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- W1832920476 endingPage "683" @default.
- W1832920476 startingPage "665" @default.
- W1832920476 abstract "Maintenance of biological functions under negative energy balance depends on mobilization of storage lipids and carbohydrates in animals. In mammals, glucagon and glucocorticoid signaling mobilizes energy reserves, whereas adipokinetic hormones (AKHs) play a homologous role in insects. Numerous studies based on AKH injections and correlative studies in a broad range of insect species established the view that AKH acts as master regulator of energy mobilization during development, reproduction, and stress. In contrast to AKH, the second peptide, which is processed from the Akh encoded prohormone [termed adipokinetic hormone precursor-related peptide (APRP)] is functionally orphan. APRP is discussed as ecdysiotropic hormone or as scaffold peptide during AKH prohormone processing. However, as in the case of AKH, final evidence for APRP functions requires genetic mutant analysis. Here we employed CRISPR/Cas9-mediated genome engineering to create AKH and AKH plus APRP-specific mutants in the model insect Drosophila melanogaster. Lack of APRP did not affect any of the tested steroid-dependent processes. Similarly, Drosophila AKH signaling is dispensable for ontogenesis, locomotion, oogenesis, and homeostasis of lipid or carbohydrate storage until up to the end of metamorphosis. During adulthood, however, AKH regulates body fat content and the hemolymph sugar level as well as nutritional and oxidative stress responses. Finally, we provide evidence for a negative autoregulatory loop in Akh gene regulation." @default.
- W1832920476 created "2016-06-24" @default.
- W1832920476 creator A5009402436 @default.
- W1832920476 creator A5010896400 @default.
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- W1832920476 creator A5066675783 @default.
- W1832920476 creator A5074370321 @default.
- W1832920476 creator A5080237636 @default.
- W1832920476 date "2015-08-14" @default.
- W1832920476 modified "2023-10-17" @default.
- W1832920476 title "Energy Homeostasis Control in <i>Drosophila</i> Adipokinetic Hormone Mutants" @default.
- W1832920476 cites W111059579 @default.
- W1832920476 cites W1503760388 @default.
- W1832920476 cites W1547878137 @default.
- W1832920476 cites W1640770560 @default.
- W1832920476 cites W1826826024 @default.
- W1832920476 cites W1965495036 @default.
- W1832920476 cites W1970151075 @default.
- W1832920476 cites W1970431812 @default.
- W1832920476 cites W1970702783 @default.
- W1832920476 cites W1971903429 @default.
- W1832920476 cites W1972400519 @default.
- W1832920476 cites W1972446753 @default.
- W1832920476 cites W1974318258 @default.
- W1832920476 cites W1976835212 @default.
- W1832920476 cites W1978805431 @default.
- W1832920476 cites W1980382915 @default.
- W1832920476 cites W1982568610 @default.
- W1832920476 cites W1982974010 @default.
- W1832920476 cites W1983104391 @default.
- W1832920476 cites W1984517281 @default.
- W1832920476 cites W1984726207 @default.
- W1832920476 cites W1985997824 @default.
- W1832920476 cites W1986656413 @default.
- W1832920476 cites W1987081822 @default.
- W1832920476 cites W1991379544 @default.
- W1832920476 cites W1997451754 @default.
- W1832920476 cites W1997572376 @default.
- W1832920476 cites W1998356880 @default.
- W1832920476 cites W1999537430 @default.
- W1832920476 cites W2002748069 @default.
- W1832920476 cites W2004102821 @default.
- W1832920476 cites W2005883764 @default.
- W1832920476 cites W2008427653 @default.
- W1832920476 cites W2011202543 @default.
- W1832920476 cites W2012537531 @default.
- W1832920476 cites W2012966678 @default.
- W1832920476 cites W2013202024 @default.
- W1832920476 cites W2014887370 @default.
- W1832920476 cites W2016980163 @default.
- W1832920476 cites W2020168144 @default.
- W1832920476 cites W2022389622 @default.
- W1832920476 cites W2023744313 @default.
- W1832920476 cites W2024654359 @default.
- W1832920476 cites W2029684447 @default.
- W1832920476 cites W2032972160 @default.
- W1832920476 cites W2040421048 @default.
- W1832920476 cites W2046064425 @default.
- W1832920476 cites W2048092161 @default.
- W1832920476 cites W2053277517 @default.
- W1832920476 cites W2060869324 @default.
- W1832920476 cites W2062793520 @default.
- W1832920476 cites W2063124040 @default.
- W1832920476 cites W2063491689 @default.
- W1832920476 cites W2071073520 @default.
- W1832920476 cites W2071317537 @default.
- W1832920476 cites W2073787597 @default.
- W1832920476 cites W2074304856 @default.
- W1832920476 cites W2074326067 @default.
- W1832920476 cites W2074541079 @default.
- W1832920476 cites W2078695012 @default.
- W1832920476 cites W2079768926 @default.
- W1832920476 cites W2083798431 @default.
- W1832920476 cites W2085948357 @default.
- W1832920476 cites W2086631626 @default.
- W1832920476 cites W2087325597 @default.
- W1832920476 cites W2087952796 @default.
- W1832920476 cites W2088295098 @default.
- W1832920476 cites W2090634740 @default.
- W1832920476 cites W2091260866 @default.
- W1832920476 cites W2095301158 @default.
- W1832920476 cites W2099084891 @default.
- W1832920476 cites W2099536877 @default.
- W1832920476 cites W2107498496 @default.
- W1832920476 cites W2109842629 @default.
- W1832920476 cites W2113630534 @default.
- W1832920476 cites W2117004724 @default.
- W1832920476 cites W2120132994 @default.
- W1832920476 cites W2120326136 @default.
- W1832920476 cites W2127167047 @default.
- W1832920476 cites W2130095246 @default.
- W1832920476 cites W2130900826 @default.
- W1832920476 cites W2133579915 @default.
- W1832920476 cites W2143821932 @default.
- W1832920476 cites W2149200224 @default.
- W1832920476 cites W2149329727 @default.