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- W1832882893 abstract "Abstract The proteins encoded by two groups of conserved genes, the Polycomb and trithorax groups, have been proposed to maintain, at the level of chromatin structure, the expression pattern of homeotic genes during Drosophila development. To identify new members of the trithorax group, we screened a collection of deficiencies for intergenic noncomplementation with a mutation in ash1, a trithorax group gene. Five of the noncomplementing deletions uncover genes previously classified as members of the Polycomb group. This evidence suggests that there are actually three groups of genes that maintain the expression pattern of homeotic genes during Drosophila development. The products of the third group appear to be required to maintain chromatin in both transcriptionally inactive and active states. Six of the noncomplementing deficiencies uncover previously unidentified trithorax group genes. One of these deficiencies removes 25D2-3 to 26B2-5. Within this region, there are two, allelic, lethal P-insertion mutations that identify one of these new trithorax group genes. The gene has been called little imaginal discs based on the phenotype of mutant larvae. The protein encoded by the little imaginal discs gene is the Drosophila homologue of human retinoblastoma binding protein 2." @default.
- W1832882893 created "2016-06-24" @default.
- W1832882893 creator A5014808968 @default.
- W1832882893 creator A5020463389 @default.
- W1832882893 creator A5088912654 @default.
- W1832882893 date "2000-10-01" @default.
- W1832882893 modified "2023-10-03" @default.
- W1832882893 title "A Screen for New Trithorax Group Genes Identified <i>little imaginal discs</i>, the <i>Drosophila melanogaster</i> Homologue of Human Retinoblastoma Binding Protein 2" @default.
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