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• W1832270009 startingPage "99" @default.
• W1832270009 abstract "ABSTRACT The multinucleated macroschizont stage of the proto-zoon Theileria annulata is an intracellular parasite of bovine leukocytes. The parasite induces the host cell to proliferate, and divides in synchrony with the immortalised host cell. Differentiation to the next stage occurs within the host cell culminating in the release of merozoites and destruction of the leukocyte. In this study clones of Theileria annulata macroschizont-infected cell lines were isolated by limiting dilution and tested for differentiation to the merozoite stage (mero-gony). Two cloned cell lines underwent differentiation with enhanced efficiency, while two others were of lower efficiency. Quantification was carried out using monoclonal antibodies, which showed that over 90% of the cells in an enhanced cloned cell line could be induced to differentiate. By carrying out induction at 41°C for limited periods of time followed by culture at 37°C evidence was obtained that differentiation to the merozoite is a two-step process: a preliminary reversible phase, followed by a second irreversible phase of differentiation. Analysis of the nuclear number of the macroschizont and the growth rate of the cloned cell lines showed that the ability to differentiate was associated with an increase in nuclear number (size) of the macroschizont, generated by a disruption in the synchrony between parasite growth and host cell division. We believe that these results reveal a relationship between a reduction in parasite division and differentiation, and that there are similarities between stage differentiation in parasites and cellular differentiation in higher eukaryotes." @default.
• W1832270009 created "2016-06-24" @default.
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• W1832270009 date "1992-01-01" @default.
• W1832270009 modified "2023-10-09" @default.
• W1832270009 title "Disruption of synchrony between parasite growth and host cell division is a determinant of differentiation to the merozoite in <i>Theileria annulata</i>" @default.
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• W1832270009 doi "https://doi.org/10.1242/jcs.101.1.99" @default.
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