FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1832511462> ?p ?o ?g. }

• W1832511462 endingPage "4687" @default.
• W1832511462 startingPage "4679" @default.
• W1832511462 abstract "Stimulation of cells of the macrophage lineage is a crucial step in the sensing of yeasts by the immune system. Glycans present in both Candida albicans and Saccharomyces cerevisiae cell walls have been shown to act as ligands for different receptors leading to different stimulating pathways, some of which need receptor co-involvement. However, among these ligand-receptor couples, none has been shown to discriminate the pathogenic yeast C. albicans. We explored the role of galectin-3, which binds C. albicans beta-1,2 mannosides. These glycans are specifically and prominently expressed at the surface of C. albicans but not on S. cerevisiae. Using a mouse cell line and galectin-3-deleted cells from knockout mice, we demonstrated a specific enhancement of the cellular response to C. albicans compared with S. cerevisiae, which depended on galectin-3 expression. However, galectin-3 was not required for recognition and endocytosis of yeasts. In contrast, using PMA-induced differentiated THP-1, we observed that the presence of TLR2 was required for efficient uptake and endocytosis of both C. albicans and S. cerevisiae. TLR2 and galectin-3, which are expressed at the level of phagosomes containing C. albicans, were shown to be associated in differentiated macrophages after incubation with this sole species. These data suggest that macrophages differently sense C. albicans and S. cerevisiae through a mechanism involving TLR2 and galectin-3, which probably associate for binding of ligands expressing beta-1,2 mannosides specific to the C. albicans cell wall surface." @default.
• W1832511462 created "2016-06-24" @default.
• W1832511462 creator A5012702039 @default.
• W1832511462 creator A5014012945 @default.
• W1832511462 creator A5021798065 @default.
• W1832511462 creator A5034634907 @default.
• W1832511462 creator A5042491473 @default.
• W1832511462 creator A5052994779 @default.
• W1832511462 creator A5067398092 @default.
• W1832511462 creator A5088733543 @default.
• W1832511462 date "2006-10-01" @default.
• W1832511462 modified "2023-10-17" @default.
• W1832511462 title "Specific Recognition of <i>Candida albicans</i> by Macrophages Requires Galectin-3 to Discriminate <i>Saccharomyces cerevisiae</i> and Needs Association with TLR2 for Signaling" @default.
• W1832511462 cites W1562117121 @default.
• W1832511462 cites W1635143728 @default.
• W1832511462 cites W1965897811 @default.
• W1832511462 cites W1967678185 @default.
• W1832511462 cites W1978676714 @default.
• W1832511462 cites W1979487024 @default.
• W1832511462 cites W1980140633 @default.
• W1832511462 cites W1982942596 @default.
• W1832511462 cites W1987522174 @default.
• W1832511462 cites W1992006091 @default.
• W1832511462 cites W1992078470 @default.
• W1832511462 cites W1995441274 @default.
• W1832511462 cites W2003099813 @default.
• W1832511462 cites W2009943989 @default.
• W1832511462 cites W2017975787 @default.
• W1832511462 cites W2021669132 @default.
• W1832511462 cites W2027589717 @default.
• W1832511462 cites W2029622398 @default.
• W1832511462 cites W2029987169 @default.
• W1832511462 cites W2035921968 @default.
• W1832511462 cites W2047067218 @default.
• W1832511462 cites W2048265787 @default.
• W1832511462 cites W2051053703 @default.
• W1832511462 cites W2058049578 @default.
• W1832511462 cites W2059037690 @default.
• W1832511462 cites W2072237621 @default.
• W1832511462 cites W2074233079 @default.
• W1832511462 cites W2079097785 @default.
• W1832511462 cites W2089975782 @default.
• W1832511462 cites W2098084836 @default.
• W1832511462 cites W2099845332 @default.
• W1832511462 cites W2100343814 @default.
• W1832511462 cites W2100585044 @default.
• W1832511462 cites W2102788118 @default.
• W1832511462 cites W2102867745 @default.
• W1832511462 cites W2104460754 @default.
• W1832511462 cites W2105170573 @default.
• W1832511462 cites W2105670393 @default.
• W1832511462 cites W2107531246 @default.
• W1832511462 cites W2124759169 @default.
• W1832511462 cites W2126924404 @default.
• W1832511462 cites W2127987168 @default.
• W1832511462 cites W2128128380 @default.
• W1832511462 cites W2129715917 @default.
• W1832511462 cites W2137173669 @default.
• W1832511462 cites W2143498880 @default.
• W1832511462 cites W2147969002 @default.
• W1832511462 cites W2154820152 @default.
• W1832511462 cites W2157339124 @default.
• W1832511462 cites W2169818746 @default.
• W1832511462 cites W2263576957 @default.
• W1832511462 cites W2411891289 @default.
• W1832511462 cites W4252859460 @default.
• W1832511462 doi "https://doi.org/10.4049/jimmunol.177.7.4679" @default.
• W1832511462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16982907" @default.
• W1832511462 hasPublicationYear "2006" @default.
• W1832511462 type Work @default.
• W1832511462 sameAs 1832511462 @default.
• W1832511462 citedByCount "208" @default.
• W1832511462 countsByYear W18325114622012 @default.
• W1832511462 countsByYear W18325114622013 @default.
• W1832511462 countsByYear W18325114622014 @default.
• W1832511462 countsByYear W18325114622015 @default.
• W1832511462 countsByYear W18325114622016 @default.
• W1832511462 countsByYear W18325114622017 @default.
• W1832511462 countsByYear W18325114622018 @default.
• W1832511462 countsByYear W18325114622019 @default.
• W1832511462 countsByYear W18325114622020 @default.
• W1832511462 countsByYear W18325114622021 @default.
• W1832511462 countsByYear W18325114622022 @default.
• W1832511462 countsByYear W18325114622023 @default.
• W1832511462 crossrefType "journal-article" @default.
• W1832511462 hasAuthorship W1832511462A5012702039 @default.
• W1832511462 hasAuthorship W1832511462A5014012945 @default.
• W1832511462 hasAuthorship W1832511462A5021798065 @default.
• W1832511462 hasAuthorship W1832511462A5034634907 @default.
• W1832511462 hasAuthorship W1832511462A5042491473 @default.
• W1832511462 hasAuthorship W1832511462A5052994779 @default.
• W1832511462 hasAuthorship W1832511462A5067398092 @default.
• W1832511462 hasAuthorship W1832511462A5088733543 @default.
• W1832511462 hasBestOaLocation W18325114621 @default.
• W1832511462 hasConcept C136449434 @default.
• W1832511462 hasConcept C145081991 @default.
• W1832511462 hasConcept C156293190 @default.
• W1832511462 hasConcept C160448771 @default.

• next