Matches in SemOpenAlex for { <https://semopenalex.org/work/W1832497257> ?p ?o ?g. }
- W1832497257 endingPage "e0128676" @default.
- W1832497257 startingPage "e0128676" @default.
- W1832497257 abstract "Inflammation and immune response profoundly influence metabolic syndrome and fatty acid metabolism. To analyze influence of systemic inflammatory response to metabolic syndrome, we inoculated an attenuated vaccine strain of Mycobacterium bovis Bacillus Calmette-Guérin (BCG) into leptin-deficient ob/ob mice. BCG administration significantly decreased epididymal white adipose tissue weight, serum insulin levels, and a homeostasis model assessment of insulin resistance. Serum high molecular weight (HMW) adiponectin level and HMW/total adiponectin ratio of the BCG treated mice were significantly higher than those of control mice. Hepatic triglyceride accumulation and macrovesicular steatosis were markedly alleviated, and the enzymatic activities and mRNA levels of lipogenic-related genes in liver were significantly decreased in the BCG injected mice. We also exposed human hepatocellular carcinoma HepG2 cells to high levels of palmitate, which enhanced endoplasmic reticulum stress-related gene expression and impaired insulin-stimulated Akt phosphorylation (Ser473). BCG treatment ameliorated both of these detrimental events. The present study therefore suggested that BCG administration suppressed development of nonalcoholic fatty liver disease, at least partly, by alleviating fatty acid-induced insulin resistance in the liver." @default.
- W1832497257 created "2016-06-24" @default.
- W1832497257 creator A5017554585 @default.
- W1832497257 creator A5028763058 @default.
- W1832497257 creator A5032549835 @default.
- W1832497257 date "2015-06-03" @default.
- W1832497257 modified "2023-10-14" @default.
- W1832497257 title "Intravenous Mycobacterium Bovis Bacillus Calmette-Guérin Ameliorates Nonalcoholic Fatty Liver Disease in Obese, Diabetic ob/ob Mice" @default.
- W1832497257 cites W1523155649 @default.
- W1832497257 cites W1524321743 @default.
- W1832497257 cites W1978734768 @default.
- W1832497257 cites W1981093904 @default.
- W1832497257 cites W1990530689 @default.
- W1832497257 cites W1996139081 @default.
- W1832497257 cites W1999666298 @default.
- W1832497257 cites W2003021612 @default.
- W1832497257 cites W2005428158 @default.
- W1832497257 cites W2007078899 @default.
- W1832497257 cites W2010425790 @default.
- W1832497257 cites W2012293375 @default.
- W1832497257 cites W2022146147 @default.
- W1832497257 cites W2022380869 @default.
- W1832497257 cites W2024661492 @default.
- W1832497257 cites W2027575368 @default.
- W1832497257 cites W2029334399 @default.
- W1832497257 cites W2041802340 @default.
- W1832497257 cites W2052034388 @default.
- W1832497257 cites W2053500970 @default.
- W1832497257 cites W2054958229 @default.
- W1832497257 cites W2054990533 @default.
- W1832497257 cites W2059105129 @default.
- W1832497257 cites W2060890398 @default.
- W1832497257 cites W2064953244 @default.
- W1832497257 cites W2065791817 @default.
- W1832497257 cites W2067925937 @default.
- W1832497257 cites W2070823425 @default.
- W1832497257 cites W2080672046 @default.
- W1832497257 cites W2087822868 @default.
- W1832497257 cites W2088248157 @default.
- W1832497257 cites W2093804178 @default.
- W1832497257 cites W2094051977 @default.
- W1832497257 cites W2100117556 @default.
- W1832497257 cites W2100856416 @default.
- W1832497257 cites W2108246274 @default.
- W1832497257 cites W2113562019 @default.
- W1832497257 cites W2113653640 @default.
- W1832497257 cites W2116291006 @default.
- W1832497257 cites W2118338384 @default.
- W1832497257 cites W2120496938 @default.
- W1832497257 cites W2120623114 @default.
- W1832497257 cites W2124464501 @default.
- W1832497257 cites W2124620553 @default.
- W1832497257 cites W2126827988 @default.
- W1832497257 cites W2127906377 @default.
- W1832497257 cites W2130046741 @default.
- W1832497257 cites W2130078845 @default.
- W1832497257 cites W2131698535 @default.
- W1832497257 cites W2138723029 @default.
- W1832497257 cites W2146204398 @default.
- W1832497257 cites W2146845495 @default.
- W1832497257 cites W2151073893 @default.
- W1832497257 cites W2160832007 @default.
- W1832497257 cites W2162614886 @default.
- W1832497257 cites W2166928892 @default.
- W1832497257 cites W2168526937 @default.
- W1832497257 cites W4237772238 @default.
- W1832497257 cites W4255882557 @default.
- W1832497257 cites W1964184380 @default.
- W1832497257 doi "https://doi.org/10.1371/journal.pone.0128676" @default.
- W1832497257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4454685" @default.
- W1832497257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26039731" @default.
- W1832497257 hasPublicationYear "2015" @default.
- W1832497257 type Work @default.
- W1832497257 sameAs 1832497257 @default.
- W1832497257 citedByCount "8" @default.
- W1832497257 countsByYear W18324972572017 @default.
- W1832497257 countsByYear W18324972572019 @default.
- W1832497257 countsByYear W18324972572020 @default.
- W1832497257 countsByYear W18324972572021 @default.
- W1832497257 countsByYear W18324972572022 @default.
- W1832497257 countsByYear W18324972572023 @default.
- W1832497257 crossrefType "journal-article" @default.
- W1832497257 hasAuthorship W1832497257A5017554585 @default.
- W1832497257 hasAuthorship W1832497257A5028763058 @default.
- W1832497257 hasAuthorship W1832497257A5032549835 @default.
- W1832497257 hasBestOaLocation W18324972571 @default.
- W1832497257 hasConcept C126322002 @default.
- W1832497257 hasConcept C134018914 @default.
- W1832497257 hasConcept C171089720 @default.
- W1832497257 hasConcept C2776175330 @default.
- W1832497257 hasConcept C2776782570 @default.
- W1832497257 hasConcept C2776954865 @default.
- W1832497257 hasConcept C2777391703 @default.
- W1832497257 hasConcept C2778772119 @default.
- W1832497257 hasConcept C2779134260 @default.
- W1832497257 hasConcept C2779306644 @default.
- W1832497257 hasConcept C2780578515 @default.
- W1832497257 hasConcept C555293320 @default.