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- W1832133070 endingPage "1819" @default.
- W1832133070 startingPage "1803" @default.
- W1832133070 abstract "Interferon-β (IFNβ) is well established as a disease-modifying treatment for patients with multiple sclerosis. Several preparations of the biopharmaceutical are available differing in protein structure, formulation, dose as well as frequency and route of administration. Recently, a pegylated form of IFNβ has been marketed.Following a PubMed database search, we provide an overview of what is presently known about the pharmacokinetics (PK) of IFNβ including its absorption, distribution, metabolism and elimination. Also, we discuss the association with clinically relevant issues such as treatment efficacy, adverse events and anti-drug antibodies.IFNβ has a bioavailability of ∼ 30% after subcutaneous or intramuscular administration, shows peak serum concentrations within several hours, has a half-life of < 1 day and is eliminated by a renal and hepatic pathway. PK parameters do not substantially differ between the types of IFNβ and routes of administration; only pegylation of IFNβ results in substantially increased and prolonged PK. Although no clinical dose-effect relationship could be established, there is an association of IFNβ dose with magnetic resonance imaging outcome parameters. Furthermore, there is an association of IFNβ serum levels with the occurrence of adverse events and anti-drug antibodies." @default.
- W1832133070 created "2016-06-24" @default.
- W1832133070 creator A5014894550 @default.
- W1832133070 creator A5039495989 @default.
- W1832133070 creator A5056983959 @default.
- W1832133070 date "2015-09-30" @default.
- W1832133070 modified "2023-09-29" @default.
- W1832133070 title "Pharmacokinetic considerations in the treatment of multiple sclerosis with interferon-β" @default.
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