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• W1832924810 startingPage "93" @default.
• W1832924810 abstract "Cell size, the nucleocytoplasmic ratio, and the DNA content of the nucleus are mutually interdependent. It is, therefore, justifiable to use the data on one of these features for the approximate determination of the other two. In the evolutionary process, every factor that favors a change in one of these characters influences the state of the other two. For vertebrates, the primitive DNA content was probably not very different from the actual state in Latimeria, many elasmobranchs, and some anurans. It is moderately reduced in mammals. In Dipnoi and Urodela, DNA content and cell size are greatly increased. A reduction in both these features occurred in reptiles, birds, and the majority of teleosts. Regularities occur in the cell size of passerine birds, which suggest that they are indispensable for a high metabolism. The diverse levels of cell-size variability in other vertebrates demonstrate that natural selection may be indifferent to changes in cell size unless they are fairly pronounced. Natural selection could have decreased cell size and DNA content when it favored a decrease in overall size of the organism, speed of development, high metabolism, and rejection of unused genetic information. An increase in DNA content and in cell size could be favored as a means of economizing in structural material with an enlargement of the body and a reduction in maintenance costs. It could confer a greater resistance of cells to changes in the composition of body intercellular fluids." @default.
• W1832924810 created "2016-06-24" @default.
• W1832924810 creator A5089000390 @default.
• W1832924810 date "1976-01-01" @default.
• W1832924810 modified "2023-10-14" @default.
• W1832924810 title "Cell Size and Nuclear DNA Content in Vertebrates" @default.
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• W1832924810 doi "https://doi.org/10.1016/s0074-7696(08)61648-4" @default.
• W1832924810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/770372" @default.
• W1832924810 hasPublicationYear "1976" @default.
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