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- W1832493108 abstract "We discuss the need for multidimensional stochastic models of physiological processes to describe the evolving risk of chronic disease over a lifetime. Modifications of that type of model needed to describe different types of risk factor and health effects collected in different longitudinal studies are described. How health processes are “captured” in different longitudinal study designs is discussed, as is the description of the intra-individual dynamics of degenerative processes. The concept of hormesis is introduced as are more standard types of hazard models (Weibull and Gompertz) drawn from reliability theory. Measurements that may be made in molecular epidemiological studies are discussed and issues that they raise for statistical modeling of disease processes reviewed. Methods for analyzing the genetic contributions to chronic disease risks are presented and discussed.Keywords:hazard function;diffusion process;carcinogenesis;cardiovascular disease;risk factors;hormesis;genetics;and molecular epidemiology" @default.
- W1832493108 created "2016-06-24" @default.
- W1832493108 creator A5009263556 @default.
- W1832493108 date "2014-09-29" @default.
- W1832493108 modified "2023-09-24" @default.
- W1832493108 title "Chronic Disease Models" @default.
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- W1832493108 doi "https://doi.org/10.1002/9781118445112.stat05265" @default.
- W1832493108 hasPublicationYear "2014" @default.
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