Matches in SemOpenAlex for { <https://semopenalex.org/work/W1831738118> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1831738118 endingPage "409" @default.
- W1831738118 startingPage "402" @default.
- W1831738118 abstract "Next generation sequencing holds great promise for detecting rare variants underlying complex human traits. Due to their extremely low allele frequencies, the normality approximation for a proportion no longer works well. The Fisher’s exact method appears to be suitable but it is conservative. We investigate the utility of various variance-stabilising transformations in single marker association analysis on rare variants. Unlike a proportion itself, the variance of the transformed proportions no longer depends on the proportion, making application of such transformations to rare variant association analysis extremely appealing. Simulation studies demonstrate that tests based on such transformations are more powerful than the Fisher’s exact test while controlling for type I error rate. Based on theoretical considerations and results from simulation studies, we recommend the test based on the Anscombe transformation over tests with other transformations." @default.
- W1831738118 created "2016-06-24" @default.
- W1831738118 creator A5066474989 @default.
- W1831738118 creator A5073531557 @default.
- W1831738118 date "2012-06-25" @default.
- W1831738118 modified "2023-10-18" @default.
- W1831738118 title "Statistical Tests for Detecting Rare Variants Using Variance-Stabilising Transformations" @default.
- W1831738118 cites W1965331138 @default.
- W1831738118 cites W1981012086 @default.
- W1831738118 cites W2005848760 @default.
- W1831738118 cites W2007733142 @default.
- W1831738118 cites W2021262032 @default.
- W1831738118 cites W2041953582 @default.
- W1831738118 cites W2049020839 @default.
- W1831738118 cites W2053725906 @default.
- W1831738118 cites W2058148991 @default.
- W1831738118 cites W2092923243 @default.
- W1831738118 cites W2100882140 @default.
- W1831738118 cites W2104776392 @default.
- W1831738118 cites W2160435411 @default.
- W1831738118 cites W2164143816 @default.
- W1831738118 doi "https://doi.org/10.1111/j.1469-1809.2012.00718.x" @default.
- W1831738118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3418475" @default.
- W1831738118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22724536" @default.
- W1831738118 hasPublicationYear "2012" @default.
- W1831738118 type Work @default.
- W1831738118 sameAs 1831738118 @default.
- W1831738118 citedByCount "7" @default.
- W1831738118 countsByYear W18317381182013 @default.
- W1831738118 countsByYear W18317381182018 @default.
- W1831738118 countsByYear W18317381182021 @default.
- W1831738118 countsByYear W18317381182023 @default.
- W1831738118 crossrefType "journal-article" @default.
- W1831738118 hasAuthorship W1831738118A5066474989 @default.
- W1831738118 hasAuthorship W1831738118A5073531557 @default.
- W1831738118 hasBestOaLocation W18317381181 @default.
- W1831738118 hasConcept C104317684 @default.
- W1831738118 hasConcept C105795698 @default.
- W1831738118 hasConcept C11413529 @default.
- W1831738118 hasConcept C121955636 @default.
- W1831738118 hasConcept C144133560 @default.
- W1831738118 hasConcept C183905921 @default.
- W1831738118 hasConcept C191093355 @default.
- W1831738118 hasConcept C196083921 @default.
- W1831738118 hasConcept C204241405 @default.
- W1831738118 hasConcept C2776157432 @default.
- W1831738118 hasConcept C3018076075 @default.
- W1831738118 hasConcept C33923547 @default.
- W1831738118 hasConcept C40696583 @default.
- W1831738118 hasConcept C41008148 @default.
- W1831738118 hasConcept C54355233 @default.
- W1831738118 hasConcept C70721500 @default.
- W1831738118 hasConcept C86803240 @default.
- W1831738118 hasConcept C87007009 @default.
- W1831738118 hasConcept C99476002 @default.
- W1831738118 hasConceptScore W1831738118C104317684 @default.
- W1831738118 hasConceptScore W1831738118C105795698 @default.
- W1831738118 hasConceptScore W1831738118C11413529 @default.
- W1831738118 hasConceptScore W1831738118C121955636 @default.
- W1831738118 hasConceptScore W1831738118C144133560 @default.
- W1831738118 hasConceptScore W1831738118C183905921 @default.
- W1831738118 hasConceptScore W1831738118C191093355 @default.
- W1831738118 hasConceptScore W1831738118C196083921 @default.
- W1831738118 hasConceptScore W1831738118C204241405 @default.
- W1831738118 hasConceptScore W1831738118C2776157432 @default.
- W1831738118 hasConceptScore W1831738118C3018076075 @default.
- W1831738118 hasConceptScore W1831738118C33923547 @default.
- W1831738118 hasConceptScore W1831738118C40696583 @default.
- W1831738118 hasConceptScore W1831738118C41008148 @default.
- W1831738118 hasConceptScore W1831738118C54355233 @default.
- W1831738118 hasConceptScore W1831738118C70721500 @default.
- W1831738118 hasConceptScore W1831738118C86803240 @default.
- W1831738118 hasConceptScore W1831738118C87007009 @default.
- W1831738118 hasConceptScore W1831738118C99476002 @default.
- W1831738118 hasIssue "5" @default.
- W1831738118 hasLocation W18317381181 @default.
- W1831738118 hasLocation W18317381182 @default.
- W1831738118 hasLocation W18317381183 @default.
- W1831738118 hasLocation W18317381184 @default.
- W1831738118 hasOpenAccess W1831738118 @default.
- W1831738118 hasPrimaryLocation W18317381181 @default.
- W1831738118 hasRelatedWork W1831738118 @default.
- W1831738118 hasRelatedWork W1964512297 @default.
- W1831738118 hasRelatedWork W2148028649 @default.
- W1831738118 hasRelatedWork W2169910187 @default.
- W1831738118 hasRelatedWork W2246545666 @default.
- W1831738118 hasRelatedWork W3042338052 @default.
- W1831738118 hasRelatedWork W3122922987 @default.
- W1831738118 hasRelatedWork W3177851450 @default.
- W1831738118 hasRelatedWork W4318026423 @default.
- W1831738118 hasRelatedWork W2316793656 @default.
- W1831738118 hasVolume "76" @default.
- W1831738118 isParatext "false" @default.
- W1831738118 isRetracted "false" @default.
- W1831738118 magId "1831738118" @default.
- W1831738118 workType "article" @default.