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• W1832285227 endingPage "2242" @default.
• W1832285227 startingPage "2221" @default.
• W1832285227 abstract "Oligonucleotide therapeutics have the potential to become a third pillar of drug development after small molecules and protein therapeutics. However, the three approved oligonucleotide drugs over the past 17 years have not proven to be highly successful in a commercial sense. These trailblazer drugs have nonetheless laid the foundations for entire classes of drug candidates to follow. This review will examine further advances in chemistry that are earlier in the pipeline of oligonucleotide drug candidates. Finally, we consider the possible effect of delivery systems that may provide extra footholds to improve the potency and specificity of oligonucleotide drugs. Our overview focuses on strategies to imbue antisense oligonucleotides with more drug-like properties and their applicability to other nucleic acid therapeutics." @default.
• W1832285227 created "2016-06-24" @default.
• W1832285227 creator A5027544487 @default.
• W1832285227 creator A5049957906 @default.
• W1832285227 date "2015-10-01" @default.
• W1832285227 modified "2023-10-02" @default.
• W1832285227 title "Oligonucleotide therapeutics: chemistry, delivery and clinical progress" @default.
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