 @default.
- W1831484906 cites W1983297804 @default.
- W1831484906 cites W1993966022 @default.
- W1831484906 cites W1995623538 @default.
- W1831484906 cites W2003165120 @default.
- W1831484906 cites W2005571403 @default.
- W1831484906 cites W2026289810 @default.
- W1831484906 cites W2049504412 @default.
- W1831484906 cites W2049768059 @default.
- W1831484906 cites W2053927949 @default.
- W1831484906 cites W2057478159 @default.
- W1831484906 cites W2058709767 @default.
- W1831484906 cites W2058956957 @default.
- W1831484906 cites W2084296671 @default.
- W1831484906 cites W2086707179 @default.
- W1831484906 cites W2089022749 @default.
- W1831484906 cites W2091200286 @default.
- W1831484906 cites W2095928540 @default.
- W1831484906 cites W2100419955 @default.
- W1831484906 cites W2101613341 @default.
- W1831484906 cites W2102157578 @default.
- W1831484906 cites W2107328434 @default.
- W1831484906 cites W2126607855 @default.
- W1831484906 cites W2128675119 @default.
- W1831484906 cites W2142585662 @default.
- W1831484906 cites W2152298449 @default.
- W1831484906 cites W2154616402 @default.
- W1831484906 cites W2160776746 @default.
- W1831484906 cites W2285706403 @default.
- W1831484906 cites W2324841714 @default.
- W1831484906 cites W2615584519 @default.
- W1831484906 doi "https://doi.org/10.1161/01.atv.0000194099.65024.17" @default.
- W1831484906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16269662" @default.
- W1831484906 hasPublicationYear "2006" @default.
- W1831484906 type Work @default.
- W1831484906 sameAs 1831484906 @default.
- W1831484906 citedByCount "99" @default.
- W1831484906 countsByYear W18314849062012 @default.
- W1831484906 countsByYear W18314849062013 @default.
- W1831484906 countsByYear W18314849062014 @default.
- W1831484906 countsByYear W18314849062015 @default.
- W1831484906 countsByYear W18314849062016 @default.
- W1831484906 countsByYear W18314849062018 @default.
- W1831484906 countsByYear W18314849062019 @default.
- W1831484906 countsByYear W18314849062020 @default.
- W1831484906 countsByYear W18314849062021 @default.
- W1831484906 countsByYear W18314849062022 @default.
- W1831484906 crossrefType "journal-article" @default.
- W1831484906 hasAuthorship W1831484906A5002923409 @default.
- W1831484906 hasAuthorship W1831484906A5017009749 @default.
- W1831484906 hasAuthorship W1831484906A5031530236 @default.
- W1831484906 hasAuthorship W1831484906A5039022390 @default.
- W1831484906 hasAuthorship W1831484906A5039611937 @default.
- W1831484906 hasAuthorship W1831484906A5050357804 @default.
- W1831484906 hasAuthorship W1831484906A5068004396 @default.
- W1831484906 hasAuthorship W1831484906A5070713168 @default.
- W1831484906 hasBestOaLocation W18314849061 @default.
- W1831484906 hasConcept C104317684 @default.
- W1831484906 hasConcept C126322002 @default.
- W1831484906 hasConcept C135763542 @default.
- W1831484906 hasConcept C149737253 @default.
- W1831484906 hasConcept C180754005 @default.
- W1831484906 hasConcept C2776914184 @default.
- W1831484906 hasConcept C2779134260 @default.
- W1831484906 hasConcept C2780942790 @default.
- W1831484906 hasConcept C2781195455 @default.
- W1831484906 hasConcept C2992519594 @default.
- W1831484906 hasConcept C54355233 @default.
- W1831484906 hasConcept C71924100 @default.
- W1831484906 hasConcept C86803240 @default.
- W1831484906 hasConcept C95190672 @default.
- W1831484906 hasConceptScore W1831484906C104317684 @default.
- W1831484906 hasConceptScore W1831484906C126322002 @default.
- W1831484906 hasConceptScore W1831484906C135763542 @default.
- W1831484906 hasConceptScore W1831484906C149737253 @default.
- W1831484906 hasConceptScore W1831484906C180754005 @default.
- W1831484906 hasConceptScore W1831484906C2776914184 @default.
- W1831484906 hasConceptScore W1831484906C2779134260 @default.
- W1831484906 hasConceptScore W1831484906C2780942790 @default.
- W1831484906 hasConceptScore W1831484906C2781195455 @default.
- W1831484906 hasConceptScore W1831484906C2992519594 @default.
- W1831484906 hasConceptScore W1831484906C54355233 @default.
- W1831484906 hasConceptScore W1831484906C71924100 @default.
- W1831484906 hasConceptScore W1831484906C86803240 @default.