FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1832248617> ?p ?o ?g. }

• W1832248617 abstract "The palatine tonsils have a pivotal role in immunological detection of airborne and ingested antigens like bacteria and viruses. They have recently been demonstrated to express Toll-like receptors (TLRs), known to recognize molecular structures on such microbes and activate innate immune responses. Their activation might also provide a link between innate and adaptive immunity. In the present study, the expression profile of TLR1-TLR10 was characterized in human tonsil T cells, focusing on differences between subsets of CD4+ T helper (Th) cells and CD8+ cytotoxic T lymphocytes (CTL). The study was also designed to compare the TLR expression in T cells from patients with recurrent tonsillitis and tonsillar hyperplasia.Tonsils were obtained from children undergoing tonsillectomy, and classified according to the clinical diagnoses and the outcome of tonsillar core culture tests. Two groups were defined; recurrently infected tonsils and hyperplastic tonsils that served as controls. Subsets of T cells were isolated using magnetic beads. The expression of TLR transcripts in purified cells was assessed using quantitative real-time RT-PCR. The corresponding protein expression was investigated using flow cytometry and immunohistochemistry.T cells expressed a broad repertoire of TLRs, in which TLR1, TLR2, TLR5, TLR9 and TLR10 predominated. Also, a differential expression of TLRs in CD4+ and CD8+ T cells was obtained. TLR1 and TLR9 mRNA was expressed to a greater extent in CD4+ cells, whereas expression of TLR3 mRNA and protein and TLR4 protein was higher in CD8+ cells. CD8+ cells from infected tonsils expressed higher levels of TLR2, TLR3 and TLR5 compared to control. In contrast, CD4+ cells exhibited a down-regulated TLR9 as a consequence of infection.The present study demonstrates the presence of a broad repertoire of TLRs in T cells, a differential expression in CD4+ and CD8+ cells, along with infection-dependent alterations in TLR expression. Collectively, these results support the idea that TLRs are of importance to adaptive immune cells. It might be that TLRs have a direct role in adaptive immune reactions against infections. Thus, further functional studies of the relevance of TLR stimulation on T cells will be of importance." @default.
• W1832248617 created "2016-06-24" @default.
• W1832248617 creator A5003694914 @default.
• W1832248617 creator A5008754572 @default.
• W1832248617 creator A5035165090 @default.
• W1832248617 date "2006-02-27" @default.
• W1832248617 modified "2023-10-16" @default.
• W1832248617 title "Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis" @default.
• W1832248617 cites W1008433122 @default.
• W1832248617 cites W146736027 @default.
• W1832248617 cites W1510714540 @default.
• W1832248617 cites W1543108498 @default.
• W1832248617 cites W1661544713 @default.
• W1832248617 cites W1676806089 @default.
• W1832248617 cites W1717079841 @default.
• W1832248617 cites W1770811198 @default.
• W1832248617 cites W1808849435 @default.
• W1832248617 cites W1934712179 @default.
• W1832248617 cites W1946226823 @default.
• W1832248617 cites W1950448919 @default.
• W1832248617 cites W1965840687 @default.
• W1832248617 cites W1969072247 @default.
• W1832248617 cites W1976300852 @default.
• W1832248617 cites W1982143129 @default.
• W1832248617 cites W1983882689 @default.
• W1832248617 cites W1985990657 @default.
• W1832248617 cites W1988338839 @default.
• W1832248617 cites W1991236592 @default.
• W1832248617 cites W1998224639 @default.
• W1832248617 cites W2004773897 @default.
• W1832248617 cites W2026975595 @default.
• W1832248617 cites W2030689421 @default.
• W1832248617 cites W2040921284 @default.
• W1832248617 cites W2041912408 @default.
• W1832248617 cites W2046964116 @default.
• W1832248617 cites W2054493318 @default.
• W1832248617 cites W2057121293 @default.
• W1832248617 cites W2065638217 @default.
• W1832248617 cites W2074121683 @default.
• W1832248617 cites W2082865800 @default.
• W1832248617 cites W2088708811 @default.
• W1832248617 cites W2090640877 @default.
• W1832248617 cites W2110834028 @default.
• W1832248617 cites W2114637517 @default.
• W1832248617 cites W2135389367 @default.
• W1832248617 cites W2137234814 @default.
• W1832248617 cites W2143112023 @default.
• W1832248617 cites W2151777859 @default.
• W1832248617 cites W2165871546 @default.
• W1832248617 cites W4313422262 @default.
• W1832248617 doi "https://doi.org/10.1186/1465-9921-7-36" @default.
• W1832248617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1481585" @default.
• W1832248617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16504163" @default.
• W1832248617 hasPublicationYear "2006" @default.
• W1832248617 type Work @default.
• W1832248617 sameAs 1832248617 @default.
• W1832248617 citedByCount "84" @default.
• W1832248617 countsByYear W18322486172012 @default.
• W1832248617 countsByYear W18322486172013 @default.
• W1832248617 countsByYear W18322486172014 @default.
• W1832248617 countsByYear W18322486172015 @default.
• W1832248617 countsByYear W18322486172016 @default.
• W1832248617 countsByYear W18322486172017 @default.
• W1832248617 countsByYear W18322486172018 @default.
• W1832248617 countsByYear W18322486172020 @default.
• W1832248617 countsByYear W18322486172021 @default.
• W1832248617 countsByYear W18322486172022 @default.
• W1832248617 crossrefType "journal-article" @default.
• W1832248617 hasAuthorship W1832248617A5003694914 @default.
• W1832248617 hasAuthorship W1832248617A5008754572 @default.
• W1832248617 hasAuthorship W1832248617A5035165090 @default.
• W1832248617 hasBestOaLocation W18322486171 @default.
• W1832248617 hasConcept C104317684 @default.
• W1832248617 hasConcept C136449434 @default.
• W1832248617 hasConcept C147483822 @default.
• W1832248617 hasConcept C150194340 @default.
• W1832248617 hasConcept C154317977 @default.
• W1832248617 hasConcept C167672396 @default.
• W1832248617 hasConcept C190727270 @default.
• W1832248617 hasConcept C193419808 @default.
• W1832248617 hasConcept C202751555 @default.
• W1832248617 hasConcept C203014093 @default.
• W1832248617 hasConcept C2776709828 @default.
• W1832248617 hasConcept C2777338127 @default.
• W1832248617 hasConcept C2778420691 @default.
• W1832248617 hasConcept C2779138994 @default.
• W1832248617 hasConcept C2779419017 @default.
• W1832248617 hasConcept C2781236682 @default.
• W1832248617 hasConcept C55493867 @default.
• W1832248617 hasConcept C86803240 @default.
• W1832248617 hasConcept C8891405 @default.
• W1832248617 hasConceptScore W1832248617C104317684 @default.
• W1832248617 hasConceptScore W1832248617C136449434 @default.
• W1832248617 hasConceptScore W1832248617C147483822 @default.
• W1832248617 hasConceptScore W1832248617C150194340 @default.
• W1832248617 hasConceptScore W1832248617C154317977 @default.
• W1832248617 hasConceptScore W1832248617C167672396 @default.
• W1832248617 hasConceptScore W1832248617C190727270 @default.
• W1832248617 hasConceptScore W1832248617C193419808 @default.
• W1832248617 hasConceptScore W1832248617C202751555 @default.

• next