Matches in SemOpenAlex for { <https://semopenalex.org/work/W1831487034> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1831487034 endingPage "656" @default.
- W1831487034 startingPage "650" @default.
- W1831487034 abstract "내피세포 단백질 C 수용체(EPCR)가 트롬빈-트롬보모듈린 복합체에 의한 단백질 C (PC) 활성 증가에 중요한 역할을 한다. EPCR의 활성은 ecodomain의 분열과 수용성 단백질(sEPCR)로 분비함으로써 현저하게 변화한다. EPCR의 탈락은 tumor necrosis factor-<TEX>${alpha}$</TEX> converting enzyme (TACE)에 의해 매개된다. 토마토에서 발견된 라이코펜은 항산화 효과, 항암 효과, 항염증 효과를 가지고 있다. 그러나 EPCR 탈락에서의 라이코펜의 효과는 알려지지 않았다. 우리는 라이코펜이 PMA, TNF-<TEX>${alpha}$</TEX>, IL-<TEX>$1{beta}$</TEX>와 CLP에 의해 유도된 EPCR 탈락에 미치는 영향을 연구했다. 그 결과, 라이코펜은 TACE의 발현을 억제시켜 PMA, TNF-<TEX>${alpha}$</TEX>, IL-<TEX>$1{beta}$</TEX>와 CLP에 의해 매개된 EPCR 탈락을 저해함을 보여준다. 또한 라이코펜은 PMA가 유발한 p38, ERK1/2, JNK의 인산화를 감소시켰다. 이러한 결과를 토대로, 라이코펜은 EPCR 탈락의 저해를 통해 다양한 중증 혈관 염증 질병 치료를 위한 후보 물질이 될 수 있을 것이다. Endothelial protein C receptor (EPCR) plays a pivotal role in augmenting Protein C activation through the thrombin-thrombomodulin complex. EPCR activity is markedly changed by ectodomain cleavage and released as the soluble protein (sEPCR). EPCR shedding is mediated by tumor necrosis factor-<TEX>${alpha}$</TEX> converting enzyme (TACE). Lycopene found in tomatoes and tomato products has anti-oxidant, anti- cancer and anti-inflammatory effects. However, little is known about the effects of lycopene on EPCR shedding. We investigated this issue by monitoring the effects of lycopene on the phorbol-12-myristate 13-acetate (PMA), tumor necrosis factor (TNF)-<TEX>${alpha}$</TEX>, interleukin (IL)-<TEX>$1{beta}$</TEX> and on the cecal ligation and puncture (CLP)-mediated EPCR shedding. Data showed that lycopene potently inhibited the PMA, TNF-<TEX>${alpha}$</TEX>, IL-<TEX>$1{beta}$</TEX> and CLP-induced EPCR shedding by suppressing TACE expression. Furthermore, lycopene reduced PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2 and c-Jun N-terminal kinase (JNK). Given these results, lycopene should be viewed as a candidate therapeutic agent for the treatment of various severe vascular inflammatory diseases via inhibition of the EPCR shedding." @default.
- W1831487034 created "2016-06-24" @default.
- W1831487034 creator A5005439728 @default.
- W1831487034 creator A5007125221 @default.
- W1831487034 creator A5040436938 @default.
- W1831487034 creator A5042460370 @default.
- W1831487034 date "2013-05-30" @default.
- W1831487034 modified "2023-10-17" @default.
- W1831487034 title "Effects of Lycopene on Endothelial Protein C Receptor Shedding In Vitro and In Vivo" @default.
- W1831487034 cites W1541952400 @default.
- W1831487034 cites W1570103822 @default.
- W1831487034 cites W1964415576 @default.
- W1831487034 cites W1974680615 @default.
- W1831487034 cites W1981132274 @default.
- W1831487034 cites W1991087729 @default.
- W1831487034 cites W1993601122 @default.
- W1831487034 cites W2016903934 @default.
- W1831487034 cites W2019922242 @default.
- W1831487034 cites W2020363094 @default.
- W1831487034 cites W2042821764 @default.
- W1831487034 cites W2048729530 @default.
- W1831487034 cites W2050633484 @default.
- W1831487034 cites W2052733114 @default.
- W1831487034 cites W2082987676 @default.
- W1831487034 cites W2086733600 @default.
- W1831487034 cites W2108664084 @default.
- W1831487034 cites W2138817077 @default.
- W1831487034 cites W2148127512 @default.
- W1831487034 cites W2151629789 @default.
- W1831487034 cites W2160369507 @default.
- W1831487034 cites W2171634238 @default.
- W1831487034 cites W2214759602 @default.
- W1831487034 cites W2783888699 @default.
- W1831487034 cites W307794551 @default.
- W1831487034 doi "https://doi.org/10.5352/jls.2013.23.5.650" @default.
- W1831487034 hasPublicationYear "2013" @default.
- W1831487034 type Work @default.
- W1831487034 sameAs 1831487034 @default.
- W1831487034 citedByCount "0" @default.
- W1831487034 crossrefType "journal-article" @default.
- W1831487034 hasAuthorship W1831487034A5005439728 @default.
- W1831487034 hasAuthorship W1831487034A5007125221 @default.
- W1831487034 hasAuthorship W1831487034A5040436938 @default.
- W1831487034 hasAuthorship W1831487034A5042460370 @default.
- W1831487034 hasBestOaLocation W18314870341 @default.
- W1831487034 hasConcept C17991360 @default.
- W1831487034 hasConcept C203014093 @default.
- W1831487034 hasConcept C2776816377 @default.
- W1831487034 hasConcept C2777292125 @default.
- W1831487034 hasConcept C86803240 @default.
- W1831487034 hasConcept C89560881 @default.
- W1831487034 hasConceptScore W1831487034C17991360 @default.
- W1831487034 hasConceptScore W1831487034C203014093 @default.
- W1831487034 hasConceptScore W1831487034C2776816377 @default.
- W1831487034 hasConceptScore W1831487034C2777292125 @default.
- W1831487034 hasConceptScore W1831487034C86803240 @default.
- W1831487034 hasConceptScore W1831487034C89560881 @default.
- W1831487034 hasIssue "5" @default.
- W1831487034 hasLocation W18314870341 @default.
- W1831487034 hasOpenAccess W1831487034 @default.
- W1831487034 hasPrimaryLocation W18314870341 @default.
- W1831487034 hasRelatedWork W1979472130 @default.
- W1831487034 hasRelatedWork W1988906407 @default.
- W1831487034 hasRelatedWork W1994050787 @default.
- W1831487034 hasRelatedWork W2029799529 @default.
- W1831487034 hasRelatedWork W2111945182 @default.
- W1831487034 hasRelatedWork W2154748714 @default.
- W1831487034 hasRelatedWork W2248876427 @default.
- W1831487034 hasRelatedWork W2398878426 @default.
- W1831487034 hasRelatedWork W2417464427 @default.
- W1831487034 hasRelatedWork W2469796471 @default.
- W1831487034 hasVolume "23" @default.
- W1831487034 isParatext "false" @default.
- W1831487034 isRetracted "false" @default.
- W1831487034 magId "1831487034" @default.
- W1831487034 workType "article" @default.