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- W183169141 abstract "In preclinical studies first published in 1989 by Giovanella and colleagues, 9-aminocamptothecin (9-AC) demonstrated highly promising antitumor activity against human colorectal cancer xenografts (). This led to an extensive drug development program for 9-AC initially under the guidance of the National Cancer Institute, and later in cooperation with pharmaceutical industry sponsors. However, despite this impressive preclinical activity, 9-AC has not demonstrated clinically useful antitumor activity to date. Thus, in contrast to its more successful brethren, irinotecan and topotecan, 9-AC is no longer under active clinical development. Nonetheless, testing of other novel and new camptothecin derivatives remains an active area of pharmacological research. Thus a careful review of the early clinical and pharmacological trials of 9-AC may help us to understand why 9-AC has not shown more meaningful antitumor activity and may also provide important lessons for the future drug development of novel camptothecins and other topoisomerase I (TOP-I) targeting agents." @default.
- W183169141 created "2016-06-24" @default.
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- W183169141 date "2005-01-01" @default.
- W183169141 modified "2023-10-14" @default.
- W183169141 title "Clinical Experience With 9-Aminocamptothecin" @default.
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- W183169141 doi "https://doi.org/10.1385/1-59259-866-8:193" @default.
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